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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Zinc finger protein 350

ZBRK1, ZNF350, zinc finger protein 350
Top mentioned proteins: Iris, GADD45, TIF1beta, CAN, V1a
Papers on ZBRK1
By moonlighting in the nucleus villin regulates epithelial plasticity.
Khurana et al., Houston, United States. In Mol Biol Cell, Jan 2016
Additionally, we determined that villin directly interacts with a transcriptional corepressor and ligand of the Slug promoter, ZBRK1.
ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer.
Ye et al., Wuhan, China. In Oncotarget, Apr 2015
In the present study, we identified ZBRK1 as a novel VHL interacting protein by yeast two-hybrid screening, and found a single ZBRK1-binding site located in the VHL promoter region.
Tetrameric ZBRK1 DNA binding domain has affinity towards cognate DNA in absence of zinc ions.
Varma et al., Mumbai, India. In Biochem Biophys Res Commun, 2014
Human ZBRK1 is a zinc-finger transcription repressor protein, which recognizes double helical DNA containing consensus sequences of 5'GGGXXXCAGXXXTTT3'.
Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1.
White et al., Montréal, Canada. In Nucleic Acids Res, 2014
The two form a complex with C2H2 zinc-finger transcription factor ZBRK1 on an intronic binding site in the growth arrest and DNA-damage-inducible α (GADD45A) gene and a novel site in the fibroblast growth factor 2 (FGF2) gene.
High-density array analysis of DNA methylation in Tamoxifen-resistant breast cancer cell lines.
Arcaro et al., Amherst Center, United States. In Epigenetics, 2014
ZNF350 and MAGED1, two genes hypermethylated in both cell lines, were examined in greater detail.
Analysis of ZNF350/ZBRK1 promoter variants and breast cancer susceptibility in non-BRCA1/2 French Canadian breast cancer families.
INHERIT BRCAs et al., Québec, Canada. In J Hum Genet, 2013
ZNF350/ZBRK1 is a transcription factor, which associates with BRCA1 to co-repress GADD45A to regulate DNA damage repair, and the expression of ZNF350 is altered in different human carcinomas.
Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancer.
Wang et al., Tainan City, Taiwan. In Plos One, 2012
ZBRK1, a zinc finger protein that interacts with breast cancer 1 (BRCA1) and KRAB-ZFP-associated protein 1 (KAP1), has been suggested to serve as a tumor suppressor via repression of tumor metastasis/invasion.
ZBRK1 represses HIV-1 LTR-mediated transcription.
Takaku et al., Narashino, Japan. In Febs Lett, 2012
We show that ZBRK1 negatively regulates the HIV-1 LTR.
Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality.
Chen et al., Taipei, Taiwan. In Plos One, 2011
The E2F1 regulated activities of the cyclin D1 and ZBRK1 promoters were suppressed by BGLF4 in a dose dependent manner.
The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2.
Krobitsch et al., Berlin, Germany. In Hum Mol Genet, 2011
KRAB-containing zinc-finger transcriptional regulator, ZBRK1, an interaction partner of the SCA2 gene product ataxin-2.
Novel stromal biomarkers in human breast cancer tissues provide evidence for the more malignant phenotype of estrogen receptor-negative tumors.
Sang et al., Tallahassee, United States. In J Biomed Biotechnol, 2010
Two putative biomarkers, T-cell receptor alpha (TCR-α) and zinc finger and BRCA1-interacting protein with a KRAB domain (ZBRK1), were detected in leukocytes of ER-positive and endothelial cells of ER-negative tissues, respectively.
A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing.
Trono et al., Lausanne, Switzerland. In Bmc Genomics, 2010
high levels of gene activity in the genomic environment and the pre-deposition of repressive histone marks within a gene increase its susceptibility to KRAB/KAP1-mediated repression
C-terminal binding protein and poly(ADP)ribose polymerase 1 contribute to repression of the p21(waf1/cip1) promoter.
Lundblad et al., Portland, United States. In Oncogene, 2010
We localized CtBP-responsive repression elements to the proximal promoter region, and found ZBRK1 overexpression could also overcome DNA damage-dependent, but not p53-dependent activation through this region.
RB·E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1.
Wang et al., Tainan City, Taiwan. In J Biol Chem, 2010
RB.E2F1 complex plays a critical role in ZBRK1 transcriptional repression, and loss of this repression may contribute to cellular sensitivity of DNA damage, ultimately leading to carcinogenesis.
Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.
Papa et al., Israel. In Mol Carcinog, 2010
We genotyped Jewish-Ashkenazi women for functional single-nucleotide polymorphisms (SNPs) in the AKT1 (C>T rs3730358) and the PERP (C>T rs2484067) genes that affect p53-mediated apoptosis, as well as two tag-SNPs in the CHEK2 (C>T rs743184) and the ZBRK1/ZNF350 (G>A rs2278414) genes that encode for proteins involved in growth arrest following DNA damage.
KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading.
Trono et al., Lausanne, Switzerland. In Plos Genet, 2010
KRAB/KAP1 recruitment induces long-range repression through the spread of heterochromatin.
Derepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis.
Lee et al., Irvine, United States. In J Biol Chem, 2010
Data found that HMGA2, along with a dozen of other genes, was co-repressed by ZBRK1, BRCA1, and CtIP.
Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature.
Lee et al., Irvine, United States. In Cancer Cell, 2006
BRCA1 exerts transcriptional repression through interaction with CtIP in the C-terminal BRCT domain and ZBRK1 in the central domain.
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