MicroRNA Regulation of Epithelial to Mesenchymal Transition.
Mannheim, Germany. In J Clin Med, Dec 2015
Here, we emphasize their interaction with core transcription factors like the zinc finger enhancer (E)-box binding homeobox (ZEB), Snail and Twist families as well as some pluripotency transcription factors.
Zeb2: A multifunctional regulator of nervous system development.
Cork, Ireland. In Prog Neurobiol, Sep 2015
Zinc finger E-box binding homeobox (Zeb) 2 is a transcription factor, identified due its ability to bind Smad proteins, and consists of multiple functional domains which interact with a variety of transcriptional co-effectors.
Fuchs Corneal Dystrophy.
Baltimore, United States. In Prog Mol Biol Transl Sci, 2014
Multiple chromosomal loci and, more recently, causal genetic mutations have been identified for this complex disorder, including in TCF8, SLC4A11, LOXHD1, and AGBL1.
Molecular mechanisms of epithelial-mesenchymal transition.
San Francisco, United States. In Nat Rev Mol Cell Biol, 2014
This switch in cell differentiation and behaviour is mediated by key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix-loop-helix transcription factors, the functions of which are finely regulated at the transcriptional, translational and post-translational levels.