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Solute carrier family 30

ZnT6, hZnT-6
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, tissue-nonspecific alkaline phosphatase, LIV-1, HAD
Papers on ZnT6
Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.
Hozumi et al., Gifu, Japan. In J Neurosci Res, Feb 2015
ZnT3 and ZnT6 protein levels were significantly diminished in the spinal cords of sporadic ALS patients compared with controls.
Zinc transporter gene expression and glycemic control in post-menopausal women with Type 2 diabetes mellitus.
Samman et al., Sydney, Australia. In J Trace Elem Med Biol, 2014
In a randomized, double-blind, placebo-controlled, 12-week trial in postmenopausal women (n=48) with Type 2 DM we investigated the effects of supplementation with zinc (40mg/d) and flaxseed oil (FSO; 2g/d) on the gene expression of zinc transporters (ZnT1, ZnT5, ZnT6, ZnT7, ZnT8, Zip1, Zip3, Zip7, and Zip10) and metallothionein (MT-1A, and MT-2A), and markers of glycemic control (glucose, insulin, glycosylated hemoglobin [HbA1c]).
Functional consequences of the over-expression of TRPC6 channels in HEK cells: impact on the homeostasis of zinc.
Bouron et al., Grenoble, France. In Metallomics, 2014
Quantitative RT-PCR experiments showed that TRPC6 over-expression does not affect the mRNA expression of Zn transporters (ZnT-1, ZnT-5, ZnT-6, ZnT-7, ZnT-9, Zip1, Zip6, Zip7, and Zip14); however it up-regulates the mRNA expression of metallothionein-I and -II.
In situ dimerization of multiple wild type and mutant zinc transporters in live cells using bimolecular fluorescence complementation.
Assaraf et al., In J Biol Chem, 2014
The validity of the BiFC assay in ZnT dimerization was further corroborated when high fluorescence was obtained upon co-transfection of ZnT5-YC and ZnT6-YN, which are known to form heterodimers.
Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver.
Matsui et al., Kyoto, Japan. In Br J Nutr, 2013
The dietary treatments did not affect the mRNA levels of other Zn transporters such as Zip1, Zip5, ZnT1, ZnT5 and ZnT6 in the liver.
Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway.
Kambe et al., Kyoto, Japan. In Plos One, 2012
We have previously shown that secretory and membrane-bound zinc enzymes are activated in the early secretory pathway (ESP) via zinc-loading by the zinc transporter 5 (ZnT5)-ZnT6 hetero-complex and ZnT7 homo-complex (zinc transport complexes).
Zinc transporter mRNA levels in Alzheimer's disease postmortem brain.
Johnston et al., Ireland. In J Alzheimers Dis, 2011
The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease.
Effects of forced running exercise on cognitive function and its relation to zinc homeostasis-related gene expression in rat hippocampus.
Cen et al., Suzhou, China. In Biol Trace Elem Res, 2011
Rats with physical exercise (EXP) showed a significant up-regulation of mRNA expression of zinc transporter-2 (ZnT-2), ZnT-4, ZnT-5, ZnT-6, and ZnT-7, metallothionein-1 (MT-1)-MT-3, divalent cation transporter-1, and Zrt-Irt-like proteins-7 in hippocampus when compared with control rats.
Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome.
Giulivi et al., Davis, United States. In Hum Mol Genet, 2011
Higher P:M, and lower ZnT6 and mature frataxin protein expression suggested defective zinc and iron metabolism arising from altered ZnT protein expression, which in turn impairs the activity of mitochondrial Zn-dependent proteases, critical for the import and processing of cytosolic precursors, such as frataxin.
Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway.
Kambe et al., Kyoto, Japan. In J Biol Chem, 2011
We have previously shown that two zinc transport complexes, ZnT5/ZnT6 heterodimers and ZnT7 homo-oligomers, are required for the activation of alkaline phosphatases, by converting them from the apo- to the holo-form.
Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.
Lovell et al., Lexington, United States. In Brain Pathol, 2010
our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms
Dietary zinc absorption: A play of Zips and ZnTs in the gut.
Zhou et al., Beijing, China. In Iubmb Life, 2010
Zinc transporters with manifested expression in enterocytes include ZnT1, ZnT2, ZnT4, ZnT5, ZnT6, ZnT7, Zip4, and Zip5.
Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway.
Kambe et al., Kyoto, Japan. In J Biol Chem, 2009
The cytosolic C-terminal tail of ZnT5 is important for its interaction with ZnT6 as a heterodimer.
Golgi apparatus localization of ZNT7 in the mouse cerebellum.
Wang et al., Shenyang, China. In Histol Histopathol, 2009
We have recently reported that four members of the zinc transporter (ZNT) family, ZNT1, ZNT3, ZNT4, and ZNT6, are abundantly expressed in the mouse cerebellum.
Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.
Wang et al., Shenyang, China. In Brain Res Bull, 2008
Data show that ZNT6 is extensively present in the Abeta-positive plaques in the cortex of human AD brains.
Expression of the ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation.
Huang et al., Davis, United States. In J Mol Histol, 2008
Among differences were a staining of ZNT2/ZNT5 in the ER-rich area of the epithelium in the anterior lobe, a staining of ZNT2 along the lateral and apical membrane, a luminal border staining of ZNT4, a staining of ZNT5 in the Golgi area of the epithelium in the ventral lobe, a uniform expression of ZNT6 across the lobes and ages, and a staining of ZNT7 in all lobes across ages.
Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.
Rink et al., Aachen, Germany. In J Leukoc Biol, 2008
hZnT-6 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells.
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