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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Neuropeptide Y receptor Y2

Y2 receptor, neuropeptide Y Y2 receptor, NPY2R
Top mentioned proteins: Neuropeptide, neuropeptide Y, V1a, HAD, ACID
Papers on Y2 receptor
APOH interacts with FTO to predispose to healthy thinness.
Hunt et al., Salt Lake City, United States. In Hum Genet, Feb 2016
For validation, we tested the candidates for association with healthy thinness in additional pedigree members while accounting for effects of obesity-associated genes: NPFFR2, NPY2R, FTO, and MC4R.
Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors.
Kokaia et al., Lund, Sweden. In Neurobiol Dis, Feb 2016
In the present study, a conceptually novel framework reflecting a plausible clinical trial for gene therapy of temporal lobe epilepsy was explored: We investigated (i) whether the post intrahippocampal kainate-induced status epilepticus (SE) model of chronic epilepsy in rats could be clinically relevant; and (ii) whether a translationally designed neuropeptide Y (NPY)/Y2 receptor-based gene therapy approach targeting only the seizure-generating focus unilaterally can decrease seizure frequency in this chronic model of epilepsy.
Metabolism of Peptide YY 3-36 in G├Âttingen Mini-pig and Rhesus Monkey.
Jorgensen et al., Denmark. In Peptides, Feb 2016
UNASSIGNED: Peptide YY 3-36-amide (PYY3-36) is a peptide hormone, which is known to decrease appetite and food-intake by activation of the Y2 receptor.
Chronic administration of methamphetamine promotes atherosclerosis formation in ApoE-/- knockout mice fed normal diet.
Gu et al., Wuhan, China. In Atherosclerosis, Nov 2015
Moreover, mRNA expressions of NPY1R, NPY2R and NPY5R in aortic and myocardial tissue were also significantly upregulated in M4 and M8 groups.
The role of NPY in learning and memory.
Woldbye et al., Copenhagen, Denmark. In Neuropeptides, Nov 2015
In addition, NPY impairs acquisition but enhances consolidation and retention in models depending on spatial and discriminative types of associative explicit memory, presumably involving Y2 receptor-mediated regulations of hippocampal excitatory transmission.
Neuropeptide Y: A stressful review.
Holzer et al., Graz, Austria. In Neuropeptides, Oct 2015
The biological actions of NPY in mammals are mediated by the Y1, Y2, Y4 and Y5 receptors, Y1 receptor stimulation being anxiolytic whereas Y2 receptor activation is anxiogenic.
Y2 receptor signalling in NPY neurons controls bone formation and fasting induced feeding but not spontaneous feeding.
Herzog et al., Sydney, Australia. In Neuropeptides, Oct 2015
Importantly, another known function of central Y2 receptor signalling, the suppression of bone formation is conserved in this conditional model with whole body bone mineral content being decreased.
The role of Neuropeptide Y in fear conditioning and extinction.
Sperk et al., Innsbruck, Austria. In Neuropeptides, Oct 2015
In particular the inhibition of long-range central amygdala output neurons may result in a Y2 receptor-dependent suppression of fear.
Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala.
Tasan et al., Innsbruck, Austria. In Brain Struct Funct, Oct 2015
Interestingly, NPY neurons did not co-localize with the Y2 receptor.
Vagal Sensory Neuron Subtypes that Differentially Control Breathing.
Liberles et al., Boston, United States. In Cell, May 2015
Here, we identify two populations of mouse vagus nerve afferents (P2ry1, Npy2r), each a few hundred neurons, that exert powerful and opposing effects on breathing.
Ligands of the neuropeptide Y Y2 receptor.
Roberts et al., Los Angeles, United States. In Bioorg Med Chem Lett, 2014
Y2 receptor is the most abundant Y subtype receptor in the central nervous system and implicated with food intake, bone formation, affective disorders, alcohol and drugs of abuse, epilepsy, pain, and cancer.
Leung, Bethesda, United States. In Unknown Journal, 2012
One of these antagonists, Y1-973, is reported to have IC50 values of 0.13 nM for human NPY1R and >10,000 nM for human NPY2R, NPY4R, and NPY5R.
Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of ╬▓-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors.
Holliday et al., Nottingham, United Kingdom. In Biochim Biophys Acta, 2012
The influence of beta-arrestin adaptors and endocytosis mechanisms on plasma membrane diffusion and particle brightness of GFP-tagged neuropeptide Y (NPY) receptors, was investigated.
Assessment of a fully active class A G protein-coupled receptor isolated from in vitro folding.
Schmidt et al., Leipzig, Germany. In Biochemistry, 2011
protocol for the preparation of fully active Y2 G protein-coupled receptor
Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.
Adams et al., Salt Lake City, United States. In Obesity (silver Spring), 2011
Four genetic loci were strongly and independently associated with obesity, NPY2R, NPFFR2, MC4R, and FTO.
Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes.
Larhammar et al., Uppsala, Sweden. In Neuropeptides, 2011
Data present a site-directed mutagenesis study of four amino acid positions in the human Y2 receptor.
Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells.
Buschauer et al., Regensburg, Germany. In J Recept Signal Transduct Res, 2011
Results report on the functional reconstitution of the hY(2)R and the hY(4)R in Sf9 insect cells using the baculovirus system.
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome.
Zukowska et al., Washington, D.C., United States. In Nat Med, 2007
Stressors such as exposure to cold or aggression lead to the release of NPY from sympathetic nerves, which in turn upregulates NPY and its Y2 receptors (NPY2R) in a glucocorticoid-dependent manner in the abdominal fat.
Gut hormone PYY(3-36) physiologically inhibits food intake.
Bloom et al., London, United Kingdom. In Nature, 2002
The NPY Y2 receptor (Y2R), a putative inhibitory presynaptic receptor, is highly expressed on NPY neurons in the arcuate nucleus, which is accessible to peripheral hormones.
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor.
Ernfors et al., Stockholm, Sweden. In Nat Med, 1999
Little is known of the role of the Y2 receptor in mediating the different NPY effects.
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