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Tight junction protein 1

This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Occludin, V1a, CAN, E-cadherin, Actin
Papers using ZO-1 antibodies
The metagenomics RAST server - a public resource for the automatic phylogenetic and functional analysis of metagenomes.
Vidal-Puig Antonio J., In PLoS Biology, 2007
... Antibody against ZO-1 was from Abcam (AB96594) (Cambridge, MA) ...
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
Turner Jerrold R. et al., In The Journal of Cell Biology, 2001
... Wild-type, villin–EGFP-occludin, and villin–EGFP-occludin/villin–mRFP1–ZO-1 transgenic mice were maintained on ...
The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis.
Baker Nicholas E., In PLoS Biology, 1998
... Mouse anti-Llgl2 and rabbit anti-ZO-1 antibodies were purchased from Abnova (Taipei, Taiwan) and Zymed ...
Measurement of intracellular pH in cultured cells by flow cytometry with BCECF-AM
Rogers Suzanne et al., In BMC Evolutionary Biology, 1995
... as follows: α-c-Myc (clone 9E10) and α-hemagglutinin (HA) (Santa Cruz Biotechnology, Santa Cruz, CA, USA); α-ZO-1 (Zonula Occludens - 1) (Zymed, San Francisco, CA, USA); α-GLUT3 (Abcam, Cambridge, MA, USA); Fluorescein ...
Purification and sequence determination of guanylate kinase from pig brain
Anderson James Melvin et al., In The Journal of Cell Biology, 1992
... (Stratagene, La Jolla, CA), and a human liver library in lambda ZAP specifically primed with anti-sense ZO-1 oligonucleotides (CLONTECH ...
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Papers on ZO-1
HIF-1α regulates EMT via the Snail and β-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis.
Wang et al., Shanghai, China. In J Cell Mol Med, Feb 2016
In vivo, the protein levels of HIF-1α and α-SMA were increased at 2 hrs and the level of ZO-1 (Zonula Occluden-1) was reduced at 12 hrs.
A PDZ-Like Motif in the Biliary Transporter ABCB4 Interacts with the Scaffold Protein EBP50 and Regulates ABCB4 Cell Surface Expression.
Aït-Slimane et al., Paris, France. In Plos One, Dec 2015
The stability of several ABC transporters is regulated through their binding to PDZ (PSD95/DglA/ZO-1) domain-containing proteins.
Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells.
Tanihara et al., Tokyo, Japan. In Sci Rep, Dec 2015
Further, K-115 disrupted cellular localization of ZO-1 expression in SCE-cell monolayers.
Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.
Ganju et al., United States. In Mol Oncol, Nov 2015
Robo4 inhibits breast cancer growth and metastasis by regulating tumor angiogenesis, endothelial leakage and tight junction protein zonula occludens protein-1 (ZO-1) downregulation.
Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus.
Wolff et al., Paris, France. In Prog Biophys Mol Biol, Oct 2015
PDZ (PSD-95/Dlg/ZO-1) domains play a major role in neuronal homeostasis in which they act as scaffold domains regulating cellular trafficking, self-association and catalytic activity of essential proteins such as kinases and phosphatases.
Drug Transporters and Na+/H+ Exchange Regulatory Factor PSD-95/Drosophila Discs Large/ZO-1 Proteins.
Friedman et al., Pittsburgh, United States. In Pharmacol Rev, Jul 2015
Several clinically significant drug transporters possess a recognition sequence that binds to PSD-95/Drosophila discs large/ZO-1 (PDZ) proteins.
Effect of dexmedetomidine on rats with renal ischemia-reperfusion injury and the expression of tight junction protein in kidney.
Hou et al., Shenyang, China. In Int J Clin Exp Med, 2014
The kidneys in each group were made out pathologic slices after 6 h I/R, stained with HE; blood samples were taken with separation plasma, creatinine (Scr) and urea nitrogen (BUN) were detected by automatic biochemical analyzer; IL-1β and TNF-α were detected by Enzyme-linked Immunosorbent Assay (ELISA); the expression level of tight junction protein ZO-1 and protein occludin in kidney were detected by Western-blot.
PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins.
Banerjee et al., Stillwater, United States. In Biology (basel), 2014
PDZ (PSD-95/Discs large/ZO-1 homologous) domains are well known protein-protein interaction modules involved in various key signaling pathways.
Architecture of tight junctions and principles of molecular composition.
Anderson et al., Bethesda, United States. In Semin Cell Dev Biol, 2014
In general the architecture can be conceptualized into compartments with the transmembrane barrier proteins (claudins, occludin, JAM-A, etc.), linked to peripheral scaffolding proteins (such as ZO-1, afadin, MAGI1, etc.) which are in turned linked to actin and microtubules through numerous linkers (cingulin, myosins, protein 4.1, etc.).
RASSF6; the Putative Tumor Suppressor of the RASSF Family.
Hata et al., Tokyo, Japan. In Cancers (basel), 2014
RASSF6 additionally harbors the PSD-95/Discs large/ZO-1 (PDZ)-binding motif.
Optimization of immunostaining on flat-mounted human corneas.
He et al., Saint-Étienne, France. In Mol Vis, 2014
METHODS: The staining of four ubiquitous proteins, ZO-1, hnRNP L, actin, and histone H3, with clearly different subcellular localizations, was analyzed in ECs of organ-cultured corneas.
Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.
Wang et al., Duarte, United States. In Cancer Cell, 2014
Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1.
The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeability.
Flanagan et al., United States. In Proc Natl Acad Sci U S A, 2012
We define the interface between the ZO-1 PDZ3-SH3-U5-GuK (PSG) and occludin coiled-coil (CC) domains.
Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling.
Sugimoto et al., Tochigi, Japan. In Proc Natl Acad Sci U S A, 2012
results suggest that ARHGEF11 mediates RhoA-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with ZO-1.
Association between segments of zonula occludens proteins: live-cell FRET and mass spectrometric analysis.
Haseloff et al., Berlin, Germany. In Ann N Y Acad Sci, 2012
tight junction protein ZO-1 (zonula occludens protein 1) has recruiting/scaffolding functions in the junctional complex of epithelial and endothelial cells
Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1.
Ivarsson et al., Leuven, Belgium. In Febs Lett, 2012
study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization
The blood-testis barrier and its implications for male contraception.
Mruk et al., New York City, United States. In Pharmacol Rev, 2012
Studies have demonstrated that some unlikely partners, namely adhesion protein complexes (e.g., occludin-ZO-1, N-cadherin-β-catenin, claudin-5-ZO-1), steroids (e.g., testosterone, estradiol-17β), nonreceptor protein kinases (e.g., focal adhesion kinase, c-Src, c-Yes), polarity proteins (e.g., PAR6, Cdc42, 14-3-3), endocytic vesicle proteins (e.g., clathrin, caveolin, dynamin 2), and actin regulatory proteins (e.g., Eps8, Arp2/3 complex), are working together, apparently under the overall influence of cytokines (e.g., transforming growth factor-β3, tumor necrosis factor-α, interleukin-1α).
CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity.
Richter et al., Worcester, United States. In Nat Commun, 2011
CPEB-mediated zonal occludens-1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm.
Denholm et al., Cambridge, United Kingdom. In Nature, 2009
We find that fly (Drosophila melanogaster) orthologues of the major constituents of the slit diaphragm, including nephrin, NEPH1 (also known as KIRREL), CD2AP, ZO-1 (TJP1) and podocin, are expressed in the nephrocyte and form a complex of interacting proteins that closely mirrors the vertebrate slit diaphragm complex.
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.
Tsukita et al., Kyoto, Japan. In Cell, 2006
These findings indicate that ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized.
More papers using ZO-1 antibodies
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Seifert H. Steven, In PLoS Pathogens, 1969
... Goat anti-actin (I19) antibody and rabbit anti-ZO-1 (clone I19) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA, ...
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