GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Hepatitis B virus x interacting protein
XIP, HBXIP, HBX-interacting protein
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008] (from
NCBI)
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CAN, ACID, V1a, HAD, HOX11L1
Papers on
XIP
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.
New
Tianjin, China. In Cancer Res, Feb 2016
Among 388 c-Myc target genes in human MCF-7 breast cancer cells, we found that their promoters could be occupied by the oncoprotein HBXIP.
Hepatitis B virus X protein binding to hepsin promotes C3 production by inducing IL-6 secretion from hepatocytes.
New
Shanghai, China. In Oncotarget, Feb 2016
In this study, we identified hepsin as an HBx-interacting protein and investigated the effects of hepsin on HBx-mediated complement component 3 (C3) secretion in hepatocytes.
Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion.
New
Changsha, China. In Mol Neurobiol, Feb 2016
Additionally, IMM-H004 also enhanced the expression of hepatitis B X-interacting protein (HBXIP), which formed a complex with survivin to prevent the activation of caspase death cascade, thereby halting apoptotic cell death.
Interaction of the hepatitis B virus X protein with the lysine methyltransferase SET and MYND domain-containing 3 induces activator protein 1 activation.
New
Kōbe, Japan. In Microbiol Immunol, Jan 2016
In conclusion, a novel HBx-interacting protein, SMYD3, was identified, leading to proposal of a novel mechanism of AP-1 activation in HBV-infected cells.
Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.
New
Tianjin, China. In Oncogene, Jan 2016
In this study, we explored the hypothesis that the oncoprotein hepatitis B X-interacting protein (HBXIP) is involved in the reduction of MST1 in breast cancer.
MicroRNA-548p suppresses hepatitis B virus X protein associated hepatocellular carcinoma by downregulating oncoprotein HBXIP.
New
Guangzhou, China. In Hepatol Res, Dec 2015
MiR-548p directly downregulated the expression of hepatitis B x-interacting protein (HBXIP) by binding to the 3'UTR of HBXIP mRNA.
Fusarium graminearum produces different xylanases causing host cell death that is prevented by the xylanase inhibitors XIP-I and TAXI-III in wheat.
New
Viterbo, Italy. In Plant Sci, Nov 2015
Subsequently, we demonstrated that TAXI-III and XIP-I prevented both the enzyme and host cell death activities of F. graminearum xylanases.
Bidirectional signaling in the competence regulatory pathway of Streptococcus mutans.
New
Gainesville, United States. In Fems Microbiol Lett, Oct 2015
Streptococcus mutans expresses comX (also known as sigX), which encodes a sigma factor that is required for development of genetic competence, in response to the peptide signals XIP and CSP and environmental factors.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
New
Tianjin, China. In Oncotarget, Oct 2015
The oncoprotein hepatitis B X-interacting protein (HBXIP) functions in the development of breast cancer.
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Impact
GeneRIF
Cambridge, United States. In Cell, 2012
Study identified HBXIP and C7orf59 as two additional Ragulator components that are required for mTORC1 activation by amino acids.
The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.
GeneRIF
Tianjin, China. In J Biol Chem, 2012
HBXIP up-regulates S100A4 through activating S100A4 promoter involving STAT4 and inducing PTEN/PI3K/AKT signaling to promote growth and migration of breast cancer cells.
Overexpression of hepatitis B x-interacting protein in HepG2 cells enhances tumor-induced angiogenesis.
GeneRIF
Zhengzhou, China. In Mol Cell Biochem, 2012
overexpression of HBXIP increased HepG2 cell-induced endothelial cells migration, proliferation, and angiogenesis, which may be related to increasing phosphorylation of endothelial NO synthase in HUVECs.
HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack.
GeneRIF
Tianjin, China. In Febs Lett, 2012
Data suggest that HBXIP upregulates CD46, CD55 and CD59 through p-ERK1/2/NF-kappaB signaling to protect breast cancer from complement-dependent cytotoxicity.
[The different structure forms of HBx protein influence their intracellular distribution in hepatocellular carcinoma HepG2 cells].
GeneRIF
Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
The different structure forms of HBx protein influence their intracellular distribution in hepatocellular carcinoma HepG2 cells
Proteinaceous inhibitors of microbial xylanases.
Review
Moscow, Russia. In Biochemistry (mosc), 2010
aestivum xylanase inhibitor) and XIP (xylanase-inhibiting protein).
Enzyme-inhibitor interactions at the plant-pathogen interface.
Review
Köln, Germany. In Curr Opin Plant Biol, 2008
Examples are pathogen xylanases and polygalacturonases that are inhibited by plant proteins like TAXI, XIP, and PGIP; and plant glucanases and proteases, which are targeted by pathogen proteins such as GIP1, EPI1, EPIC2B, and AVR2.
ncx1, ncx2, and ncx3 gene product expression and function in neuronal anoxia and brain ischemia.
Review
Napoli, Italy. In Ann N Y Acad Sci, 2007
We explored the consequences of the pharmacological inhibition of this antiporter with conventional pharmacological approach, with the synthetic inhibitory peptide, XIP, or with an antisense strategy on the extent of brain damage induced by the permanent occlusion of middle cerebral artery (pMCAO) in rats.
Microbial endoxylanases: effective weapons to breach the plant cell-wall barrier or, rather, triggers of plant defense systems?
Review
Leuven, Belgium. In Mol Plant Microbe Interact, 2006
Furthermore, the role of the relatively recently discovered cereal endoxylanase inhibitor families TAXI (Triticum aestivum xylanase inhibitor) and XIP (xylanase inhibitor protein) in plant defense is discussed.
An IAP in action: the multiple roles of survivin in differentiation, immunity and malignancy.
Review
Zürich, Switzerland. In Cell Cycle, 2004
In the cytoplasm, survivin inhibits apoptosis by interacting with caspase-9 in the presence of the HBXIP cofactor, by binding to Smac or associating with XIAP.
