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Discs, large homolog 3

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CAN, PSD-95, Mre11, HAD, Rad50
Papers on XLMR
Yeast MRX deletions have short chronological life span and more triacylglycerols.
Srinivasan et al., Mysore, India. In Fems Yeast Res, Feb 2016
Among these, RAD50, MRE11 and XRS2 form a complex, MRX that is involved in homologous recombination that showed an increase in the amount of TAG.
Structural and Biochemical Characterizations of Methanoredoxin from Methanosarcina acetivorans, a Glutaredoxin-Like Enzyme with Coenzyme M-Dependent Protein Disulfide Reductase Activity.
Ferry et al., United States. In Biochemistry, Feb 2016
We report here the biochemical and structural properties of a GRX-like protein named methanoredoxin (MRX) from Methanosarcina acetivorans of the domain Archaea.
S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.
Wang et al., Taipei, Taiwan. In Nucleic Acids Res, Feb 2016
The yeast and mammalian Mre11-Rad50-Xrs2/Nbs1 (MRX/N)-Sae2/Ctp1 complex catalyzes the resection of DSBs induced by secondary structures, chemical adducts or covalently-attached proteins.
Homozygous c.1160C>T (P38L) in the MECP2 gene in a female Rett syndrome patient.
Das et al., Mumbai, India. In J Clin Neurosci, Feb 2016
Moreover to our knowledge this mutation has only been reported in males with X-linked mental retardation (MRX).
Depolarization of Hippocampal Neurons Induces Formation of Nonsynaptic NMDA Receptor Islands Resembling Nascent Postsynaptic Densities(1,2,3).
Reese et al., Bethesda, United States. In Eneuro, Nov 2015
In contrast to mature PSDs, islands contain more NMDA than AMPA receptors, and more SAP102 than PSD-95, features that are shared with nascent PSDs in developing synapses.
[New antibacterial agents on the market and in the pipeline].
Kern, Freiburg, Germany. In Internist (berl), Nov 2015
New developments can also be observed among oxazolidinones (tedizolid, radezolid, cadazolid and MRX-I), macrolides/ketolides (modithromycin and solithromycin), aminoglycosides (plazomicin), quinolones (nemonoxacin, delafloxacin and avarofloxacin), tetracyclines (omadacycline and eravacycline) as well as among glycopeptides and lipopeptides (oritavancin, telavancin, dalbavancin and surotomycin).
mRNA metabolism and neuronal disease.
Gehring et al., Würzburg, Germany. In Febs Lett, Jul 2015
Here we discuss three prominent genetic diseases that fall into this category, namely spinal muscular atrophy (SMA), retinitis pigmentosa (RP) and X-linked syndromic mental retardation (XLMR).
Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks.
Cejka et al., Zürich, Switzerland. In Nature, 2014
Genetic evidence suggests that this process is initiated by the Mre11-Rad50-Xrs2 (MRX) complex.
New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile.
Yuan et al., Hayward, United States. In J Med Chem, 2014
This annotation describes a novel oxazolidinone agent, (S)-5-((isoxazol-3-ylamino)methyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one (MRX-I), distinguished by its high activity against Gram-positive pathogens coupled with markedly reduced potential for myelosuppression and MAOI.
X-linked mental deficiency.
des Portes, Lyon, France. In Handb Clin Neurol, 2012
X-linked mental retardation (XLMR) includes more than 200 syndromes and 80 genes identified to date.
Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration.
Zhang et al., Shanghai, China. In Cell, 2012
FGF13, a nonsecretory protein of the FGF family, is expressed in cerebral cortical neurons during development and is a candidate gene for syndromal and nonspecific forms of X-chromosome-linked mental retardation (XLMR).
Distribution of extrasynaptic NMDA receptors on neurons.
Petralia, Bethesda, United States. In Scientificworldjournal, 2011
Extrasynaptic NMDA receptor clusters vary in size and may form associations with scaffolding proteins such as PSD-95 and SAP102.
Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.
Lickert et al., München, Germany. In Dev Cell, 2011
Dlg3 exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 through its PPxY motifs. These interactions are required for Dlg3 monoubiquitination, apical membrane recruitment, and tight junction consolidation.
Polymorphisms in the DLG3 gene is not associated with non-syndromic mental retardation in the Chinese Han population of Qin-Ba mountain.
Zhang et al., Taiwan. In Cell Mol Neurobiol, 2011
DLG3 did not associate with non-syndromic mental retardation in Chinese Han population; however, further studies are needed.
Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD).
Järvelä et al., Helsinki, Finland. In Autism Res, 2011
A total of six novel and 11 known single nucleotide polymorphisms were identified. Further studies are warranted to analyze the candidate genes at Xq11.1-q21.33.
Comprehensive evaluation of the contribution of X chromosome genes to platinum sensitivity.
Huang et al., Chicago, United States. In Mol Cancer Ther, 2011
DLG3 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin. DLG3 was also found to correlate with cellular sensitivity to platinating agents in NCI-60 cancer cell lines.
NMDA receptor-dependent regulation of dendritic spine morphology by SAP102 splice variants.
Roche et al., Bethesda, United States. In J Neurosci, 2011
The data of this study provided the first evidence that SAP102 links NMDA receptor activation to alterations in spine morphology.
DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.
Kowalczykowski et al., Davis, United States. In Nature, 2010
In addition to this core machinery, we establish that both the topoisomerase 3 (Top3) and Rmi1 complex and the Mre11-Rad50-Xrs2 complex (MRX) have important roles as stimulatory components.
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.
Sung et al., New Haven, United States. In Nature, 2010
Being guided by recent genetic studies, we have reconstituted the first eukaryotic ATP-dependent DNA end-resection machinery comprising the Saccharomyces cerevisiae Mre11-Rad50-Xrs2 (MRX) complex, the Sgs1-Top3-Rmi1 complex, Dna2 protein and the heterotrimeric ssDNA-binding protein RPA.
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.
Shi et al., Boston, United States. In Nature, 2010
X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability.
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