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X antigen family, member 1D

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: HAD, Phosphogluconate Dehydrogenase, NY-ESO-1, POLYMERASE, AGE
Papers on XAGE-1
Local and systemic XAGE-1b-specific immunity in patients with lung adenocarcinoma.
van der Burg et al., Leiden, Netherlands. In Cancer Immunol Immunother, Sep 2015
XAGE-1b is a cancer/testis antigen aberrantly expressed in pulmonary adenocarcinoma.
Prospective validation of a new method of monitoring minimal residual disease in childhood acute myelogenous leukemia.
Gruhn et al., Ulm, Germany. In Clin Cancer Res, Apr 2015
EXPERIMENTAL DESIGN: The expression of seven leukemia-associated genes (WT1, PRAME, CCL23, GAGED2, MSLN, SPAG6, and ST18) was measured by TaqMan Low Density Arrays in 112 patients and 52 healthy controls.
XAGE-1b cancer/testis antigen is a potential target for immunotherapy in prostate cancer.
Wang et al., Shanghai, China. In Urol Int, 2014
XAGE-1b is a member of the cancer/testis antigen family which has demonstrated strong immunogenicity.
XAGE-1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma.
Zhou et al., Shanghai, China. In Mol Clin Oncol, 2014
XAGE-1b is a 470 bp transcript of the XAGE-1 gene, which belongs to the cancer-testis antigens that exhibit a restricted pattern of expression in normal tissues.
Genetic variants of immunoglobulin γ and κ chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer.
Nakayama et al., Charleston, United States. In Clin Exp Immunol, 2014
In this study, we aimed to determine whether particular GM and KM (κ marker) allotypes were associated with antibody responsiveness to XAGE-1b, a highly immunogenic lung tumour-associated cancer-testis antigen.
Promoting effects on the proliferation and metastasis of ACC tumor cell with XAGE-1b overexpression.
Zhu et al., Nanjing, China. In Oncol Rep, 2013
There is no clear role established for XAGE-1b, which is a member of the cancer testis antigen family in tumorigenesis and the metastasis process of ACC.
Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth.
Zhu et al., Nanjing, China. In Biomed Rep, 2013
The XAGE-1b gene has been identified in numerous malignancies in the human body.
A cancer/testis antigen microarray to screen autoantibody biomarkers of non-small cell lung cancer.
Liu et al., Beijing, China. In Cancer Lett, 2013
The CTA panel of NY-ESO-1, XAGE-1, ADAM29 and MAGEC1, had sensitivity and specificity values of 33% and 96%, respectively.
Spontaneous antibody, and CD4 and CD8 T-cell responses against XAGE-1b (GAGED2a) in non-small cell lung cancer patients.
Nakayama et al., Kurashiki, Japan. In Int J Cancer, 2012
The spontaneous immune responses against XAGE-1b (GAGED2a) were analyzed in non-small cell lung cancer (NSCLC) patients.
XAGE-1a and XAGE-1d are potential biomarkers of lung squamous cell carcinoma.
Park et al., Taejŏn, South Korea. In Clin Chim Acta, 2012
We evaluated the diagnostic potential of sera XAGE-1a and XAGE-1d in lung cancer, both of which are variants of the X antigen family, member 1. METHODS: The expression levels of XAGE-1a and XAGE-1d in cell lines were determined using western blot analysis.
Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage.
Karpf et al., Buffalo, United States. In Clin Cancer Res, 2011
EXPERIMENTAL DESIGN: We used quantitative mRNA expression and DNA methylation analyses to determine the relationship between expression and methylation of X-linked (MAGE-A1, NY-ESO-1, XAGE-1) and autosomal (BORIS, SOHLH2) CG genes, global DNA methylation (5mdC levels, LINE-1, Alu, and Sat-α methylation), and clinicopathology, using 75 EOC samples.
NLS-dependent and insufficient nuclear localization of XAGE-1 splice variants.
Zhu et al., Shanghai, China. In Oncol Rep, 2011
Four transcript variants XAGE-1a, -1b, -1c and XAGE-1d have been discovered and have a broad expression in cancer.
A novel multiplex assay combining autoantibodies plus PSA has potential implications for classification of prostate cancer from non-malignant cases.
Zeng et al., Los Angeles, United States. In J Transl Med, 2010
Peptide epitopes from cancer/testis antigen NY-ESO-1, XAGE-1b, SSX-2,4, as well as prostate cancer overexpressed antigen AMACR, p90 autoantigen, and LEDGF were then conjugated with seroMAP microspheres to allow multiplex measurement of autoAb present in serum samples.
Hepatocellular carcinoma patients highly and specifically expressing XAGE-1 exhibit prolonged survival.
Leng et al., Beijing, China. In Oncol Lett, 2010
XAGE-1 is classified into the group of a new family of cancer-testis antigens (CTA) and has the four transcript variants of XAGE-1a, XAGE-1b, XAGE-1c and XAGE-1d.
[Association of XAGE-1 gene expression with clinical characteristics of lung cancer].
Sun et al., Zaozhuang, China. In Zhongguo Fei Ai Za Zhi, 2010
XAGE-1 gene is highly expressed in lung adenocarcinoma.
Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens.
Nishimura et al., Sapporo, Japan. In Cancer Immun, 2007
The findings suggest that XAGE-1b and HLA class I expression elicited a CD8+ T-cell response against minimal residual disease after surgery and resulted in prolonged survival of non-small cell lung cancer patients.
[Association of XAGE-1b gene expression with clinical characteristics of non-small cell lung cancer].
Wu et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2007
XAGE-1b gene is highly expressed in lung adenocarcinoma.
Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors.
Nakayama et al., Okayama, Japan. In Cancer Immun, 2006
XAGE-1b is a promising target molecule for a cancer vaccine against lung cancer.
HLA-DRB1*0410-restricted recognition of XAGE-1b37-48 peptide by CD4 T cells.
Nakayama et al., Okayama, Japan. In Microbiol Immunol, 2006
A 12-mer peptide XAGE-1b(37-48) as a new XAGE-1b epitope restricted to HLA-DRB1*0410 was identified.
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