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Ring finger protein 216

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, beta2, c-Myc, ACID, Desmin
Papers on Zin
Antibacterial Studies and Effect of Poloxamer on Gold Nanoparticles by Zingiber Officinale Extracted Green Synthesis.
Antony et al., In J Nanosci Nanotechnol, Jul 2015
The Zin- giber officinale (Z.
Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-κB signaling.
Campbell et al., Philadelphia, United States. In J Immunol, 2011
By promoting polyubiquitylation and degradation, E3 ubiquitin ligase Triad3A is identified as an interaction partner for the killer cell Ig-like receptor KIR2DL4 cytoplasmic domain.
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
Hiscott et al., Montréal, Canada. In Plos Pathog, 2009
Triad3A represents a versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection.
Expression of two inflammation-related genes (RIPK3 and RNF216) in mononuclear cells is associated with weight-loss regain in obese subjects.
Martínez et al., Spain. In J Nutrigenet Nutrigenomics, 2008
Gene expression of RIPK3 and RNF216 in PBMC could identify those obese subjects, who will regain more weight after a successful initial weight loss. The mRNA levels of these genes could be nutrigenomic biomarkers for predicting obesity treatment outcome.
Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.
Chuang et al., Los Angeles, United States. In J Biol Chem, 2006
Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding and play a crucial role in innate immunity
Identification of novel oligodendroglioma-associated candidate tumor suppressor genes in 1p36 and 19q13 using microarray-based expression profiling.
Lichter et al., Heidelberg, Germany. In Int J Cancer, 2006
Microarray analysis identified 8 genes from these regions (MGC4399, SRM, ICMT, RPL18, FTL, ZIN, FLJ10781 and DBP), which all showed significantly lower expression in 1p/19q-deleted gliomas when compared to gliomas without 1p/19q losses.
Desmin modulates lung elastic recoil and airway responsiveness.
Boriek et al., Dallas, United States. In Am J Physiol Lung Cell Mol Physiol, 2006
To test this hypothesis, respiratory system complex impedance (Zin,rs) at different positive end-expiratory pressure (PEEP) levels and quasi-static pressure-volume data were obtained in desmin-null and wild-type mice at baseline and during methacholine administration.
Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif.
Li et al., Adelaide, Australia. In J Virol, 2004
ZIN binds to purified Vif in vitro and Triad 3/ZIN interacts with HIV-1 Vif in transfected human 293T cells, as demonstrated by coimmunoprecipitation
A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc.
Lippard et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2004
Zin-naphthopyr 1 (ZNP1) affords single-excitation, dual-emission ratiometric detection of intracellular Zn(2+) through Zn(2+)-controlled switching between fluorescein and naphthofluorescein tautomeric forms.
Nitric oxide signalling by selective beta(2)-adrenoceptor stimulation prevents ACh-induced inhibition of beta(2)-stimulated Ca(2+) current in cat atrial myocytes.
Lipsius et al., Maywood, United States. In J Physiol, 2002
When ISO plus the beta(1)-AR antagonist atenolol (ISO-beta(2)-AR stimulation) or 1 microM zinterol (ZIN-beta(2)-AR stimulation) increased I(Ca,L), ACh-induced inhibition of I(Ca,L) was significantly smaller, at -21 +/- 3 and -24 +/- 3 %, respectively.
A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation.
Shu et al., Beijing, China. In J Biol Chem, 2002
interacts with RIP and inhibits tnf and il1-induced NFKB activation
Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure.
Cheng et al., Winston-Salem, United States. In J Pharmacol Exp Ther, 2001
Accordingly, we compared the effect of zinterol (ZIN), a highly selective beta2-AR agonist, on I(Ca,L) in isolated left ventricular cardiomyocytes obtained from normal control and age-matched rats with HF induced by left coronary artery ligation (4 months).
[The coupling of canine ventricular myocyte beta2-adrenoceptors to L-type calcium current].
Szabó et al., Oklahoma City, United States. In Acta Pharm Hung, 1999
UNLABELLED: To establish the functional coupling of beta adrenoceptor (beta AR) subtypes of beta 1AR and beta 2AR to L-type calcium current (ICaL), we investigated the non-selective agonist isoproterenol (ISO), and the relatively selective beta 2AR agonists zinterol (ZIN) and salbutamol (SAL) on ICaL in isolated canine ventricular myocytes in the presence and absence of CGP 20712A (CGP) and atenolol (AT), selective beta 1AR antagonists, and ICI 118,551 (ICI) a selective beta 2AR antagonist.
Canine ventricular myocyte beta2-adrenoceptors are not functionally coupled to L-type calcium current.
Szabo et al., Oklahoma City, United States. In J Cardiovasc Electrophysiol, 1999
INTRODUCTION: To establish the functional coupling of beta adrenoceptor (betaAR) subtypes beta1AR and beta2AR to L-type calcium current (I(CaL)), we investigated the nonselective agonist isoproterenol (ISO) and the relatively selective beta2AR agonists zinterol (ZIN) and salbutamol (SAL) on I(CaL) in isolated canine ventricular myocytes in the presence and absence of CGP 20712A (CGP) and atenolol (AT), selective beta1AR antagonists, and ICI 118,551 (ICI) a selective beta2AR antagonist.
Detection of mouse skeletal muscle-specific product, which includes ZF5 zinc fingers and a VP16 acidic domain, by reverse transcriptase PCR.
Niwa et al., Hiroshima, Japan. In Biochem Biophys Res Commun, 1997
ZF5, which we have cloned as a repressor on the mouse c-myc promoter, is a zinc finger protein containing Kruppel-type zinc finger and ZiN/POZ domains.
The ZiN/POZ domain of ZF5 is required for both transcriptional activation and repression.
Calame et al., New York City, United States. In Nucleic Acids Res, 1997
It contains five C-terminal zinc fingers and a conserved N-terminal ZiN/POZ domain.
Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins.
Lania et al., Napoli, Italy. In Nucleic Acids Res, 1994
Such elements include the FAX domain found in a large number of Xenopus ZFPs, the evolutionarily conserved KRAB (Krüppel-associated box) and the ZiN (zinc finger N-terminal) domains.
Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins.
Calame et al., Hiroshima, Japan. In Nucleic Acids Res, 1993
This region defines a new motif within zinc finger proteins which we have named the Zinc finger N-terminal (ZiN) domain.
Isolation of Noninhibitory Strains of Zymomonas mobilis.
Khachatourians et al., Saskatoon, Canada. In Appl Environ Microbiol, 1985
We report the first isolation of noninhibitory strains, called Zymomonas inhibition negative (Zin), after treatment with N-methyl-N'-nitro-N-nitrosoguanidine.
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