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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Epithelial membrane protein 2

XMP, EMP2, epithelial membrane protein-2
Top mentioned proteins: ACID, IMPDH, STEP, CAN, V1a
Papers on XMP
New insight into the architecture of oxy-anion pocket in unliganded conformation of GAT domains: A MD-simulation study.
Bansal et al., Bengaluru, India. In Proteins, Feb 2016
UNASSIGNED: Human Guanine Monophosphate Synthetase (hGMPS) converts XMP to GMP, and acts as a bifunctional enzyme with N-terminal 'glutaaminase' (GAT) and C-terminal 'synthetase' domain.
GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.
Phillips et al., Dallas, United States. In Mol Microbiol, Sep 2015
The purine salvage pathway is redundant and contains two routes to guanosine-5'-monophosphate (GMP) formation: conversion from xanthosine-5'-monophosphate (XMP) by GMP synthase (GMPS) or direct salvage of guanine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT).
Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1.
Zhou et al., Nanjing, China. In J Am Soc Nephrol, Sep 2015
We previously identified mutations in epithelial membrane protein 2 (EMP2) as a monogenic cause of this disease.
Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer.
Mills et al., Oslo, Norway. In Oncotarget, Jun 2015
In this study, we report that in PCa cells de novo purine biosynthesis and the subsequent conversion to XMP is tightly regulated by MYC and independent of AR activity.
The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma.
Shiue et al., Tainan City, Taiwan. In Oncotarget, May 2015
In this study, we report that EMP2 plays a tumor suppressor role by inducing G2/M cell cycle arrest, suppressing cell viability, proliferation, colony formation/anchorage-independent cell growth via regulation of G2/M checkpoints in distinct urinary bladder urothelial carcinoma (UBUC)-derived cell lines.
A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.
Joachimiak et al., Chicago, United States. In J Biol Chem, Mar 2015
IMPDH catalyzes the oxidation of IMP to XMP with the concomitant reduction of NAD(+), which is the pivotal step in the biosynthesis of guanine nucleotides.
The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling.
Micke et al., Uppsala, Sweden. In Faseb J, 2014
Transcript levels of 10 genes (SFTPB, SFTPC, SFTPD, SLC34A2, LAMP3, CACNA2D2, AGER, EMP2, NKX2-1, and NAPSA) were significantly associated with survival in the adenocarcinoma subgroup, thus qualifying as promising biomarker candidates.
Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.
Joachimiak et al., Waltham, United States. In Plos One, 2014
The crystal structures of a deletion mutant of MtbIMPDH2 in the apo form and in complex with the product XMP and substrate NAD+ are determined.
Immunohistochemical expression of cytokeratins and epithelial membrane protein 2 in nasopharyngeal carcinoma and its potential implications.
Alshammari et al., Saudi Arabia. In Asian Pac J Cancer Prev, 2014
MATERIALS AND METHODS: One hundred and fifty tissue samples with NPC diagnosis were were investigated using pan cytokeratin (CK) and epithelial membrane protein 2 (EMP2) antibodies.
Achieving the CCSD(T) Basis-Set Limit in Sizable Molecular Clusters: Counterpoise Corrections for the Many-Body Expansion.
Herbert et al., Columbus, United States. In J Phys Chem Lett, 2013
A triples correction, ╬┤CCSD(T) = ECCSD(T) - EMP2, can be estimated accurately and efficiently as well.
(64)Cu-Labeled DOTA conjugated anti-epithelial membrane protein 2 minibody KS83
Chopra, Bethesda, United States. In Unknown Journal, 2013
Endometrial membrane protein-2 (EMP2) is a member of the growth-arrest specific protein 3/peripheral myelin protein 22 family of proteins, which are believed to play a role in the development of endometrial cancer in women (1).
Resolving differences in substrate specificities between human and parasite phosphoribosyltransferases via analysis of functional groups of substrates and receptors.
Antosiewicz et al., Warsaw, Poland. In Curr Pharm Des, 2012
Most interesting is the observation of a large conformational change, leading to tighter binding of the ligand, observed in constant-pH MD simulations of the parasite PRTase complexed with XMP, and lack of such a change in the human enzyme complexed with XMP.
Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.
Wadehra et al., Los Angeles, United States. In Plos One, 2010
Manipulation of EMP2 levels in endometrial cancer cells regulates the phosphorylation of FAK and Src, and promotes their distribution into lipid raft domains.
Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer.
Wadehra et al., Los Angeles, United States. In Clin Cancer Res, 2010
EMP2 is expressed in the majority of ovarian tumors and may be a feasible target in vivo.
Xanthosine 5'-monophosphate (XMP). Acid-base and metal ion-binding properties of a chameleon-like nucleotide.
Griesser et al., Basel, Switzerland. In Chem Soc Rev, 2009
The four acidity constants of threefold protonated xanthosine 5'-monophosphate, H(3)(XMP)(+), reveal that in the physiological pH range around 7.5 (X - H x MP)(3-) strongly dominates and not XMP(2-) as commonly given in textbooks and often applied in research papers.
Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines.
Wadehra et al., Los Angeles, United States. In Clin Cancer Res, 2008
EMP2 may be a potential pharmacologic target for human endometrial cancer.
Steroid hormone regulation of EMP2 expression and localization in the endometrium.
Braun et al., Los Angeles, United States. In Reprod Biol Endocrinol, 2007
Targeting of EMP2 to specific locations under the influence of these steroid hormones may be important for integrating the molecular responses required for implantation competence.
The tetraspan protein EMP2 regulates expression of caveolin-1.
Braun et al., Los Angeles, United States. In J Biol Chem, 2007
EMP2 regulates caveolin-1 transcription and more substantially its protein levels.
The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
Nimmesgern et al., Cambridge, United States. In Immunopharmacology, 2000
The enzymatic reaction of oxidation of IMP to XMP proceeds through a covalent mechanism involving an active site cysteine residue.
Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents.
Grifantini et al., Italy. In Curr Med Chem, 1999
IMP dehydrogenase (IMPDH) is an enzyme which catalyzes the NAD-dependent conversion of inosine 5 -monophosphate (IMP) to xanthosine 5 -monophosphate (XMP) at the metabolic branch point in the de novo purine nucleotide synthetic pathway.
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