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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Xeroderma pigmentosum, complementation group C

XPC, p125, Rad4
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: XPA, CAN, HAD, XPD, XPG
Papers using XPC antibodies
Polymorphisms of DNA repair genes are risk factors for prostate cancer
Mittal Rama Devi et al., In The Indian Journal of Medical Research, 2006
... XPC exon 15 (A>C) was genotyped by PCR-RFLP method using PvuII (New England Biolabs, Beverly, MA, USA) restriction ...
The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH.
Hoeijmakers Jan H. J., In PLoS Biology, 2001
... ), and XPC (target sequence 5′-TAGCAAATGGCTTCTATCGAA-3′) were purchased from Qiagen.
Papers on XPC
Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation.
Naegeli et al., Zürich, Switzerland. In Cell Mol Life Sci, Feb 2016
Xeroderma pigmentosum group C (XPC) protein provides the promiscuous damage sensor that initiates this versatile NER reaction through the sequential recruitment of DNA helicases and endonucleases, which in turn recognize and excise insulting base adducts.
Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population.
Lazar et al., Târgu-Mureş, Romania. In Tumour Biol, Feb 2016
UNASSIGNED: XPC, XPD, XPF, and XPG genes are implicated in the nucleotide excision repair (NER) system.
Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks.
Yuan et al., Shenyang, China. In Oncotarget, Feb 2016
P= 6.62 × 10-9); XPC rs2607775 CG genotype conferred a 1.73 increased odds of GC risk than non-cancer subjects compared with wild-type CC (OR=1.73,
New insights into the interaction of centrin with Sfi1.
Assairi et al., Orsay, France. In Biochim Biophys Acta, Feb 2016
UNASSIGNED: Centrin binds to Rad4(XPC) and Sfi1 through the hydrophobic motif W(1)xxL(4)xxxL(8) in the opposite orientation.
XPC: Going where no DNA damage sensor has gone before.
Gong et al., Miami, United States. In Dna Repair (amst), Dec 2015
Since the first discovery of its yeast homolog, Rad4, the involvement of XPC in cellular regulation has expanded considerably.
In vitro chromatin templates to study nucleotide excision repair.
Liu, West Lafayette, United States. In Dna Repair (amst), Dec 2015
At least three systems have been used to analyze the effect of nucleosome folding on nucleotide excision repair (NER) in vitro: (a) human cell extracts that have to rely on labeling of repair synthesis to monitor DNA repair, due to very low repair efficacy; (b) Xenopus oocyte nuclear extracts, that have very robust DNA repair efficacy, have been utilized to follow direct removal of DNA damage; (c) six purified human DNA repair factors (RPA, XPA, XPC, TFIIH, XPG, and XPF-ERCC1) that have been used to reconstitute excision repair in vitro.
DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient disease.
Sarasin et al., Villejuif, France. In Mutat Res, Jun 2015
We, particularly, developed the correction of XP-C skin cells using the fidelity of the homologous recombination pathway during repair of double-strand break (DSB) in the presence of XPC wild type sequences.
A Systematic Review and Meta-Analysis of Three Gene Variants Association with Risk of Prostate Cancer: An Update.
Wang et al., Huzhou, China. In Urol J, May 2015
The purpose of this study was to evaluate the relationship between single-nucleo­tide polymorphism (SNP) rs2228001 in xeroderma pigmentosum group C (XPC), SNP rs4073 in interleukin 8 (IL8), and SNP rs2279744 in mouse double minute 2 (MDM2) homolog gene with PCa susceptibility.
Lack of association between XPC Lys939Gln polymorphism and prostate cancer risk: an updated meta-analysis based on 3039 cases and 3253 controls.
Mo et al., Changzhou, China. In Int J Clin Exp Med, 2014
Several studies have evaluated the relationship between xeroderma pigmentosum complementation group C (XPC) variants and prostate cancer (PCa) risk.
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.
Bohr et al., Baltimore, United States. In Cell, 2014
Importantly, this pathogenesis appears common to ataxia-telangiectasia and Cockayne syndrome, two other DNA repair disorders with neurodegeneration, but absent in XPC, a DNA repair disorder without neurodegeneration.
Polymorphisms in DNA repair genes of XRCC1, XPA, XPC, XPD and associations with lung cancer risk in Chinese people.
Zhou et al., Tianjin, China. In Thorac Cancer, 2014
RESULTS: In single tag SNP analysis, XPA rs2808668, XPC rs2733533, and XPD rs1799787 were significantly associated with lung cancer susceptibility.
Interactions between cigarette smoking and XPC-PAT genetic polymorphism enhance bladder cancer risk.
Chen et al., Chongqing, China. In Oncol Rep, 2012
the XPC-PAT variant genotype exhibits a significantly increased risk for bladder cancer
Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses.
States et al., Louisville, United States. In Toxicol Sci, 2012
Sodium arsenite +/- hyperthermia sensitizes wild-type p53-expressing EOC cells to cisplatin by suppressing DNA repair protein XPC.
Poly (AT) polymorphism in the XPC gene and smoking enhance the risk of prostate cancer in a low-risk Chinese population.
Yang et al., Chongqing, China. In Cancer Genet, 2012
XPC-PolyAT polymorphisms are associated with a higher risk of developing prostate cancer.
Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a murine model of Cockayne syndrome.
Cleaver et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a cs-b xp-c murine model of Cockayne syndrome
Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
Vermeulen et al., Rotterdam, Netherlands. In J Cell Biol, 2012
Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex
eNERgizing pluripotent gene transcription.
Mostoslavsky et al., Boston, United States. In Cell Stem Cell, 2011
(2011) in the most recent issue of Cell demonstrates that the XPC/RAD23B/CETN2 nucleotide excision repair complex additionally functions as a transcriptional coactivator of Oct4/Sox2, critically regulating maintenance and reestablishment of stem cell pluripotency.
A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells.
Tjian et al., Berkeley, United States. In Cell, 2011
Purification, identification, and reconstitution of SCC revealed this coactivator to be the trimeric XPC-nucleotide excision repair complex.
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases.
Montoya et al., Madrid, Spain. In Nature, 2008
These two molecules-Amel3-Amel4 and Ini3-Ini4-cleave DNA from the human XPC gene (xeroderma pigmentosum group C), in vitro and in vivo.
Recognition of DNA damage by the Rad4 nucleotide excision repair protein.
Pavletich et al., New York City, United States. In Nature, 2007
Here we present the crystal structure of the yeast XPC orthologue Rad4 bound to DNA containing a cyclobutane pyrimidine dimer (CPD) lesion.
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