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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD38, CAN, HAD, Lck, CD4
Papers using ZAP-70 antibodies
Protein-protein interaction inhibitors get into the groove
Kanellopoulos Jean, In PLoS ONE, 2011
... Anti ZAP70: 1E7 (probe reagent, BD Biosciences or eBioscience); ...
Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin
Bretscher Anthony et al., In The Journal of Cell Biology, 1997
... Rabbit anti–human ERM and mouse anti–human ZAP-70 were obtained from Cell Signaling Technology ...
A novel receptor-mediated nuclear protein import pathway
Samelson Lawrence E. et al., In The Journal of Experimental Medicine, 1995
... Rabbit sera are anti–ZAP-70 (8), anti-GFP (Clontech ...
Papers on ZAP-70
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
Puck et al., Hyderābād, India. In J Exp Med, Feb 2016
Whole-exome sequencing performed on five family members revealed the affected siblings to be compound heterozygous for two unique missense mutations in the 70-kD T cell receptor ζ-chain associated protein (ZAP-70).
Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL.
Boom et al., Cleveland, United States. In J Immunol, Feb 2016
Mycobacterium tuberculosis cell wall glycolipid, lipoarabinomannan, can inhibit CD4(+) T cell activation by downregulating the phosphorylation of key proximal TCR signaling molecules: Lck, CD3ζ, ZAP70, and LAT.
Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis.
Rafei et al., Montréal, Canada. In Aging Cell, Feb 2016
As a result, stimulation of T cells derived from rIL-21-treated aged mice displayed enhanced activation of Lck, ZAP-70, and ERK, which ultimately boosted their IL-2 production, CD25 expression, and proliferation capabilities in comparison with T cells derived from control aged mice.
Prognostic Factors for Chronic Lymphocytic Leukemia.
Puvvada et al., Tucson, United States. In Curr Hematol Malig Rep, Feb 2016
The prognostic information can be categorized into three categories: genetic abnormalities which include 17p, 11q, and immunoglobulin heavy chain variable (IGHV) abnormalities; biochemical abnormalities and cell surface markers which include serum thymidine kinase, β-2-microglobulin, CD49d, CD38, and ZAP-70 levels; and patient characteristics which include sex, age, and performance status.
Expression and regulation of COP1 in chronic lymphocytic leukemia cells for promotion of cell proliferation and tumorigenicity.
Xu et al., Xuzhou, China. In Oncol Rep, Jan 2016
The observed upregulated expression of COP1 in CLL patients was positively correlated with CLL clinical stage and ZAP-70 expression, but not del(13q14) and del(17q-).
Predicting Prognosis in Chronic Lymphocytic Leukemia in the Contemporary Era.
Wang et al., Chicago, United States. In Jama Oncol, Oct 2015
CD38 and ZAP-70 status of malignant cells and unmutated immunoglobulin variable heavy chain gene have similarly been validated to predict adverse prognosis, but their implications on treatment selection have not been proven.
Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach.
Ancuta et al., Montréal, Canada. In Retrovirology, 2014
Transcripts significantly enriched in Th17 versus Th1 were previously associated with the regulation of TCR signaling (ZAP-70, Lck, and CD96) and Th17 polarization (RORγt, ARNTL, PTPN13, and RUNX1).
The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration.
Isakov et al., Beersheba, Israel. In Front Immunol, 2014
They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules, such as Cbl, ZAP-70, CasL, and STAT5.
Modulation of CD44 Activity by A6-Peptide.
Finlayson, United States. In Front Immunol, 2014
Recently, A6 has been shown to be directly cytotoxic for B-lymphocytes obtained from patients with chronic lymphocytic leukemia expressing the kinase, ZAP-70.
CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.
Gattei et al., Novara, Italy. In J Clin Oncol, 2014
The importance of CD49d over other flow cytometry-based prognosticators (eg, CD38, ZAP-70) was ranked by recursive partitioning.
Commonalities and differences between Brassica and Arabidopsis self-incompatibility.
Nishio et al., Sendai, Japan. In Hortic Res, 2013
In Brassicaceae, the self-incompatibility response is mediated by allele-specific interaction of the stigma-localized S-locus receptor kinase (SRK) with the pollen coat-localized ligand (SCR/SP11).
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity.
Goronzy et al., Stanford, United States. In Nat Med, 2012
We identified an age-associated defect in T cell receptor (TCR)-induced extracellular signal-regulated kinase (ERK) phosphorylation in naive CD4(+) T cells, whereas other signals, such as ζ chain-associated protein kinase 70 (ZAP70) and phospholipase C-γ1 phosphorylation, were not impaired.
Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia.
Byrd et al., Heidelberg, Germany. In J Clin Oncol, 2012
Comprehensive quantitative DNA methylation analysis of the ZAP-70 gene in CLL identified important regions responsible for transcriptional regulation.
Quantification of ZAP-70 mRNA by real-time PCR is a prognostic factor in chronic lymphocytic leukemia.
Xu et al., Nanjing, China. In J Cancer Res Clin Oncol, 2012
The expression of ZAP-70 mRNA was significantly associated with Binet stage.
Fine-tuning of proximal TCR signaling by ZAP-70 tyrosine residues in Jurkat cells.
Boldizsar et al., Pécs, Hungary. In Int Immunol, 2012
These data indicate that previously not characterized Y069, Y126 and Y178 in ZAP-70 participate in the fine regulation of TCR signaling.
Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.
Samelson et al., Bethesda, United States. In Immunity, 2011
The kinase ZAP-70 distributed completely with the TCRζ chain and both partially mixed with the adaptor LAT in activated cells, thus showing localized activation of LAT by TCR-coupled ZAP-70.
Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia.
Keating et al., Houston, United States. In J Clin Oncol, 2011
PATIENTS AND METHODS: Traditional laboratory, clinical prognostic, and newer prognostic factors such as fluorescent in situ hybridization (FISH), IGHV mutation status, and ZAP-70 expression evaluated at first patient visit to MD Anderson Cancer Center were correlated by multivariable analysis with time to first treatment.
[Prognostic significance of new biological markers in chronic lymphocytic leukaemia].
Gotić et al., In Srp Arh Celok Lek, 2011
expression of CD38 antigen and ZAP-70 have an exceptional significance in the prediction of prognosis in CLL patients.
The Shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation.
Baldari et al., Milano, Italy. In Plos One, 2010
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 to the phosphorylated subunit of the TCR/CD3 complex.
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