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X-ray repair complementing defective repair in Chinese hamster cells 3

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: XRCC1, XPD, Rad51, HAD, AGE
Papers on XRCC3
Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study.
da Costa Miguel et al., Natal, Brazil. In Arch Oral Biol, Jan 2016
OBJECTIVE: to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC).
XRCC3 Thr241Met and XPD Lys751Gln gene polymorphisms and risk of clear cell renal cell carcinoma.
Borda et al., Târgu-Mureş, Romania. In Cancer Biomark, Jan 2016
Despite the fact that XRCC3 and XPD DNA repair genes association with several types of cancer was widely studied, their role in the development of clear cell renal cell carcinoma (CCRCC) has not been established in the European population.
Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility.
Liu et al., Jingmen, China. In Genet Mol Res, Dec 2015
Currently, most research has investigated the GSTM1, XRCC1, XRCC3, CYP2D6, and C188T genes.
DNA repair gene XRCC3 Thr241Met polymorphisms and lung cancer risk: a meta-analysis.
Zhao-Yu et al., Wuhan, China. In Bull Cancer, Apr 2015
BACKGROUND: The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate gene for cancer susceptibility, and a large amount studies have examined the association of the rs861539 in XRCC3 (Thr241Met) with lung cancer risk in various populations.
Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population.
Liu et al., Hohhot, China. In Genet Mol Res, 2014
We assessed the association between XRCC3 Thr241Met polymorphism and susceptibility to osteosarcoma in a Chinese population.
Association of XRCC3 gene rs861539 polymorphism with gastric cancer risk: evidence from a case-control study and a meta-analysis.
Wang et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
The association between the X-ray repair cross-complementing group 3 (XRCC3) gene Thr241Met polymorphism (rs861539) and gastric cancer has been widely evaluated, but a definitive answer is so far lacking.
Association Between X-Ray Cross-complementing Group 3 (XRCC3) Thr241Met Polymorphism and Risk of Thyroid Cancer: A Meta-Analysis.
Zhang et al., Yancheng, China. In Med Sci Monit, 2014
BACKGROUND The X-ray cross-complementing group 3 (XRCC3) gene encodes a protein that plays an important role in homologous recombination repair (HRR) of DNA double-strand break (DSB).
Association between DNA repair gene polymorphisms and risk of glioma: a systematic review and meta-analysis.
Feychting et al., Stockholm, Sweden. In Neuro Oncol, 2014
No evidence of significant associations between ERCC2 rs1799793, OGG1 rs1052133, XRCC1 rs25489, XRCC1 rs1799782, or XRCC3 rs861539 and risk of glioma was observed.
Genetic variants and risk of cervical cancer: epidemiological evidence, meta-analysis and research review.
Wang et al., Jinan, China. In Bjog, 2014
The epidemiological evidence of the association was graded as strong for four variants in CTLA4 and HLA DQB1, moderate for five variants in IL-1B, IL-10, XRCC3 and HLA DQA1, and weak for 10 variants.
XRCC3 Thr241Met polymorphism and gastric cancer susceptibility: a meta-analysis.
Wu et al., Chengdu, China. In Clin Res Hepatol Gastroenterol, 2014
BACKGROUND AND OBJECTIVE: X-ray repair cross-complementing group 3 (XRCC3) is responsible for maintaining the integrity of the genome, playing a critical role in protecting it against mutations which lead to cancer.
Genetic variability of Xrcc3 and Rad51 modulates the risk of head and neck cancer.
Wasowicz et al., Łódź, Poland. In Gene, 2012
genetic variability of Xrcc3 and/or Rad51 genes might be of relevance with respect to HNC risk
Prediction of genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 in the survival of colorectal cancer receiving chemotherapy in the Chinese population.
Hu et al., Nanzhou, China. In Hepatogastroenterology, 2012
XRCC1 and XRCC3 gene polymorphisms are useful as a surrogate marker of clinical outcome in colorectal cancer with 5-FU/oxaliplatin combination chemotherapy in the Chinese population.
[The polymorphism of DNA repair genes XRCC1, XRCC3 and the level of chromosomal aberrations in the Uranium workers].
Vorobtsova et al., In Radiats Biol Radioecol, 2012
The frequency of chromosomal aberrations in heterozygous carriers of the XRCC3gene Thr/Met was lower than in the homozygous carriers of the wild type Thr/Thr (p < 0.001).
Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population.
Liu et al., Shenyang, China. In Asian Pac J Cancer Prev, 2011
XRCC3 241Met allele polymorphism was found to be associated with an increased colorectal cancer risk.
The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland.
Sporny et al., Łódź, Poland. In Eur J Gynaecol Oncol, 2011
The results support the hypothesis that polymorphism of XRCC3 may be associated with the incidence of sporadic breast cancer in Polish women.
Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.
Zheng et al., Nashville, United States. In Lancet Oncol, 2011
Cumulative epidemiological evidence of an association was graded as strong for ten variants in six genes (ATM, CASP8, CHEK2, CTLA4, NBN, and TP53), moderate for four variants in four genes (ATM, CYP19A1, TERT, and XRCC3), and weak for 37 variants.
Phase II studies of gemcitabine and cisplatin in heavily and minimally pretreated metastatic breast cancer.
Albain et al., Sacramento, United States. In J Clin Oncol, 2009
In a subset of 55 patients, the xeroderma pigmentosum group D (XPD)-751, x-ray cross-complementing group 3 (XRCC3) and cytidine deaminase polymorphisms were significantly associated with clinical outcomes.
Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer.
Lafrenie et al., Greater Sudbury, Canada. In J Clin Oncol, 2007
XRCC1-01, XRCC3-01, and CCND1-01 may be predictive of survival outcome in patients with metastatic breast cancer treated with DNA-damaging chemotherapy
Pharmacogenetic profiling and clinical outcome of patients with advanced gastric cancer treated with palliative chemotherapy.
Magnani et al., Urbino, Italy. In J Clin Oncol, 2006
PATIENTS AND METHODS: Peripheral blood samples from 175 prospectively enrolled AGC patients treated with fluorouracil/cisplatin palliative chemotherapy were used for genotyping 13 polymorphisms in nine genes (TS, MTHFR, XPD, ERCC1, XRCC1, XRCC3, GSTPI, GSTTI, GSTMI).
Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors.
Benítez et al., Madrid, Spain. In J Clin Oncol, 2005
MATERIALS AND METHODS: We have studied two tissue microarrays that include 103 familial and 104 sporadic breast tumors, with a panel of DNA repair markers including ATM, CHEK2, RAD51, RAD50, XRCC3, and proliferating cell nuclear antigen.
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