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Zinc finger protein 81

ZNF81, MRX45
This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause mental retardation X-linked type 45 (MRX45). [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: ZNF41, ZNF21, synapsin I, NET, XLMR
Papers on ZNF81
XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.
Mandel et al., Illkirch-Graffenstaden, France. In Am J Hum Genet, 2013
We particularly question the implication in XLID of ten of them (AGTR2, MAGT1, ZNF674, SRPX2, ATP6AP2, ARHGEF6, NXF5, ZCCHC12, ZNF41, and ZNF81), in which truncating variants or previously published mutations are observed at a relatively high frequency within this cohort.
335.4 kb microduplication in chromosome band Xp11.2p11.3 associated with developmental delay, growth retardation, autistic disorder and dysmorphic features.
Serra et al., Roma, Italy. In Gene, 2012
spanning 335.4 kb and including 3 known genes (ZNF81, ZNF182 and SPACA5).
Microduplication of Xp11.23p11.3 with effects on cognition, behavior, and craniofacial development.
Brown et al., Houston, United States. In Clin Genet, 2011
The duplicated region harbors three known X-linked mental retardation genes: FTSJ1, ZNF81, and SYN1.
Recurrent deletion of ZNF630 at Xp11.23 is not associated with mental retardation.
de Brouwer et al., Nijmegen, Netherlands. In Am J Med Genet A, 2010
ZNF630 is a member of the primate-specific Xp11 zinc finger gene cluster that consists of six closely related genes, of which ZNF41, ZNF81, and ZNF674 have been shown to be involved in mental retardation.
ZNF674: a new kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation.
van Bokhoven et al., Nijmegen, Netherlands. In Am J Hum Genet, 2006
ZNF674 belongs to a cluster of seven highly related zinc-finger genes in Xp11, two of which (ZNF41 and ZNF81) were implicated previously in XLMR.
[Non-specific X-linked mental retardation].
Martínez-Castellano, Valencia, Spain. In Rev Neurol, 2006
Other types of functions of the known genes include establishing and modulating synapses (DLG3, IL1RAPL, NLGN4X, GDI1), regulating transcription (ZNF41, ZNF81, PQBP1) translation (FTSJ1), and fatty acid metabolism (FACL4), etc. CONCLUSIONS: Each gene that has been identified only accounts for a minor fraction of the total amount of XLMR, and even if taken together they still do not explain half the cases of non-specific XLMR.
Psychometric assessment of families with X-linked mental retardation.
Gabreels et al., Nijmegen, Netherlands. In Am J Med Genet, 1999
In addition, these preliminary results indicated family-specific cognitive profiles in MRX45 and MRX46.
Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval.
Meindl et al., München, Germany. In Genome Res, 1996
A combined YAC-cosmid contig was constructed along the genomic map and was used for fine-mapping of 15 polymorphic microsatellites and 30 expressed sequence tags (ESTs) or sequence transcribed sites (STSs), revealing the following order: tel-(SYN-TIMP)-(DXS426-ELK1)-ZNF(CA) n-L1-DXS1367-ZNF81-ZNF21-DXS6616- (HB3-OATL1pseudogenes-DXS6950)-DXS6949-DXS694 1-DXS7464E(MG61)-GW1E(EBP)- DXS7927E(MG81)-RBM- DXS722-DXS7467E(MG21)-DXS1011E-WASP-DXS6940++ +-DXS7466E(MG44)-GF1- DXS226-DXS1126-DXS1240-HB1- DXS7469E-(DXS6665-DXS1470)-TFE3-DXS7468E-+ ++SYP-DXS1208-HB2E-DXS573-DXS1331- DXS6666-DXS1039-DXS 1426-DXS1416-DXS7647-DXS8222-DXS6850-DXS255++ +-CIC-5-DXS146-cen.
Cloning and characterization of a novel zinc finger gene in Xp11.2.
Francke et al., Stanford, United States. In Genomics, 1995
ZNF157 maps to the telomeric end of a cluster of ZNF genes that includes ZNF21, ZNF41, and ZNF81.
A high-resolution map of genes, microsatellite markers, and new dinucleotide repeats from UBE1 to the GATA locus in the region Xp11.23.
Rosen et al., Chicago, United States. In Genomics, 1995
The marker order was determined to be DXS1367-ZNF81-DXS6849-ZNF21-DXS6616-DXS 6950-DXS6949.
A 1.8-Mb YAC contig in Xp11.23: identification of CpG islands and physical mapping of CA repeats in a region of high gene density.
Davies et al., Oxford, United Kingdom. In Genomics, 1994
Knight et al., 1994, Genomics 21: 180-187), at least four more genes map within 400 kb: a cluster of Krüppel-type zinc finger genes (including ZNF21, ZNF41, and ZNF81) and ELK-1, a member of the ets oncogene superfamily.
Physical mapping in a YAC contig of 11 markers on the human X chromosome in Xp11.23.
Kwan et al., Chicago, United States. In Genomics, 1994
The region analyzed spans the distal marker UBE1 and the ARAF1/TIMP/SYN1/PFC gene cluster and further extends proximally to include ELK1, ZNF21, ZNF81, and OATL1 in a single contig.
Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1.
Coleman et al., London, United Kingdom. In Genomics, 1994
The ZNF21, ZNF41, and ZNF81 genes encode Krüppel-type zinc-finger proteins (ZFPs) and have previously been mapped to chromosome Xp.
A novel X-linked member of the human zinc finger protein gene family: isolation, mapping, and expression.
Grimaldi et al., Napoli, Italy. In Mamm Genome, 1992
We report the partial characterization of a novel putative zinc finger gene of the Krüppel-type (ZNF81), isolated from an X Chromosome (Chr) specific library.
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