gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Zinc fingers and homeoboxes 1

ZHX1, zinc-fingers and homeoboxes 1
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: ACID, V1a, ZHX3, HDAC2, Interleukin-2
Papers on ZHX1
ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis.
Li et al., Shanghai, China. In J Cancer, Dec 2015
Zinc-fingers and homeoboxes 1 (ZHX1) was implicated in the carcinogenesis of human cancers.
Prenatal diagnosis and array comparative genomic hybridization characterization of interstitial deletions of 8q23.3-q24.11 and 8q24.13 associated with Langer-Giedion syndrome, Cornelia de Lange syndrome and haploinsufficiency of TRPS1, RAD21 and EXT1.
Wang et al., Taipei, Taiwan. In Taiwan J Obstet Gynecol, Oct 2015
encompassing six OMIM genes, TRPS1, EIF3H, RAD21, SLC30A8, MED30, and EXT1, and a 1.383-Mb deletion of 8q24.13 encompassing four OMIM genes, ZHX2, DERL1, ZHX1, and ATAD2.
Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma.
MacLeod et al., Braunschweig, Germany. In Plos One, 2014
Downstream analyses of OTX2 demonstrated transcriptional activation of genes encoding transcription factors MSX1, FOXC1 and ZHX1.
Solution NMR structures of homeodomains from human proteins ALX4, ZHX1, and CASP8AP2 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
Szyperski et al., Buffalo, United States. In J Struct Funct Genomics, 2014
High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved.
MiR-199a-3p promotes gastric cancer progression by targeting ZHX1.
Li et al., Shanghai, China. In Febs Lett, 2014
Furthermore, the transcriptional regulator zinc fingers and homeoboxes 1 (ZHX1) was identified as one of the direct downstream targets of miR-199a-3p, miR-199a-3p bound to the ZHX1 3′ untranslated region (3′UTR) to regulate ZHX1 protein expression.
Construction of a recombinant eukaryotic human ZHX1 gene expression plasmid and the role of ZHX1 in hepatocellular carcinoma.
Liu et al., Jinan, China. In Mol Med Report, 2013
The zinc-fingers and homeoboxes protein 1 (ZHX1) consists of 873 amino acid residues, is localized in the cell nucleus and appears to act as a transcriptional repressor.
The SUMOylation of zinc-fingers and homeoboxes 1 (ZHX1) by Ubc9 regulates its stability and transcriptional repression activity.
Guo et al., Wuhan, China. In J Cell Biochem, 2013
Zinc-fingers and homeoboxes protein 1 (ZHX1) belongs to the ZF (zinc-fingers) class of homeodomain transcription factors, and its function remains largely unknown.
Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains.
Stammers et al., Oxford, United Kingdom. In Bmc Struct Biol, 2009
BACKGROUND: Zhx1 to 3 (zinc-fingers and homeoboxes) form a set of paralogous genes encoding multi-domain proteins.
The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension.
Folkers et al., Utrecht, Netherlands. In Biochemistry, 2009
structure of the tandem zinc-finger region of human ZHX1
Early changes in gene expression that influence the course of primary glomerular disease.
Chugh et al., Chicago, United States. In Kidney Int, 2007
Upregulation of B7.1 with the downregulation of GLEPP1, Wilms' tumor gene (WT1), megalin, and vascular endothelial growth factor started early and persisted through the course of primary glomerular disease.
Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2007
ZHX1 enhanced the transcriptional repression mediated by DNMT3B when DNMT3B is directly targeted to DNA. These results showed for the first the direct linkage between DNMT and zinc-fingers homeoboxes protein, leading to enhanced gene silencing by DNMT3B
ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.
Chugh et al., Chicago, United States. In J Biol Chem, 2007
ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease
BS69, a corepressor interacting with ZHX1, is a bifunctional transcription factor.
Miyamoto et al., Fukui, Japan. In Front Biosci, 2006
Corepressor BS69 interacts with ZHX1, a member of the ZHX family having zinc-fingers and homeoboxes.
A mechanism of induction of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene expression by interleukin-2.
Miyamoto et al., Fukui, Japan. In Biochem Biophys Res Commun, 2004
The effect of IL-2 on the expression of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene was investigated in a mouse cytotoxic T cell line, CTLL-2 cells.
The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3.
Miyamoto et al., Fukui, Japan. In Gene, 2004
These proteins not only form homodimers but heterodimers with ZHX1 as well and act as ubiquitous transcriptional repressors.
Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.
Miyamoto et al., Fukui, Japan. In Biochem J, 2003
a search of ZHX1-interacting proteins using a yeast two-hybrid system
share on facebooktweetadd +1mail to friends