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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Alpha-2-glycoprotein 1, zinc-binding

ZAG, zinc-alpha2-glycoprotein, Zn-alpha2-glycoprotein, AZGP1
has similarity to class I major histocompatibility complex (MHC) antigens [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CD45, fibrillin-1, ACID, CAN, HAD
Papers using ZAG antibodies
Purification and characterization of a tumor lipid-mobilizing factor
Tisdale M J et al., In British Journal of Cancer, 1997
... purchased from Calbiochem through CN Biosciences UK (Nottingham, UK), while mouse monoclonal antibody to human ZAG was from Santa Cruz Biotechnology through Autogen Bio Clear ...
Papers on ZAG
Reduced AZGP1 expression is an independent predictor of early PSA recurrence and associated with ERG-fusion positive and PTEN deleted prostate cancers.
Steurer et al., Hamburg, Germany. In Int J Cancer, Apr 2016
Zinc-alpha 2-glycoprotein (AZGP1) is involved in lipid metabolism and was suggested as a candidate prognostic biomarker in prostate cancer.
Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites.
McDermott et al., London, United Kingdom. In Biochem J, Feb 2016
Zinc α2 glycoprotein (ZAG) is an adipokine with a class I MHC protein fold and is associated with obesity and diabetes.
Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway.
Huang et al., Nanjing, China. In J Cancer Res Clin Oncol, Jan 2016
Expression of PI3K, Akt, p-Akt, mTOR, p-mTOR, FASN, and AZGP1 was measured using western blotting and qPCR.
Supporting evidences for potential biomarkers of endometriosis detected in peripheral blood.
Baldi et al., Roma, Italy. In Data Brief, Dec 2015
Evaluation of these two proteins, together with the already described Zn-alpha2-glycoprotein [1], could help in the early identification of endometriosis patients.
Human plasma protein N-glycosylation.
Wuhrer et al., Leiden, Netherlands. In Glycoconj J, Dec 2015
Thus, as the assessment of protein glycosylation is becoming a major element in clinical and biopharmaceutical research, this review aims to convey the current state of knowledge on the N-glycosylation of the major plasma glycoproteins alpha-1-acid glycoprotein, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein, alpha-2-macroglobulin, antithrombin-III, apolipoprotein B-100, apolipoprotein D, apolipoprotein F, beta-2-glycoprotein 1, ceruloplasmin, fibrinogen, immunoglobulin (Ig) A, IgG, IgM, haptoglobin, hemopexin, histidine-rich glycoprotein, kininogen-1, serotransferrin, vitronectin, and zinc-alpha-2-glycoprotein. In addition, the less abundant immunoglobulins D and E are included because of their major relevance in immunology and biopharmaceutical research.
Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition.
Feron et al., Dijon, France. In J Proteomics, Nov 2015
Finally, salivary profiles of ED patients were partly comparable to those of subjects with exacerbated gustatory sensitivities, in particular with reduced abundance of cystatin SN and higher abundance of zinc-alpha-2-glycoprotein. Whether this translates taste hypersensitivity and contributes to the eating difficulties deserves further attention.
Optimal aluminum/zirconium: Protein interactions for predicting antiperspirant efficacy using zeta potential measurements.
Pan et al., In J Cosmet Sci, Mar 2015
The interactions between commercial antiperspirant (AP) salts [aluminum chlorohydrate (ACH), activated ACH, aluminum sesquichlorohydrate (ASCH), zirconium aluminum glycine (ZAG), activated ZAG), pure aluminum polyoxocations (Al13-mer, Al30-mer), and the zirconium(IV)-glycine complex Zr6 (O)4 (OH)4 (H2O)8 (Gly)8]12+(-) (CP-2 or ZG) with Bovine serum albumin (BSA) were studied using zeta potential and turbidity measurements.
Effects of sitagliptin on circulating zinc-α2-glycoprotein levels in newly diagnosed type 2 diabetes patients: a randomized trial.
Yang et al., Jackson, United States. In Eur J Endocrinol, Feb 2015
OBJECTIVE: Zinc-α2-glycoprotein (ZAG) has recently been characterized as a potent metabolic regulator.
Primary myeloma interaction and growth in coculture with healthy donor hematopoietic bone marrow.
Yaccoby et al., Little Rock, United States. In Bmc Cancer, 2014
Levels of extracellular matrix factors (e.g., MMP1, HMCN1, COL3A1, ACAN) and immunomodulatory factors (e.g., IFI16, LILRB4, PTPN6, AZGP1) were changed in the coculture system.
Adipokines in gestational diabetes.
Stumvoll et al., Leipzig, Germany. In Lancet Diabetes Endocrinol, 2014
Recent studies have assessed the role of various adipokines including leptin, adiponectin, tumour necrosis factor α (TNFα), adipocyte fatty acid-binding protein (AFABP), retinol-binding protein 4 (RBP4), resistin, NAMPT, SERPINA12, chemerin, progranulin, FGF-21, TIMP1, LCN2, AZGP1, apelin (APLN), and omentin in gestational diabetes.
Obesity, inflammation, and lung injury (OILI): the good.
Wang, Buffalo, United States. In Mediators Inflamm, 2013
Zinc-α 2-glycoprotein (ZAG), vaspin, IL-10, interleukin-1 receptor antagonist (IL-1RA), transforming growth factor β (TGF-β1), and growth differentiation factor 15 (GDF15) are also regarded as anti-inflammatories.
Zinc-α2-glycoprotein as a marker of fat catabolism in humans.
Tedeschi et al., Parma, Italy. In Curr Opin Clin Nutr Metab Care, 2013
Zinc-α2-glycoprotein (ZAG), firstly isolated in human plasma 50 years ago, has emerged as a novel adipokine, which plays an important role in mobilization and utilization of lipids.
The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules.
Luoma et al., Chicago, United States. In Annu Rev Immunol, 2012
Well adapted for antigen presentation, as seen for peptides in the classical MHC molecules and for lipids in CD1 molecules, the MHC fold has also been modified to perform Fc-receptor activity (e.g., FcRn) and for roles in host homeostasis (e.g., with HFE and ZAG).
Urinary proteomics revealed prostaglandin H(2)D-isomerase, not Zn-α2-glycoprotein, as a biomarker for active lupus nephritis.
Avihingsanon et al., Bangkok, Thailand. In J Proteomics, 2012
Urinary PGDS, not ZA2G, may serve as a biomarker for active LN and upon validation in larger studies, may become the non-invasive test to evaluate the disease activity in future management of LN.
rs4215 SNP in zinc-α2-glycoprotein gene is associated with obesity in Chinese north Han population.
Gong et al., Beijing, China. In Gene, 2012
The genotypes of rs4215 in ZAG gene are significantly associated with obesity in Chinese north Han population. GG genotype subjects in rs4215 site have an increased susceptibility to obesity when compared with the AA+AG genotype subjects.
Con A-binding protein Zn-α2-glycoprotein on human sperm membrane is related to acrosome reaction and sperm fertility.
Ding et al., Shanghai, China. In Int J Androl, 2012
These results indicate that ZAG, which is present on the human sperm membrane, plays a critical role in the acrosome reaction and subsequently, may be involved in sperm fertility.
Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients.
Tinahones et al., Tarragona, Spain. In Plos One, 2011
ZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance.
Downregulation of fetuin-B and zinc-α2-glycoprotein is linked to impaired fatty acid metabolism in liver cells.
Yun et al., Taegu, South Korea. In Cell Physiol Biochem, 2011
Reduced expression of AZGP1 led to a significant increase in the expression of lipogenic genes, thereby resulting in higher lipid levels.
Lipid mobilization in cachexia: mechanisms and mediators.
Bing, Liverpool, United Kingdom. In Curr Opin Support Palliat Care, 2011
In addition to cytokines, other factors such as zinc-α2-glycoprotein (ZAG) are implicated in adipose atrophy.
Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.
Bjorkman et al., Pasadena, United States. In Science, 1999
Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids.
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