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Xanthine dehydrogenase

xanthine oxidase, xanthine dehydrogenase
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, Ros, V1a, SOD
Papers on xanthine oxidase
Unorthodox methods for enhancing solvent production in solventogenic Clostridium species.
Ezeji et al., Wooster, United States. In Appl Microbiol Biotechnol, Feb 2016
In this review, the impacts of metabolic perturbations including medium supplementation with glycerol; furfural and 5-hydroxymethyl furfural; allopurinol, an inhibitor of xanthine dehydrogenase; calcium (Ca(2+)) and zinc (Zn(2+)) ions); and artificial electron carriers, methyl viologen and neutral red, on butanol production are discussed.
Biological Activities of Uric Acid in Infection due to Enteropathogenic and Shiga-toxigenic Escherichia coli.
Lis et al., Buffalo, United States. In Infect Immun, Feb 2016
UNASSIGNED: In previous work we identified xanthine oxidase (XO) as an important enzyme in the interaction between the host and enteropathogenic and Shiga-toxigenic E. coli (EPEC and STEC).
Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action.
Saúde-Guimarães et al., Ouro Preto, Brazil. In J Ethnopharmacol, Feb 2016
MATERIALS AND METHODS: Anti-hyperuricemic effect was investigated using xanthine oxidase assay and uricosuric studies with rats in which hyperuricemia was induced by potassium oxonate and uric acid.
Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications.
Kagan et al., Pittsburgh, United States. In Toxicol Appl Pharmacol, Feb 2016
Here, we review the role and contribution of different oxidative enzymes of inflammatory cells - myeloperoxidase, eosinophil peroxidase, lactoperoxidase, hemoglobin, and xanthine oxidase - to the reactions of nanoparticle biodegradation.
Molybdenum cofactor deficiency.
Scaglia et al., Houston, United States. In Mol Genet Metab, Jan 2016
MoCD results in deficiency of the molybdenum cofactor dependent enzymes sulfite oxidase, xanthine dehydrogenase, aldehyde oxidase and mitochondrial amidoxime reducing component.
Oral Zinc Supplementation Restores Superoxide Radical Scavengers to Normal Levels in Spermatozoa of Iraqi Asthenospermic Patients.
Alsalman et al., Arāk, Iran. In Int J Vitam Nutr Res, Dec 2015
The present study was conducted to examine the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with oxido-sensitive index level (superoxide dismutase/xanthine oxidase ratio) in the seminal plasma of asthenospermic patients.
Oxidative stress and myocarditis.
Suzuki et al., Tokyo, Japan. In Curr Pharm Des, Dec 2015
ROS are produced by mitochondrial respiratory chain reactions and enzymes including NADPH oxidases, cyclooxygenase, and xanthine oxidase.
Reperfusion injury and reactive oxygen species: The evolution of a concept.
Kvietys et al., Shreveport, United States. In Redox Biol, Dec 2015
Of the potential ROS sources described to date, xanthine oxidase, NADPH oxidase (Nox), mitochondria, and uncoupled nitric oxide synthase have gained a status as the most likely contributors to reperfusion-induced oxidative stress and represent priority targets for therapeutic intervention against reperfusion-induced organ dysfunction and tissue damage.
Effects of 12-Week Endurance Training at Natural Low Altitude on the Blood Redox Homeostasis of Professional Adolescent Athletes: A Quasi-Experimental Field Trial.
Nie et al., Hong Kong, Hong Kong. In Oxid Med Cell Longev, Dec 2015
Following the conditioning program, unaltered serum levels of thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (T-AOC), and superoxide dismutase accompanied with an increase in oxidized glutathione (GSSG) and decreases of xanthine oxidase, reduced glutathione (GSH), and GSH/GSSG ratio were observed in both Alt and SL groups.
Chemical Composition and Antioxidant Properties of Juniper Berry (Juniperus communis L.) Essential Oil. Action of the Essential Oil on the Antioxidant Protection of Saccharomyces cerevisiae Model Organism.
Krastanov et al., Vienna, Austria. In Antioxidants (basel), 2013
The antioxidant capacity of the essential oil was evaluated in vitro by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging, 2,2-azino-bis-3-ethylbenzothiazoline-6 sulfonic acid (ABTS) radical cation scavenging, hydroxyl radical (ОН(•)) scavenging and chelating capacity, superoxide radical ((•)O₂(-)) scavenging and xanthine oxidase inhibitory effects, hydrogen peroxide scavenging.
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.
Nussenzweig et al., New York City, United States. In Nat Med, 2013
We found that type I IFN supports the upregulation of xanthine dehydrogenase, which metabolizes the xanthine accumulating in infected erythrocytes to uric acid.
Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta.
Permezel et al., Melbourne, Australia. In J Endocrinol, 2012
XO significantly decreases glucose transporter GLUT1 gene and protein expression and resultant glucose uptake in the placenta.
Assessment of paraoxonase 1, xanthine oxidase and glutathione peroxidase activities, nitric oxide and thiol levels in women with polycystic ovary syndrome.
Kaya et al., Kayseri, Turkey. In Acta Obstet Gynecol Scand, 2012
Serum XO activities were higher in women with polycystic ovary syndrome than in the control women (p<0.001).
Decreased xanthine oxidoreductase (XOR) is associated with a worse prognosis in patients with serous ovarian carcinoma.
Lundin et al., Helsinki, Finland. In Gynecol Oncol, 2012
Decreased XOR is associated with poorer prognosis in patients with serous ovarian cancer.
Novel mutations in xanthine dehydrogenase/oxidase cause severe hypouricemia: biochemical and molecular genetic analysis in two Czech families with xanthinuria type I.
Sebesta et al., Praha, Czech Republic. In Clin Chim Acta, 2012
xanthine oxidase activities in patients were 0 and 0.4 pmol/h/mL of plasma. We found three nonsense changes: p.P214QfsX4 and unpublished p.R825X and p.R881X
Gout therapeutics: new drugs for an old disease.
Wortmann et al., United States. In Lancet, 2011
The approval of febuxostat, a non-purine-analogue inhibitor of xanthine oxidase, by the European Medicines Agency and the US Food and Drug Administration heralds a new era in the treatment of gout.
Determination of oxygen derived free radicals producer (xanthine oxidase) and scavenger (paraoxonase1) enzymes and lipid parameters in different cancer patients.
Athar et al., Lahore, Pakistan. In Clin Lab, 2010
Lower PON1 and high xanthine oxidase enzyme activities cause an imbalance of the free radical system.
Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial.
Struthers et al., Dundee, United Kingdom. In Lancet, 2010
BACKGROUND: Experimental evidence suggests that xanthine oxidase inhibitors can reduce myocardial oxygen consumption for a particular stroke volume.
Molybdenum cofactor biosynthesis and molybdenum enzymes.
Mendel et al., Braunschweig, Germany. In Annu Rev Plant Biol, 2005
(3) Aldehyde oxidase catalyzes the last step of abscisic acid biosynthesis, and (4) xanthine dehydrogenase is essential for purine degradation and stress response.
Singlet molecular oxygen from superoxide anion and sensitized fluorescence of organic molecules.
Khan, In Science, 1970
Recent identification of O(2)- in the xanthine oxidase system suggests that the generation of singlet oxygen may also occur in enzymatic systems.
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