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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Wingless-type MMTV integration site 9B

Wnt9b, WNT14B, WNT15
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wnt3, Wnt3a, Wnt5a, Wnt10b, Wnt8
Papers on Wnt9b
Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis.
Zhang et al., Hangzhou, China. In Dev Dyn, Jan 2016
BACKGROUND: Mutations of WNT3, WNT5A, WNT9B, and WNT11 genes are associated with orofacial birth defects, including nonsyndromic CLP (Cleft lip with cleft palate) in humans.
Mutations in WNT9B are associated with Mayer-Rokitansky-Küster-Hauser syndrome.
Ledig et al., Münster, Germany. In Clin Genet, Dec 2015
Since female Wnt9b-/- mice show a MRKHS-like phenotype, WNT9B has emerged as a promising candidate gene for this disease.
Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation.
Freed et al., Baltimore, United States. In Cell Rep, Mar 2015
Among 24 hPSC lines, two karyotypically normal lines, BG03 and CT3, and BG01V2, with trisomy 17, exhibited amplification of the WNT3/WNT9B region and rapid mDA differentiation.
Association of WNT9B Gene Polymorphisms With Nonsyndromic Cleft Lip With or Without Cleft Palate in Brazilian Nuclear Families.
Letra et al., In Cleft Palate Craniofac J, 2015
The aim of this study was to evaluate the association between polymorphisms in WNT3 and WNT9B genes and CL/P in Brazilian families.
Associations of Polymorphisms in WNT9B and PBX1 with Mayer-Rokitansky-Küster-Hauser Syndrome in Chinese Han.
Wang et al., Wuhan, China. In Plos One, 2014
Seventeen candidate loci in the AMH, PBX1, WNT4, WNT7A, WNT9B, HOXA10, HOXA11, LHXA1 and GALT genes were genotyped using the Sequenom MassARRAY iPLEX platform.
Gene-based association analysis identified novel genes associated with bone mineral density.
Lei et al., Suzhou, China. In Plos One, 2014
Especially, WNT3 and WNT9B in the Wnt signaling pathway for FN-BMD were further supported by pathway analysis and protein-protein interaction analysis.
Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder.
Mattheisen et al., Berlin, Germany. In Hum Mol Genet, 2014
We were also able to identify an association with CBE across our study samples (discovery: P = 8.88 × 10(-5); follow-up: P = 0.0025; combined: 1.09 × 10(-6)) in a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 and WNT9B.
WNT9B in 542 Chinese women with Müllerian duct abnormalities: mutation analysis.
Chen et al., Jinan, China. In Reprod Biomed Online, 2014
The WNT9B gene is a common organizing signal regulating different segments of the mammalian urogenital system and plays a primary role in the development of the female reproductive tract.
Analysis of WNT9B mutations in Chinese women with Mayer-Rokitansky-Küster-Hauser syndrome.
Wang et al., Wuhan, China. In Reprod Biomed Online, 2014
The WNT9B gene encodes a secretory glycoprotein essential for the caudal extension of the Müllerian duct during embryonic development in mice.
Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells.
Miller et al., In Hum Mol Genet, 2014
In addition, reduction of mRNA transcripts from Wnt pathway genes β-catenin, Wnt3A and Wnt9B results in DUX4 activation.
Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.
Kispert et al., Hannover, Germany. In Development, 2012
Epithelial Wnt7b and Wnt9b as possible ligands of Fzd1-mediated beta-catenin (Ctnnb1)-dependent (canonical) Wnt signaling in the undifferentiated ureteric mesenchyme
Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development.
Yoon et al., West Scarborough, United States. In Development, 2012
Study has identified a previously unknown regulatory link between WNT9B and FGF signaling during lip and upper jaw development.
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.
Kopan et al., Saint Louis, United States. In Development, 2011
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
Carroll et al., Dallas, United States. In Development, 2011
wnt9b signaling regulates stem cell proliferation and differention in the developing kidney depending on the activity of the transcription factor Six2 in the responding cell.
Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development.
Rauchman et al., Saint Louis, United States. In Development, 2010
transgenic overexpression of Wnt9b in the ureteric bud causes reduced branching in multiple founder lines.
Mouse genetic models of cleft lip with or without cleft palate.
Harris et al., Vancouver, Canada. In Birth Defects Res A Clin Mol Teratol, 2008
The mutants may reflect two interacting sets of genetic signaling pathways: Bmp4, Bmpr1a, Sp8, and Wnt9b may be in one set, and Tcfap2a and Sox11 may be in another.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
WNT3A, WNT8A, WNT8B, WNT10B and WNT11 are down-regulated in NT2 cells after ATRA treatment, while WNT2, WNT7B and WNT14B are up-regulated.
WNT and FGF gene clusters (review).
Katoh, Tokyo, Japan. In Int J Oncol, 2002
Among 19 WNT genes, WNT3 and WNT14B genes are clustered in human chromosome 17q21, WNT3A and WNT14 in human chromosome 1q42, WNT10A and WNT6 in human chromosome 2q35, and WNT10B and WNT1 in human chromosome 12q13.
WNT3-WNT14B and WNT3A-WNT14 gene clusters (Review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
Here, biological significance of WNT3-WNT14B/WNT15 gene cluster (human chromosome 17q21) and WNT3A-WNT14 gene cluster (human chromosome 1q42) will be reviewed.
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