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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Interleukin 27 receptor, alpha

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: P28, IL-12, NMDA receptor, IFN-gamma, Interleukin-6
Papers on WSX-1
Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.
Arbour et al., Montréal, Canada. In Glia, Jan 2016
The expression of IL-27 subunits (EBI3 and p28) and its cognate receptor IL-27R (the gp130 and TCCR chains) was elevated within post-mortem MS brain lesions compared with normal control brains.
Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.
Jones et al., Cardiff, United Kingdom. In J Exp Med, Nov 2015
The presence of synovial ELS was also noted in mice deficient in the IL-27 receptor (IL-27R) after the onset of inflammatory arthritis.
The biology of interleukin-27 reveals unique pro- and anti-inflammatory functions in immunity.
Garbers et al., Kiel, Germany. In Cytokine Growth Factor Rev, Oct 2015
EBI3 functions as a soluble α-receptor, and IL-27 can therefore directly activate its target cells through a heterodimer of glycoprotein 130 (gp130) and WSX-1.
[Effects of interleukin 27 and its receptor on TGFβinduced murine pulmonary fibroblast proliferation and transformation].
Zhang et al., Kunming, China. In Nan Fang Yi Ke Da Xue Xue Bao, Oct 2015
OBJECTIVE: To investigate the effects of interleukin-27 (IL-27) and its receptor (WSX-1) on the proliferation, transformation and collagen synthesis of the mouse lung fibroblasts.
Potential clinical application of interleukin-27 as an antitumor agent.
Mizoguchi et al., Tokyo, Japan. In Cancer Sci, Sep 2015
However, the endogenous role of IL-27 subunits and one of its receptor subunits, WSX-1, in the susceptibility to tumor development after transplantation of tumor cell lines or endogenously arising tumors seems to be more complicated.
Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
Cooper et al., Shenzhen, China. In J Exp Med, Sep 2015
IL-27 is highly expressed during human tuberculosis (TB), and absence of IL-27R (Il27ra) specifically on T cells results in increased protection.
Interleukin-27 Protects Cardiomyocyte-Like H9c2 Cells against Metabolic Syndrome: Role of STAT3 Signaling.
Ma et al., Taipei, Taiwan. In Biomed Res Int, 2014
The mRNA of glycoprotein (gp) 130 and WSX-1, both components of the interleukin (IL)-27 receptor, were present in H9c2 cells.
Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection.
Zuniga et al., San Diego, United States. In Immunity, 2013
Furthermore, IL-27R was critical for control of persistent LCMV in vivo.
TCCR/WSX-1 is a novel angiogenic factor in age-related macular degeneration.
Heo et al., South Korea. In Mol Vis, 2011
TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration.
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.
Reuther et al., Tampa, United States. In Biochem J, 2011
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.
The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses.
Kitching et al., Australia. In Am J Pathol, 2011
In Th1-dependent autoinflammatory lesions, IL-27Ralpha has a biphasic role in vivo, initially pathogenic, but ultimately playing a protective role by regulating immune responses and attenuating disease.
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.
Ghilardi et al., Sydney, Australia. In J Exp Med, 2011
Data show that the deletion of Il27ra ameliorates pathology in the pristane-induced SLE model.
Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.
Couper et al., London, United Kingdom. In J Immunol, 2010
Findings demonstrate the essential role of IL-27R signaling in regulating effector T cell function during malaria infection and reveal a novel pathway that might be amenable to manipulation by drugs or vaccines.
Humanin and the receptors for humanin.
Hashimoto et al., Tokyo, Japan. In Mol Neurobiol, 2010
Most recently, it has been shown that Humanin inhibits neuronal cell death and dysfunction by binding to a novel IL-6-receptor-related receptor(s) on the cell surface involving CNTFRalpha, WSX-1, and gp130.
[Immune regulation by IL-27 for therapeutic usage].
Yoshida, Saga, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2009
In the absence of IL-27-mediated immunosuppression, hyper-production of various pro-inflammatory cytokines concomitant with severe inflammation in affected organs was observed in IL-27 receptor alpha chain (WSX-1)-deficient mice infected with Trypanosoma cruzi.
Interleukin-35: odd one out or part of the family?
Vignali et al., Memphis, United States. In Immunol Rev, 2008
All four are heterodimeric cytokines, composed of an alpha chain (p19, p28, or p35) and a beta chain (p40 or Ebi3), and signal through unique pairings of five receptor chains (IL-12Rbeta1, IL-12Rbeta2, IL-23R, gp130, and WSX-1).
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.
Ghilardi et al., San Francisco, United States. In Nat Immunol, 2006
However, subsequent work has demonstrated that mice deficient in IL-27 receptor (IL-27R alpha) show exacerbated inflammatory responses to a variety of challenges, suggesting that IL-27 has important immunoregulatory functions in vivo.
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.
Yoshida et al., Fukuoka, Japan. In Immunity, 2003
WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors and is essential for resistance to Leishmania major infection.
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.
Hunter et al., Philadelphia, United States. In Immunity, 2003
Although recent studies have described IL-27 and its receptor, WSX-1, as promoters of Th1 differentiation in naive CD4+ T cells, the data presented here indicate that signaling through this receptor is involved in limiting the intensity and duration of T cell activity.
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.
Kastelein et al., Palo Alto, United States. In Immunity, 2002
a new heterodimeric cytokine that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide (IL-27)
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