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Zinc finger CCCH-type containing 14

ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007 [PubMed 17630287]).[supplied by OMIM, Mar 2010] (from NCBI)
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Top mentioned proteins: NAB2, CAN, FATE, ACID, SC35
Papers on ZC3H14
The Drosophila ortholog of the Zc3h14 RNA binding protein acts within neurons to pattern axon projection in the developing brain.
Moberg et al., Philadelphia, United States. In Dev Neurobiol, Jan 2016
The dNab2 polyadenosine RNA binding protein is the D. melanogaster ortholog of the vertebrate ZC3H14 protein, which is lost in a form of inherited intellectual disability (ID).
Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions.
Corbett et al., Atlanta, United States. In Wiley Interdiscip Rev Rna, 2014
Here we describe both conventional and recently emerged functions for PABPN1 and PABPC and then introduce and discuss three new Pab family members, ZC3H14, hnRNP-Q1, and LARP4.
A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length.
Corbett et al., In Rna, 2014
The ZC3H14 gene, which encodes a ubiquitously expressed, evolutionarily conserved, nuclear, zinc finger polyadenosine RNA-binding protein, was recently linked to autosomal recessive, nonsyndromic intellectual disability.
Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.
Bachand et al., Sherbrooke, Canada. In Mol Cell Biol, 2013
By characterizing the ortholog of the Nab2/ZC3H14 zinc finger PABP in Schizosaccharomyces pombe, we show here that the two major fission yeast nuclear PABPs, Pab2 and Nab2, have opposing roles in posttranscriptional gene regulation.
The long and the short of it: the role of the zinc finger polyadenosine RNA binding protein, Nab2, in control of poly(A) tail length.
Fasken et al., Atlanta, United States. In Biochim Biophys Acta, 2012
A recent addition to the Pab family is the CCCH-type zinc finger class of Pabs that includes S. cerevisiae Nab2 and its human counterpart, ZC3H14.
New kid on the ID block: neural functions of the Nab2/ZC3H14 class of Cys₃His tandem zinc-finger polyadenosine RNA binding proteins.
Moberg et al., Atlanta, United States. In Rna Biol, 2012
Our recent work defined this connection to ID, as we showed that mutations in the gene encoding the ubiquitously expressed Cys3His tandem zinc-finger (ZnF) Pab, ZC3H14 (Zinc finger protein, CCCH-type, number 14) are associated with non-syndromic autosomal recessive intellectual disability (NS-ARID).
Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.
Kuss et al., Atlanta, United States. In Proc Natl Acad Sci U S A, 2011
report a intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein
MSUT2 is a determinant of susceptibility to tau neurotoxicity.
Kraemer et al., Seattle, United States. In Hum Mol Genet, 2011
MSUT2 levels may influence neuronal vulnerability to tau toxicity and aggregation.
The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?
Kraemer et al., Seattle, United States. In Biochem Soc Trans, 2010
New neuroprotective strategies targeting MSUT-2 that may be effective in modulating tau neurotoxicity in human tauopathy disorders.
Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein.
Corbett et al., Atlanta, United States. In Gene, 2009
multiple transcripts encoding several ZC3H14 isoforms exist in vivo
Recognition of polyadenosine RNA by zinc finger proteins.
Berland et al., Atlanta, United States. In Proc Natl Acad Sci U S A, 2007
these proteins are members of an evolutionarily conserved family of poly(A) RNA binding proteins
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