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Zinc finger protein 41

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ZNF81, A-Raf, ZNF21, XLMR, ACID
Papers on ZNF41
XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.
Mandel et al., Illkirch-Graffenstaden, France. In Am J Hum Genet, 2013
We particularly question the implication in XLID of ten of them (AGTR2, MAGT1, ZNF674, SRPX2, ATP6AP2, ARHGEF6, NXF5, ZCCHC12, ZNF41, and ZNF81), in which truncating variants or previously published mutations are observed at a relatively high frequency within this cohort.
335.4 kb microduplication in chromosome band Xp11.2p11.3 associated with developmental delay, growth retardation, autistic disorder and dysmorphic features.
Serra et al., Roma, Italy. In Gene, 2012
where few pathogenic genes have been identified to date (such as ZNF41, PQB1 and ZNF81).
X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma.
Gershwin et al., Davis, United States. In Clin Exp Immunol, 2012
Identified genes include transcription factors (ARX, HSFX1, ZBED1, ZNF41) and surface antigens (IL1RAPL2, PGRMC1), and pathway analysis suggests their involvement in cell proliferation (PGK1, SMS, UTP14A, SSR4), apoptosis (MTM1), inflammation (ARAF) and oxidative stress (ENOX2).
Recurrent deletion of ZNF630 at Xp11.23 is not associated with mental retardation.
de Brouwer et al., Nijmegen, Netherlands. In Am J Med Genet A, 2010
ZNF630 is a member of the primate-specific Xp11 zinc finger gene cluster that consists of six closely related genes, of which ZNF41, ZNF81, and ZNF674 have been shown to be involved in mental retardation.
X linked mental retardation: a clinical guide.
Raymond, Cambridge, United Kingdom. In J Med Genet, 2006
Secondly, the relative prevalence of genes causing only non-syndromic mental retardation (IL1RAPL1, TM4SF2, ZNF41, FTSJ1, DLG3, FACL4, PAK3, ARHGEF6, FMR2, and GDI) is summarised.
ZNF674: a new kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation.
van Bokhoven et al., Nijmegen, Netherlands. In Am J Hum Genet, 2006
ZNF674 belongs to a cluster of seven highly related zinc-finger genes in Xp11, two of which (ZNF41 and ZNF81) were implicated previously in XLMR.
[Non-specific X-linked mental retardation].
Martínez-Castellano, Valencia, Spain. In Rev Neurol, 2006
Other types of functions of the known genes include establishing and modulating synapses (DLG3, IL1RAPL, NLGN4X, GDI1), regulating transcription (ZNF41, ZNF81, PQBP1) translation (FTSJ1), and fatty acid metabolism (FACL4), etc. CONCLUSIONS: Each gene that has been identified only accounts for a minor fraction of the total amount of XLMR, and even if taken together they still do not explain half the cases of non-specific XLMR.
Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation.
Kalscheuer et al., Berlin, Germany. In Am J Hum Genet, 2003
ZNF41 is critical for cognitive development
Polymorphic X-chromosome inactivation of the human TIMP1 gene.
Brown et al., Vancouver, Canada. In Am J Hum Genet, 1999
Since many genes that escape X inactivation are clustered, we examined the expression of four genes (ARAF1, ELK1, ZNF41, and ZNF157) within approximately 100 kb of TIMP1.
Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41.
Grimaldi et al., Napoli, Italy. In Cytogenet Cell Genet, 1998
ZNF41 belongs to a cluster of human zinc finger genes residing within a gene-rich region at Xp11.23.
Cloning and characterization of a novel zinc finger gene in Xp11.2.
Francke et al., Stanford, United States. In Genomics, 1995
ZNF157 maps to the telomeric end of a cluster of ZNF genes that includes ZNF21, ZNF41, and ZNF81.
A 1.8-Mb YAC contig in Xp11.23: identification of CpG islands and physical mapping of CA repeats in a region of high gene density.
Davies et al., Oxford, United Kingdom. In Genomics, 1994
Knight et al., 1994, Genomics 21: 180-187), at least four more genes map within 400 kb: a cluster of Krüppel-type zinc finger genes (including ZNF21, ZNF41, and ZNF81) and ELK-1, a member of the ets oncogene superfamily.
Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1.
Coleman et al., London, United Kingdom. In Genomics, 1994
The ZNF21, ZNF41, and ZNF81 genes encode Krüppel-type zinc-finger proteins (ZFPs) and have previously been mapped to chromosome Xp.
A novel X-linked member of the human zinc finger protein gene family: isolation, mapping, and expression.
Grimaldi et al., Napoli, Italy. In Mamm Genome, 1992
ZNF81 represents yet another example, together with ZFX, ZNF41, and ZNF21, of members of the zinc finger gene family residing within the short arm of the human X Chr.
Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome.
Grimaldi et al., Napoli, Italy. In Genomics, 1991
We have isolated a novel human zinc finger gene, ZNF41, from a human X-chromosome-specific library.
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