gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

X-ray repair complementing defective repair in Chinese hamster cells 1

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, POLYMERASE, AGE, V1a
Papers using XRCC1 antibodies
Association between polymorphisms of DNA repair gene XRCC1 and DNA damage in asbestos-exposed workers.
Kane Agnes B. et al., In Environmental Health Perspectives, 2005
... PCR/RFLP analysis for XRCC1 SNPs.
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
Irani Kaikobad et al., In Nucleic Acids Research, 1996
... Antibodies against acetyl-lysine, Ac-K 382-p53 and XRCC1 were purchased from Cell Signaling Technology (Beverly, MA) ...
Papers on XRCC1
Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma.
Moriyama et al., Ōita, Japan. In Cancer Sci, Feb 2016
In functional assays, exogenous WDR20 significantly inhibited the growth of RCC cell lines and induced apoptosis.
Role of NADH Dehydrogenase (Ubiquinone) 1 alpha subcomplex 4-like 2 in clear cell renal cell carcinoma.
Gudas et al., Nottingham, United Kingdom. In Clin Cancer Res, Feb 2016
Additionally, we demonstrated that NDUFA4L2 is a HIF1α target in ccRCC and that NDUFA4L2 knockdown has a profound anti-proliferative effect, alters metabolic pathways, and causes major stress in cultured RCC cells.
Atezolizumab, an Anti-Programmed Death-Ligand 1 Antibody, in Metastatic Renal Cell Carcinoma: Long-Term Safety, Clinical Activity, and Immune Correlates From a Phase Ia Study.
Powles et al., Boston, United States. In J Clin Oncol, Feb 2016
PURPOSE: The objective was to determine the safety and clinical activity of atezolizumab (MPDL3280A), a humanized programmed death-ligand 1 (PD-L1) antibody, in renal cell carcinoma (RCC).
Amygdalin blocks the in vitro adhesion and invasion of renal cell carcinoma cells by an integrin-dependent mechanism.
Blaheta et al., Frankfurt am Main, Germany. In Int J Mol Med, Feb 2016
In this study, to determine whether amygdalin exerts antitumor effects on renal cell carcinoma (RCC) cells, its impact on RCC metastatic activity was investigated.
Genetic polymorphisms in the DNA repair gene, XRCC1 associate with non-Hodgkin lymphoma susceptibility: A systematic review and meta-analysis.
Li et al., Changchun, China. In Eur J Med Genet, Jan 2016
UNASSIGNED: A DNA repair protein, X-ray repair cross-complementing group 1 (XRCC1), has been implicated in the development of multiple cancers, including non-Hodgkin lymphoma (NHL).
Interaction of the CYP1A1 gene polymorphism and smoking in non-small cell lung cancer susceptibility.
Liu et al., Jingmen, China. In Genet Mol Res, Dec 2015
Currently, most research has investigated the GSTM1, XRCC1, XRCC3, CYP2D6, and C188T genes.
Targeting PD-1/PD-L1 in the treatment of metastatic renal cell carcinoma.
McDermott et al., Boston, United States. In Ther Adv Urol, Dec 2015
Immunostimulatory therapies have been a cornerstone of treatment for metastatic renal cell carcinoma (RCC) since the 1990s.
Cardiopulmonary bypass-assisted surgery for the treatment of Xp11.2 translocation/TFE3 gene fusion renal cell carcinoma with a tumor thrombus within the inferior vena cava: A case report.
Guo et al., Nanjing, China. In Oncol Lett, Dec 2015
UNASSIGNED: Renal cell carcinoma (RCC) accounts for 85-90% of kidney cancers, which in turn account for 2-3% of all malignant tumors in adults.
Rational selection of predictive pharmacogenomics test for the Fluoropyrimidine/Oxaliplatin based therapy.
Berretta et al., Napoli, Italy. In Eur Rev Med Pharmacol Sci, Nov 2015
MATERIALS AND METHODS: A systematic literature search of the MEDLINE, EMBASE, and Cochrane databases was conducted to identify all clinical studies of any association between DPYD and 5-FU correlated to allelic status of 6 validated polymorphisms in five genes Dihydropyrimidine Dehydrogenase (DPYD), Thymidylate Synthase (TYMS), Glutathione S-Transferase (GSTP1), and DNA-repair genes (ERCC2 and XRCC1).
PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane.
Lu et al., Stanford, United States. In Cell Metab, Feb 2015
How RCC biogenesis is regulated in metazoans is poorly understood.
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
Seshagiri et al., San Francisco, United States. In Nat Genet, 2015
Finally, we observed upregulation of the anti-apoptotic factor BIRC7 in MiTF-high RCC tumors, suggesting a potential therapeutic role for BIRC7 inhibitors.
Profile of nintedanib in the treatment of solid tumors: the evidence to date.
Schwarz et al., South Bend, United States. In Onco Targets Ther, 2014
While most of these agents are approved in combination with cytotoxic chemotherapy for indications including metastatic colorectal cancer, non-small-cell lung cancer, breast cancer, renal cell carcinoma (RCC), and gastric cancer, some are used as approved monotherapy for advanced RCC, hepatocellular carcinoma and medullary thyroid cancer.
Clinicopathological and prognostic value of programmed death ligand-1 (PD-L1) in renal cell carcinoma: a meta-analysis.
Liu et al., Beijing, China. In Int J Clin Exp Med, 2014
The objective of this study is to assess the clinical value of PD-L1 as a novel prognostic biomarker of renal cell carcinoma (RCC).
Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression.
Biswas et al., Singapore, Singapore. In Immunity, 2014
We used molecular profiling combined with functional assays to investigate the role of these cells in human renal cell carcinoma (RCC).
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
Czyzyk-Krzeska et al., Cincinnati, United States. In Cancer Cell, 2014
Increased expression of TRPM3 in RCC leads to Ca(2+) influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation.
Polymorphisms of base-excision repair genes hOGG1 326cys and XRCC1 280His increase hepatocellular carcinoma risk.
Chen et al., Chongqing, China. In Dig Dis Sci, 2012
The study demonstrated the association of hOGG1 and XRCC1 repair gene polymorphisms with hepatocellular carcinoma (HCC) risk; studies are needed before they can be used as a biomarker for assessing HCC risk.
No evidence of association between the synonymous polymorphisms in XRCC1 and ERCC2 and breast cancer susceptibility among nonsmoking Chinese.
Sun et al., Shenyang, China. In Gene, 2012
The data suggested that XRCC1 Pro206Pro and ERCC2 Arg156Arg do not substantially influence breast cancer susceptibility among nonsmoking Chinese. The two loci were at weak linkage disequilibrium.
The cAMP signaling system inhibits the repair of γ-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells.
Juhnn et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
cAMP signaling system inhibits the repair of gamma-ray-induced DNA damage by promoting the ubiquitin-proteasome dependent degradation of XRCC1 in an Epac1-dependent pathway in lung cancer cells.
Prediction of genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 in the survival of colorectal cancer receiving chemotherapy in the Chinese population.
Hu et al., Nanzhou, China. In Hepatogastroenterology, 2012
XRCC1 and XRCC3 gene polymorphisms are useful as a surrogate marker of clinical outcome in colorectal cancer with 5-FU/oxaliplatin combination chemotherapy in the Chinese population.
[The polymorphism of DNA repair genes XRCC1, XRCC3 and the level of chromosomal aberrations in the Uranium workers].
Vorobtsova et al., In Radiats Biol Radioecol, 2012
The Gln/Gln genotype of gene XRCC1 was associated with a significant increase in the number of chromosomal aberrations as compared to the corresponding homozygous wild type Arg/Arg
share on facebooktweetadd +1mail to friends