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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

KEM1 Kem1p

SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: exoribonuclease, CAN, caspase-3, ACID, selenoprotein P
Papers on XRN1
RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1.
Newbury et al., Brighton, United Kingdom. In Nucleic Acids Res, Feb 2016
Pacman/XRN1 is a highly conserved cytoplasmic exoribonuclease which degrades RNAs in a 5'-3' direction.
Rotavirus disrupts cytoplasmic P bodies during infection.
Chawla-Sarkar et al., Calcutta, India. In Virus Res, Jan 2016
The disruption occurred by more than one different mechanism where deadenylating P body component Pan3 was degraded by rotavirus NSP1 and exonuclease XRN1 along with the decapping enzyme hDCP1a were relocalized from cytoplasm to nucleus.
Complex host genetic susceptibility to Staphylococcus aureus infections.
Schrodi et al., Marshfield, United States. In Trends Microbiol, Sep 2015
GWASs for all S. aureus diseases have suggested roles for DAPK3, a kinase, and XRN1, a nuclease, while CDON could have a role in complicated bacteremia.
XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides.
Obika et al., Suita, Japan. In Biochem Biophys Res Commun, Sep 2015
To better understand this degradation pathway, we depleted the expression of two major 5' to 3' exoribonucleases (XRNs), named XRN1 and XRN2, and analyzed the levels of 3' fragments of the target RNAs in vitro.
Dengue Non-coding RNA: TRIMmed for Transmission.
Pijlman et al., Wageningen, Netherlands. In Cell Host Microbe, Sep 2015
Dengue virus RNA is trimmed by the 5'→3' exoribonuclease XRN1 to produce an abundant, non-coding subgenomic flavivirus RNA (sfRNA) in infected cells.
Functional non-coding RNAs derived from the flavivirus 3' untranslated region.
Khromykh et al., Brisbane, Australia. In Virus Res, Sep 2015
In this review we summarize published data from studies with WNV, YFV, DENV, JEV, and MVEV on sfRNA production following incomplete degradation of the viral genomic RNA by the cellular 5'-3' exoribonuclease 1 (XRN1), RNA structural elements involved in stalling XRN1 to generate sfRNA, and functions of sfRNA in modulating cellular mRNA decay and RNAi pathways as well as in modulating anti-viral type I interferon response.
RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast.
Yanagida et al., Okinawa, Japan. In Genes Cells, Jun 2015
First, condensin's enrichment on mitotically activated genes was abolished by deleting the sep1(+) gene that encodes an M-phase-specific forkhead transcription factor.
Degradation of class E MADS-domain transcription factors in Arabidopsis by a phytoplasmal effector, phyllogen.
Namba et al., Tokyo, Japan. In Plant Signal Behav, 2014
Members of the SEPALLATA (SEP) gene sub-family encode class E floral homeotic MADS-domain transcription factors (MADS TFs) that specify the identity of floral organs.
Noncoding subgenomic flavivirus RNA: multiple functions in West Nile virus pathogenesis and modulation of host responses.
Khromykh et al., Brisbane, Australia. In Viruses, 2014
sfRNA is a product of incomplete degradation of genomic RNA by the cell 5'-3' exoribonuclease XRN1 which stalls at highly ordered secondary RNA structures at the beginning of the 3'UTR.
The role of disordered protein regions in the assembly of decapping complexes and RNP granules.
Izaurralde et al., Tübingen, Germany. In Genes Dev, 2014
The removal of the 5' cap structure by the decapping enzyme DCP2 inhibits translation and generally commits the mRNA to irreversible 5'-to-3' exonucleolytic degradation by XRN1.
XRN 5'→3' exoribonucleases: structure, mechanisms and functions.
Green et al., Newark, United States. In Biochim Biophys Acta, 2013
Highly conserved across species, the family is typically represented by one cytoplasmic enzyme (XRN1/PACMAN or XRN4) and one or more nuclear enzymes (XRN2/RAT1 and XRN3).
Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast.
Bénard et al., Paris, France. In Proc Natl Acad Sci U S A, 2012
We propose that the activation of Xrn1 by Dcs1 is important for respiration.
XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast.
Morillon et al., Gif-sur-Yvette, France. In Nature, 2011
identification of a novel class of 1,658 Xrn1-sensitive unstable transcripts (XUTs) in which 66% are antisense to open reading frames; antisense ncRNA-mediated regulation is a general regulatory pathway for gene expression in S. cerevisiae
Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.
Doudna et al., Berkeley, United States. In Mol Cell, 2011
analysis of coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay
Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.
Ursini et al., Napoli, Italy. In J Biol Chem, 2010
WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
P-body components are required for Ty1 retrotransposition during assembly of retrotransposition-competent virus-like particles.
Garfinkel et al., Frederick, United States. In Mol Cell Biol, 2010
Kem1p may prevent the aggregation of Ty1 antisense and mRNAs
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila.
Izaurralde et al., Heidelberg, Germany. In Nature, 2004
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage: the resulting 5' fragment is rapidly degraded by exonucleolytic digestion by the exosome, whereas the 3' fragment is degraded by XRN1
B and C floral organ identity functions require SEPALLATA MADS-box genes.
Yanofsky et al., Los Angeles, United States. In Nature, 2000
Here we show that the activities of the B and C organ-identity genes require the activities of three closely related and functionally redundant MADS-box genes, SEPALLATA1/2/3 (SEP1/2/3).
Prions and RNA viruses of Saccharomyces cerevisiae.
Wickner, Bethesda, United States. In Annu Rev Genet, 1995
SKI1/XRN1 is a 5'--> 3' exoribonuclease that degrades uncapped mRNAs.
The yeast KEM1 gene encodes a nuclease specific for G4 tetraplex DNA: implication of in vivo functions for this novel DNA structure.
Gilbert et al., Cambridge, United States. In Cell, 1994
We purify this activity to homogeneity and show it to be the product of the S. cerevisiae KEM1 gene, which is also known as SEP1, DST2, XRN1, and RAR5.
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