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Zic family member 2

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Shh, Six3, TGIF, HAD, CAN
Papers on ZIC2
Regulation of nucleus accumbens transcript levels in mice by early-life social stress and cocaine.
Carola et al., Roma, Italy. In Neuropharmacology, Jan 2016
We characterized 4 candidates with regard to their significant neurobiological relevance (ZIC1, ZIC2, FABP7, and PRDM12) and measured their expression in the NAC by immunohistochemistry.
Altered expression of mRNA profiles in blood of early-onset schizophrenia.
Zhang et al., Taiyuan, China. In Sci Rep, Dec 2015
The expression levels of several hub genes, including AKT1, BRCA1, CCDC134, UBD, and ZIC2 were validated using real-time quantitative PCR.
ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells.
Fan et al., In J Clin Invest, Nov 2015
Here, we analyzed transcriptome gene expression profiles of liver CSCs and non-CSCs from hepatocellular carcinoma (HCC) cells lines and found that the transcription factor (TF) ZIC2 is highly expressed in liver CSCs.
Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2.
Kasai et al., Japan. In Oncotarget, Oct 2015
Here, we found that ZIC2 is indispensable in the regulation of PDAC cell apoptosis.
Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain.
Herrera et al., San Juan de Alicante, Spain. In J Neurosci, Sep 2015
UNLABELLED: Human mutations in ZIC2 have been identified in patients with holoprosencephaly and schizophrenia.
Holoprosencephaly with cerebellar vermis hypoplasia in 13q deletion syndrome: Critical region for cerebellar dysgenesis within 13q32.2q34.
Mizuguchi et al., Tokyo, Japan. In Brain Dev, Aug 2015
Mutations in ZIC2, located within region 13q32, cause holoprosencephaly, whereas the 13q32.2q32.3
Evaluation of 12 myopia-associated genes in Chinese patients with high myopia.
Zhang et al., Guangzhou, China. In Invest Ophthalmol Vis Sci, Feb 2015
PURPOSE: Two recent large-scale genome-wide association studies identified significant associations between myopia and single nucleotide polymorphisms (SNPs) near the PRSS56, BMP3, KCNQ5, LAMA2, TOX, TJP2, RDH5, ZIC2, RASGRF1, GJD2, RBFOX1, and SHISA6 genes.
Molecular Biology of Pediatric Hydrocephalus and Hydrocephalus-related Diseases.
Kanemura et al., Takatsuki, Japan. In Neurol Med Chir (tokyo), 2014
Sixteen causative genes for HPE have been identified, of which mutations are most often found in SHH, ZIC2, SIX3, and TGIF.
Rare nasal cleft in a patient with holoprosencephaly due to a mutation in the ZIC2 gene.
Orioli et al., Rio de Janeiro, Brazil. In Birth Defects Res A Clin Mol Teratol, 2014
Patients with mutation in the ZIC2 gene usually present a normal or mildly dysmorphic face associated with a severe brain malformation.
Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells.
Ngan et al., Hong Kong, Hong Kong. In J Pathol, 2011
Our findings suggest that Zic2 is a positive modulator increasing Gli1 transcriptional and oncogenic activity by retaining Gli1 in the nucleus of cervical cancer cells.
New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases.
Odent et al., Rennes, France. In J Med Genet, 2011
Brain malformations, including neuronal migration defects, predominated in individuals with ZIC2 mutations.
Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling.
Tejpar et al., Leuven, Belgium. In J Biol Chem, 2011
role for ZIC2 as a transcriptional regulator of the beta-catenin.TCF4 complex.
Recurrent partial rhombencephalosynapsis and holoprosencephaly in siblings with a mutation of ZIC2.
Clark et al., Houston, United States. In Am J Med Genet A, 2011
mutation of ZIC2 is a rare cause of, or contributor to, RES associated with HPE.
Etiopathogenetic advances and management of holoprosencephaly: from bench to bedside.
Bona et al., Novara, Italy. In Panminerva Med, 2010
Genetic causes are responsible for about 20% of cases: they are chromosomal abnormalities and gene mutations: up to date, nine genes (SHH, ZIC2, SIX3, TGIF, PATCHED1, TDGF1/CRIPTO, FAST1, GLI2 and DHCR) are definitely associated with HPE, but many others candidate gene are under investigation.
Genetic counseling and "molecular" prenatal diagnosis of holoprosencephaly (HPE).
Odent et al., Rennes, France. In Am J Med Genet C Semin Med Genet, 2010
Since mutations in the four major genes (SHH, ZIC2, SIX3, and TGIF) have been identified in HPE patients, molecular study is performed routinely in nonsyndromic HPE.
Current recommendations for the molecular evaluation of newly diagnosed holoprosencephaly patients.
Muenke et al., Bethesda, United States. In Am J Med Genet C Semin Med Genet, 2010
This usually includes analysis of chromosomes by high-resolution karyotyping, clinical assessment to rule-out well recognized syndromes that are associated with HPE (e.g., Pallister-Hall syndrome, Smith-Lemli-Opitz syndrome and others), and molecular studies of the most common HPE associated genes (e.g., SHH, ZIC2 and SIX3).
Holoprosencephaly: an antenatally-diagnosed case series and subject review.
Tien et al., Singapore, Singapore. In Ann Acad Med Singapore, 2008
At least 7 genes have been positively implicated, including SHH, ZIC2, SIX3, TGIF, PTCH1, GLI2, and TDGF1.
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.
Elledge et al., Philadelphia, United States. In Nat Genet, 2000
6); ZIC2 at 13q32 (ref.
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
Muenke et al., New York City, United States. In Nat Genet, 1998
We now report that human ZIC2 maps to this critical deletion region and that heterozygous mutations in ZIC2 are associated with HPE.
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