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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Zinc finger E-box binding homeobox 1

ZEB1, deltaEF1, ZEB, TCF8
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: E-cadherin, miR, SNAIL, SIP1, CAN
Papers using ZEB1 antibodies
Biomarkers for epithelial-mesenchymal transitions
Krupitza G et al., In British Journal of Cancer, 2008
... -tubulin (DM1A) antibody, and rabbit polyclonal anti-ZEB1 (H-102) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
Fuxe Jonas, In PLoS ONE, 2004
... Epithelial-mesenchymal transition antibody sampler kit (#9782, including E-cadherin, Snail, Slug & ZEB1 antibodies) was procured from Cell Signaling Technology (Beverly, MA) ...
Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression.
Yang Chengfeng et al., In Environmental Health Perspectives, 1996
... -terminal kinase) (Cell Signaling Technology, Beverly, MA, USA); anti-ZEB1 (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, ...
Papers on ZEB1
Proteomic analysis of epithelial to mesenchymal transition reveals crosstalk between SNAIL and HDAC1 in breast cancer cells.
Faca et al., São Paulo, Brazil. In Mol Cell Proteomics, Feb 2016
Overexpression of transcription factors such as SNAIL, SLUG, ZEB1/2, and TWIST1, also induce EMT and are correlated to cancer aggressiveness.
miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells.
Gemma et al., Tokyo, Japan. In Int J Oncol, Feb 2016
E-cadherin expression was lower, and vimentin and ZEB1 expression were higher in 5 nintedanib-resistant cell lines.
Autosomal-Dominant Corneal Endothelial Dystrophies CHED1 and PPCD1 Are Allelic Disorders Caused by Non-coding Mutations in the Promoter of OVOL2.
Hardcastle et al., London, United Kingdom. In Am J Hum Genet, Feb 2016
OVOL2 encodes ovo-like zinc finger 2, a C2H2 zinc-finger transcription factor that regulates mesenchymal-to-epithelial transition and acts as a direct transcriptional repressor of the established PPCD-associated gene ZEB1.
High nuclear expression of Twist1 in the skeletal extramedullary disease of myeloma patients predicts inferior survival.
Zhang et al., Shijiazhuang, China. In Pathol Res Pract, Jan 2016
UNASSIGNED: The aim of the study was to investigate the expression of epithelial to mesenchymal transition (EMT)-inducing transcription factors, including Twist1 and ZEB1, in skeletal extramedullary disease (EMD) of multiple myeloma (MM) patients and to clarify the effects on clinical outcomes.
Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.
Duvic et al., Houston, United States. In Nat Genet, Dec 2015
Frequent somatic alterations were identified in TP53, CARD11, CCR4, PLCG1, CDKN2A, ARID1A, RPS6KA1 and ZEB1.
MicroRNA Regulation of Epithelial to Mesenchymal Transition.
Allgayer et al., Mannheim, Germany. In J Clin Med, Dec 2015
Here, we emphasize their interaction with core transcription factors like the zinc finger enhancer (E)-box binding homeobox (ZEB), Snail and Twist families as well as some pluripotency transcription factors.
ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
Haura et al., Kitakyūshū, Japan. In Plos One, Dec 2015
At the mRNA level, ZEB1 (TCF8), a known regulator of EMT, was >20-fold higher in HCC4006ER cells than in HCC4006 cells, and increased ZEB1 protein level was also detected.
Regulation of Epithelial-Mesenchymal Transition by E3 Ubiquitin Ligases and Deubiquitinase in Cancer.
Hayashi et al., Nagoya, Japan. In Curr Cancer Drug Targets, Dec 2015
One of the hallmarks of EMT is the diminished expression of E-cadherin and gain of mesenchymal traits, which are regulated by core EMT-inducing transcriptional factors (EMT-TFs), such as Snail/Slug, ZEB1/ZEB2, and Twist1.
F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check.
de Herreros et al., Barcelona, Spain. In Semin Cancer Biol, Dec 2015
Specific EMT transcription factors (EMT-TFs), such as Snail, Slug, Twist and Zeb, control EMT induction both during development and in cancer.
Zeb2: A multifunctional regulator of nervous system development.
O'Keeffe et al., Cork, Ireland. In Prog Neurobiol, Sep 2015
Zinc finger E-box binding homeobox (Zeb) 2 is a transcription factor, identified due its ability to bind Smad proteins, and consists of multiple functional domains which interact with a variety of transcriptional co-effectors.
Fuchs Corneal Dystrophy.
Gottsch et al., Baltimore, United States. In Prog Mol Biol Transl Sci, 2014
Multiple chromosomal loci and, more recently, causal genetic mutations have been identified for this complex disorder, including in TCF8, SLC4A11, LOXHD1, and AGBL1.
ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.
Lu et al., Shanghai, China. In Nat Cell Biol, 2014
ASPP2 prevents β-catenin from transactivating ZEB1, directly by forming an ASPP2-β-catenin-E-cadherin ternary complex and indirectly by inhibiting β-catenin's N-terminal phosphorylation to stabilize the β-catenin-E-cadherin complex.
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.
Ma et al., Houston, United States. In Nat Cell Biol, 2014
Here we identify an EMT-inducing transcription factor, zinc finger E-box binding homeobox 1 (ZEB1), as a regulator of radiosensitivity and DNA damage response.
A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma.
Sun et al., Shanghai, China. In Cancer Cell, 2014
lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion.
Molecular mechanisms of epithelial-mesenchymal transition.
Derynck et al., San Francisco, United States. In Nat Rev Mol Cell Biol, 2014
This switch in cell differentiation and behaviour is mediated by key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix-loop-helix transcription factors, the functions of which are finely regulated at the transcriptional, translational and post-translational levels.
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
Kurie et al., Houston, United States. In J Clin Invest, 2012
ZEB1 controls the expression of numerous oncogenic and tumor-suppressive miRs, including miR-34a
Lentivirus-delivered ZEB-1 small interfering RNA inhibits lung adenocarcinoma cell growth in vitro and in vivo.
Zhang et al., Xi'an, China. In J Cancer Res Clin Oncol, 2012
Data suggest that knockdown of ZEB-1 expression by lentivirus-delivered siRNA may provide a novel therapeutic target for the treatment of lung cancer.
miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5.
Chegini et al., Gainesville, United States. In Endocr Relat Cancer, 2012
Altered expression of miR-200c may have a significant impact on the outcome of leiomyomas growth, maintenance of their mesenchymal and fibrotic characteristics, and possibly their associated symptoms.
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
Beutler et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2012
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
Overexpression of ZEB1 associated with metastasis and invasion in patients with gastric carcinoma.
Li et al., Beijing, China. In Mol Cell Biochem, 2012
overexpression of ZEB1 may be related to the occurrence and development as well as invasion and metastasis of gastric adenocarcinoma.
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