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Tryptophan rich basic protein

Wrb, CHD5, CHD6
This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: Histone, CAN, Chordin, Glycophorin, ATPase
Papers on Wrb
Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.
Kehlenbach et al., Göttingen, Germany. In J Cell Sci, Jan 2016
Dominant negative fragments of the TRC40-receptor proteins WRB and CAML inhibited membrane insertion.
Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing.
Cai et al., Shenzhen, China. In Oncotarget, Dec 2015
We uncovered that MLL, EP400, PRDM2, ANK3 and CHD5 exclusively altered in recurrent BCs.
The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors.
Corey et al., Boston, United States. In J Physiol, Dec 2015
The pwi gene encodes a homolog of the yeast Get1 and human WRB proteins, which are receptors for membrane insertion of tail-anchored (TA) proteins.
Influence of colorectal cancer tumor suppressor gene CHD5 methylation on its clinical and pathological characteristics.
Yuan et al., Zhengzhou, China. In J Biol Regul Homeost Agents, Oct 2015
This study aimed to explore the influence of CHD5 methylation of CRC TSG on its clinical and pathological characteristics.
Mutational dynamics between primary and relapse neuroblastomas.
Schulte et al., Essen, Germany. In Nat Genet, Aug 2015
Recurrent alterations at relapse included mutations in the putative CHD5 neuroblastoma tumor suppressor, chromosome 9p losses, DOCK8 mutations, inactivating mutations in PTPN14 and a relapse-specific activity pattern for the PTPN14 target YAP.
The emerging role of calcium-modulating cyclophilin ligand in posttranslational insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
Sakisaka et al., Kōbe, Japan. In J Biochem, Jun 2015
While mammalian cells employ TRC40 and WRB, mammalian homologs of Get3 and Get1, respectively, they lack the gene homologous to Get2.
Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics.
Vermeulen et al., Nijmegen, Netherlands. In Febs J, May 2015
STRUCTURED DIGITAL ABSTRACT: MBD3 physically interacts with ZNF512B, HDAC1, ZMYND8, GATAD2B, SALL4, GATAD2A, ZNF592, MTA3, ZNF687, CDK2AP1, CHD3, ZNF532, HDAC2, MTA2, CHD4, MTA1, KPNA2, CHD5, RBBP4 and RBBP7 by pull down (View interaction) CDK2AP1 physically interacts with MBD3, MTA3, HDAC2, GATAD2A, CHD4, CDK2AP1, MTA2, HDAC1, MTA1, CHD3, GATAD2B, MBD2, RBBP4 and RBBP7 by pull down (View interaction) MBD3 physically interacts with MTA2, MTA3, RBBP4, RBBP7, HDAC2, HDAC1, CHD4, CHD3 and MTA1 by cross-linking study (View interaction).
Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors.
Lusser et al., Innsbruck, Austria. In Front Behav Neurosci, 2014
Using this model along with genetically related but fear extinction-competent 129S6/SvEv (S6) mice as controls, we found that impaired fear extinction in S1 was associated with enhanced ventral hippocampal expression of CHD1 and reduced expression of CHD5 that was normalized following successful rescue of impaired fear extinction.
The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.
Denic et al., Cambridge, United States. In Nature, 2014
The Get3 endoplasmic-reticulum receptor comprises the cytosolic domains of the Get1/2 (WRB/CAML) transmembrane complex, which interact individually with the targeting factor to drive a conformational change that enables substrate release and, as a consequence, insertion.
Role of CHD5 in human cancers: 10 years later.
Brodeur et al., Philadelphia, United States. In Cancer Res, 2014
CHD5 was first identified because of its location on 1p36 in a region of frequent deletion in neuroblastomas.
CHD chromatin remodelling enzymes and the DNA damage response.
Goodarzi et al., Calgary, Canada. In Mutat Res, 2013
We will first touch upon all four major chromatin remodelling enzyme families and then focus chiefly on the nine members of the Chromodomain, Helicase, DNA-binding (CHD) family, particularly CHD3, CHD4, CHD5 and CHD6.
1p36 tumor suppression--a matter of dosage?
Westermann et al., Heidelberg, Germany. In Cancer Res, 2013
We discuss recent data derived from both human tumors and functional cancer models indicating that the 1p36 genes CHD5, CAMTA1, KIF1B, CASZ1, and miR-34a contribute to cancer development when reduced in dosage by genomic copy number loss or other mechanisms.
CHD5, a tumor suppressor that is epigenetically silenced in lung cancer.
Ma et al., Guangzhou, China. In Lung Cancer, 2012
CHD5 is a potential tumor suppressor gene that is inactivated via an epigenetic mechanism in lung cancer.
A three-gene expression signature model for risk stratification of patients with neuroblastoma.
Lavarino et al., Barcelona, Spain. In Clin Cancer Res, 2012
Studies identified three genes, CHD5, PAFAH1B1, and NME1, strongly associated with patient outcome.
Mechanisms of CHD5 Inactivation in neuroblastomas.
Brodeur et al., Philadelphia, United States. In Clin Cancer Res, 2012
We conclude that (i) somatically acquired CHD5 mutations are rare in primary NBs, so inactivation probably occurs by deletion and epigenetic silencing.
MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5.
Gu et al., Beijing, China. In Plos One, 2011
the association of between miR-211-regulated CHD5 expression and CHD5 function in colorectal tumorigenesis
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.
Cai et al., Shenzhen, China. In Nat Genet, 2011
Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC.
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
Pazin et al., Baltimore, United States. In Plos One, 2010
CHD5 regulates expression of neuronal genes, cell cycle genes and remodeling genes, and is linked to regulation of genes implicated in aging and Alzheimer's disease.
CHD5 is a tumor suppressor at human 1p36.
Mills et al., United States. In Cell, 2007
Study demonstrates that Chd5 functions as a tumor suppressor in vivo and implicates deletion of CHD5 in human cancer.
Glycophorin as a possible receptor for Plasmodium falciparum.
Tanner et al., In Lancet, 1982
Tn and Wrb -ve cells with defined alterations in glycophorin A or B are also resistant to invasion.
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