GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Xeroderma pigmentosum, complementation group A
XPA, xeroderma pigmentosum complementation group A
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] (from
NCBI)
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Top mentioned proteins:
XPC, CAN, ERCC1, XPG, XPD
Papers on
XPA
Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks.
New
Shenyang, China. In Oncotarget, Feb 2016
XPA rs2808668 and drinking, DDB2 rs326222, rs3781619, rs830083 and smoking demonstrated significant interactions in AG; XPC rs2607775 had significant interaction with smoking in GC.
Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA.
New
New York City, United States. In J Biol Chem, Feb 2016
The ladders were not observed when NER was inhibited either by mouse monoclonal antibody [5F12] to human XPA, or in XPC(-/-) fibroblast cell extracts.
Covalent DNA-Protein Cross-linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells.
New
In Chem Res Toxicol, Jan 2016
Cys-NOR-N7G adduct numbers were higher in NER-deficient Xeroderma pigmentosum cells (XPA) as compared with repair proficient cells.
TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts.
New
London, United Kingdom. In Dna Repair (amst), Jan 2016
To this end we utilised Xpa -knockout (Xpa-Null) human TP53 knock-in (Hupki) embryo fibroblasts (HUFs).
In vitro chromatin templates to study nucleotide excision repair.
Review
New
West Lafayette, United States. In Dna Repair (amst), Dec 2015
At least three systems have been used to analyze the effect of nucleosome folding on nucleotide excision repair (NER) in vitro: (a) human cell extracts that have to rely on labeling of repair synthesis to monitor DNA repair, due to very low repair efficacy; (b) Xenopus oocyte nuclear extracts, that have very robust DNA repair efficacy, have been utilized to follow direct removal of DNA damage; (c) six purified human DNA repair factors (RPA, XPA, XPC, TFIIH, XPG, and XPF-ERCC1) that have been used to reconstitute excision repair in vitro.
The ERCC1 and ERCC4 (XPF) genes and gene products.
Review
New
United States. In Gene, Oct 2015
ERCC1-XPF interacts with other proteins including XPA, RPA, SLX4 and TRF2 to perform its functions.
Xeroderma pigmentosa: three new cases with an in depth review of the genetic and clinical characteristics of the disease.
Review
New
Atlanta, United States. In Fetal Pediatr Pathol, Apr 2015
Seven genes (XPA-XPG) have a defect in Nucletoide Excision Repair (NER), while the eighth gene XPV has a defect in polymerase η, which is responsible for replication of UV-damaged DNA to produce corrected daughter strands.
Overview of xeroderma pigmentosum proteins architecture, mutations and post-translational modifications.
Review
Porto Alegre, Brazil. In Mutat Res Rev Mutat Res, 2015
The xeroderma pigmentosum complementation group proteins (XPs), which include XPA through XPG, play a critical role in coordinating and promoting global genome and transcription-coupled nucleotide excision repair (GG-NER and TC-NER, respectively) pathways in eukaryotic cells.
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.
Impact
Baltimore, United States. In Cell, 2014
We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo.
Polymorphisms in DNA repair genes of XRCC1, XPA, XPC, XPD and associations with lung cancer risk in Chinese people.
Tianjin, China. In Thorac Cancer, 2014
RESULTS: In single tag SNP analysis, XPA rs2808668, XPC rs2733533, and XPD rs1799787 were significantly associated with lung cancer susceptibility.
Cadmium and cancer.
Review
Karlsruhe, Germany. In Met Ions Life Sci, 2012
Particularly sensitive targets appear to be proteins with zinc-binding structures, present in DNA repair proteins such as XPA, PARP-1 as well as in the tumor suppressor protein p53.
XPA A23G polymorphism and susceptibility to cancer: a meta-analysis.
GeneRIF
Jinan, China. In Mol Biol Rep, 2012
The XPA A23G G allele is a low-penetrant risk factor for cancer development. [Meta-analysis]
Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA.
GeneRIF
Lund, Sweden. In J Neurosurg, 2012
The authors' results suggest that lack of the DNA repair factor XPA may delay neurobehavioral recovery after TBI
HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer.
GeneRIF
Albuquerque, United States. In Carcinogenesis, 2012
studies identify HIF1alpha as a key protein in regulating transcription of XPA in lung cancer cell lines and primary tumors contributing to cisplatin resistance
Platelet-activating factor receptor agonists mediate xeroderma pigmentosum A photosensitivity.
GeneRIF
Indianapolis, United States. In J Biol Chem, 2012
Oxidized glycerophosphocholines play a pivotal role in the photosensitivity associated with the deficiency of XPA.
[The relationship between polymorphism of genes XPA, XPC, XPD, XRCC1 and susceptibility to acute lymphoblastic leukemia].
GeneRIF
Nanjing, China. In Zhonghua Nei Ke Za Zhi, 2011
XPA A23G and XPC C499T polymorphisms may contribute to the risk of developing acute lymphoblastic leukemia.
Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie.
Impact
Dresden, Germany. In J Clin Oncol, 2009
Polymorphisms within genes of TS, MTHFR, MTR, OPRT, XPD, ERCC1, XRCC1, XPA, GSTP1, GSTT1, and GSTM1 were genotyped using polymerase chain reaction-based techniques.
Premature aging in mice deficient in DNA repair and transcription.
Impact
Rotterdam, Netherlands. In Science, 2002
TTD mice carrying an additional mutation in XPA, which enhances the DNA repair defect, showed a greatly accelerated aging phenotype, which correlated with an increased cellular sensitivity to oxidative DNA damage.
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.
Impact
Bethesda, United States. In Nat Med, 2001
Xeroderma pigmentosum cells deficient in the NER genes XPG, XPA, XPD or XPF were resistant to Et743, and sensitivity was restored by complementation with wild-type genes.
Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA.
Impact
Los Angeles, United States. In Cell, 2000
We have shown that a globular domain at the C terminus of subunit RPA32 contains a specific surface that interacts in a similar manner with the DNA repair enzyme UNG2 and repair factors XPA and RAD52, each of which functions in a different repair pathway.
