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WD repeat and SOCS box containing 1

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, CIs, V1a, ACID
Papers on WSB1
Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells.
Yang et al., Hangzhou, China. In Cancer Res, Dec 2015
In this study, we define an integrative role for the E3 ubiquitin ligase subunit WSB1.
WSB1 promotes tumor metastasis by inducing pVHL degradation.
Lou et al., Rochester, United States. In Genes Dev, Dec 2015
Here we show that WD repeat and SOCS box-containing protein 1 (WSB1) is a negative regulator of pVHL through WSB1's E3 ligase activity.
Identification of Target Genes Regulated by KSHV miRNAs in KSHV-Infected Lymphoma Cells.
Tao et al., Shenyang, China. In Pathol Oncol Res, Sep 2015
Totally, 7 KSHV-related genes regulated by KSHV miRNAs were identified, including IPO5, EDA, NT5C3, WSB1, KCNS1, PRAM1 and MTRNR2L6.
Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.
Bianco et al., In J Clin Invest, Feb 2015
In the hypothalamus-pituitary dyad as well as the rest of the brain, the majority of T3 present is generated locally by T4 deiodination via the type 2 deiodinase (D2); this pathway is self-limited by ubiquitination of D2 by the ubiquitin ligase WSB-1.
Multiplex Ligation-dependent Probe Amplification Can Clarify HER2 Status in Gastric Cancers with "Polysomy 17".
Hsieh et al., Toronto, Canada. In J Cancer, 2014
Overall, 9 of 13 polyCEP17 cases had amplification of the peri-centromeric gene WSB1, compared to 1 of 8 non-polyCEP17 controls (p=0.02).
Minimal requirements for ubiquitination-mediated regulation of thyroid hormone activation.
Gereben et al., Budapest, Hungary. In J Mol Endocrinol, 2014
Fluorescence resonance energy transfer measurements demonstrated that the C-terminal globular domain of the ER-directed chimera was able to interact with the E3 ligase subunit WSB1.
Potential role of WSB1 isoforms in growth and survival of neuroblastoma cells.
Avigad et al., Petah Tikva, Israel. In Pediatr Res, 2014
BACKGROUND: WD repeat and SOCS box containing protein 1 (WSB1) generates three isoforms that were found to play a role in cancer cell growth and tumor progression.
HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells.
Xia et al., Shanghai, China. In Febs Lett, 2013
WSB-1 is involved in DNA damage response by targeting homeodomain-interacting protein kinase 2 (HIPK2) for ubiquitination and degradation.
Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.
Bianco et al., Miami, United States. In Biochim Biophys Acta, 2013
Notably, ubiquitination is a major step in the control of D2 activity, whereby T4 binding to and/or T4 catalysis triggers D2 inactivation by ubiquitination that is mediated by the E3 ubiquitin ligases WSB-1 and/or TEB4.
Type 2 deiodinase at the crossroads of thyroid hormone action.
Bianco et al., Miami, United States. In Int J Biochem Cell Biol, 2011
The hedgehog-inducible WSB-1 and the yeast Doa10 mammalian ortholog TEB4 are two E3 ligases that inactivate D2 via ubiquitination.
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
Lipton et al., Seoul, South Korea. In Blood, 2011
Candidate genes in those regions include RMND1, AKAP12, ZBTB2, and WSB1.
WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor.
Asao et al., Yamagata, Japan. In Cell Immunol, 2010
We identified a novel IL-21R-binding molecule, WSB-1, which contains WD-40 repeats and a SOCS-box domain.
Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1.
Choi et al., Suwŏn, South Korea. In J Biol Chem, 2008
the regulatory mechanisms by which HIPK2 is maintained at a low level, by WSB-1 in cells under normal conditions, and stabilized by genotoxic stresses.
The WSB1 gene is involved in pancreatic cancer progression.
Iovanna et al., Marseille, France. In Plos One, 2007
Data on WSB1 regulation support the hypothesis that activation of stress-response mechanisms helps cancer cells establishing metastases and suggest relevance to cancer development of other genes overexpressed in xenografts
Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
Gereben et al., Budapest, Hungary. In Endocrinology, 2007
Correlation between relative mRNA levels of WSB-1 and USP-33 in numerous tissues that do not express type 2 deiodinase(D2) suggests that these ubiquitin-related enzymes share additional substrates besides D2.
Raising the curtains on interchromosomal interactions.
Osborne et al., Cambridge, United Kingdom. In Trends Genet, 2006
By introducing an adaptation of this technique, Ling and colleagues have identified an unexpected coassociation between two loci on separate chromosomes in mouse nuclei, the imprinted Igf2-H19 locus of chromosome 7 and the Wsb1-Nf1 locus of chromosome 11.
Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma.
Khan et al., Gaithersburg, United States. In Genes Chromosomes Cancer, 2006
WSB1 shows strong correlations between expression level and copy number, and also enhances the prognostic prediction when combined with other current prognostic factors in neuroblastoma.
CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1.
Hoffman et al., Palo Alto, United States. In Science, 2006
Using a modification of chromosome conformation capture (3C) and fluorescence in situ hybridization, we found that one allele of the insulin-like growth factor 2 (Igf2)/H19 imprinting control region (ICR) on chromosome 7 colocalized with one allele of Wsb1/Nf1 on chromosome 11.
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Bianco et al., Boston, United States. In Nat Cell Biol, 2005
WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2).
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