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REX4, RNA exonuclease 4 homolog

XPMC2, XPMC2H, REX4, Rex4p, hPMC2
Top mentioned proteins: POLYMERASE, CAN, Dlx5, Tec, Rex-1
Papers on XPMC2
Downregulation of hPMC2 imparts chemotherapeutic sensitivity to alkylating agents in breast cancer cells.
Montano et al., Cleveland, United States. In Cancer Biol Ther, 2014
We have shown previously that a novel protein, human homolog of Xenopus gene which Prevents Mitotic Catastrophe (hPMC2) has a role in the repair of estrogen-induced abasic sites.
Sripathy et al., Cleveland, United States. In Drug Discov Today Dis Mech, 2011
This upregulation of antioxidative stress enzymes requires Estrogen Receptor beta (ERβ) and human homolog of Xenopus gene which Prevents Mitotic Catastrophe (hPMC2).
The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites.
Montano et al., Cleveland, United States. In Oncogene, 2011
determined that the catalytic activity of hPMC2 is required for repair of abasic sites that result from estrogen-induced DNA damage
Synthetic peptides from conserved regions of the Plasmodium falciparum early transcribed membrane and ring exported proteins bind specifically to red blood cell proteins.
Patarroyo et al., Bogotá, Colombia. In Vaccine, 2009
Twelve binding peptides were identified (designated as HABPs): three were identified in REX1, two in REX2, one in REX3, two in REX4 and four in E-TRAMP 10.2.
hPMC2 is required for recruiting an ERbeta coactivator complex to mediate transcriptional upregulation of NQO1 and protection against oxidative DNA damage by tamoxifen.
Montano et al., Cleveland, United States. In Oncogene, 2008
We observe constitutive interaction between ERbeta and the novel protein hPMC2.
Functional analysis of p53 binding under differential stresses.
Giaccia et al., Stanford, United States. In Mol Cell Biol, 2006
Using gene-specific PCR analysis, we have verified an association with CGIs of the highest enrichment (> 2.5-fold) (REV3L, XPMC2H, HNRPUL1, TOR1AIP1, glutathione peroxidase 1, and SCFD2), with CGIs of intermediate enrichment (> 2.2-fold) (COX7A2L, SYVN1, and JAG2), and with CGIs of low enrichment (> 2.0-fold) (MYC and PCNA).
Genetic rescue of a Toxoplasma gondii conditional cell cycle mutant.
Striepen et al., Bozeman, United States. In Mol Microbiol, 2005
A single T. gondii gene encoding the protein homologue of XPMC2 was responsible for genetic rescue of the temperature-sensitive defect in ts11C9 parasites.
The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.
Raué et al., Amsterdam, Netherlands. In Rna, 2004
data link three RNA catabolic enzymes, Rex4p, Rnt1p, and Dbr1p, to ITS1 processing and the relative production of 5.8SS and 5.8SL rRNA
Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p.
Raué et al., Amsterdam, Netherlands. In Nucleic Acids Res, 2002
A synthetic lethality screen using the rrp5-Delta3 and rrp-Delta4 mutations identified the REX4 gene, which encodes a non-essential protein belonging to a class of related yeast proteins that includes several known 3'-->5' exonucleases.
Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity.
Bianco et al., Cleveland, United States. In J Biol Chem, 2000
One of these protein factors, hPMC2 (human homolog of Xenopus gene which prevents mitotic catastrophe), directly binds to the EpRE and interacts with the ER in yeast genetic screening and in vitro assays.
The application of high density microarray for analysis of mitogenic signaling and cell-cycle in the adrenal.
Pestell et al., United States. In Endocr Res, 2000
Analysis of AII signaling in adrenal cells by cDNA microarray demonstrated an induction of the human homologue of Xenopus XPMC2 (HXPMC2).
Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus.
Pentecost, Albany, United States. In J Steroid Biochem Mol Biol, 1998
The HEM45 protein has similarity to the bracket fungus protein FRT1 that can cause fruiting-body production and to a Xenopus product, XPMC2, that affects cell-cycle control.
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.
Mian et al., Berkeley, United States. In Nucleic Acids Res, 1998
Results indicate that it is also present in the RNase T family; Borrelia burgdorferi P93 protein, an immunodominant antigen in Lyme disease; bacteriophage T4 dexA and Escherichia coli exonuclease I, processive 3'-->5' exodeoxyribonucleases that degrade single-stranded DNA; Bacillus subtilis dinG, a probable helicase involved in DNA repair and possibly replication, and peptide synthase 1; Saccharomyces cerevisiae Pab1p-dependent poly(A) nuclease PAN2 subunit, required for shortening mRNA poly(A) tails; Caenorhabditis elegans and Mus musculus CAF1, transcription factor CCR4-associated factor 1; Xenopus laevis XPMC2, prevention of mitotic catastrophe in fission yeast; Drosophila melanogaster egalitarian, oocyte specification and axis determination, and exuperantia, establishment of oocyte polarity; H.sapiens HEM45, expressed in tumour cell lines and uterus and regulated by oestrogen; and 31 open reading frames including one in Methanococcus jannaschii .
Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1.
Kwiatkowski et al., Boston, United States. In Genomics, 1997
XPMC2 is a Xenopus gene identified on the basis of its ability to correct a mitotic defect in fission yeast.
Molecular cloning of a new interferon-induced PML nuclear body-associated protein.
Mechti et al., Montpellier, France. In J Biol Chem, 1997
In the course of this study, we have isolated a human cDNA that codes for a 20-kDa protein sharing striking homology with the product of the Xenopus laevis XPMC2 gene.
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