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Wingless-type MMTV integration site family, member 8B

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wnt8, Wnt10b, Wnt3a, WNT2B, Wnt6
Papers using Wnt8b antibodies
Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways
Harris William A, In PLoS Biology, 1994
... wnt8b [49].The GFP in embryos of the her5pac:egfp transgenic line was detected by ...
Papers on Wnt8b
WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish.
Nordenskjöld et al., Stockholm, Sweden. In Hum Mol Genet, Oct 2015
In total 13 variants were identified in WNT3, WNT6, WNT7A, WNT8B, WNT10A, WNT11, WNT16, FZD5, LRP1 and LRP10 genes and predicted as potentially disease causing, of which seven variants were novel.
Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.
Oliver et al., Memphis, United States. In J Clin Invest, 2010
Neuroretina specification requires Six3-mediated suppression of Wnt8b a few hours later at the 6- to 8-somite stage.
[Mutation and expression of WNT8b gene and SHH gene in Hirschsprung disease].
Wang et al., Shenyang, China. In Zhonghua Wei Chang Wai Ke Za Zhi, 2010
WNT8b and SHH mutations and abnormal expressions are present in the peripheral blood of children with sporadic Hirschsprung disease.
Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon.
Mason et al., Edinburgh, United Kingdom. In Dev Dyn, 2010
Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon.
WNT signaling in stem cell biology and regenerative medicine.
Katoh, Tokyo, Japan. In Curr Drug Targets, 2008
WNT3, WNT5A and WNT10B are expressed in undifferentiated human embryonic stem cells, while WNT6, WNT8B and WNT10B in endoderm precursor cells.
Changes in retinoic acid signaling alter otic patterning.
Westerfield et al., Eugene, United States. In Development, 2007
We show that rhombomere 5 wnt8b expression is absent in both RA-signaling-depleted embryos and in fgf3;tcf2 double mutants, and inactivation of wnt8b in fgf3 mutants by morpholino injection results in small otic vesicles, similar to RA depletion in wild type.
Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs.
Katoh et al., Japan. In Int J Oncol, 2007
WNT8B expression in hepatocyte progenitors derived from human ES cells is due to POU5F1 (OCT3/OCT4) and GATA3, and WNT8B expression in diffuse-type gastric cancer is due to POU5F1 and GATA6
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
Redundant expression of canonical Wnt ligands in human breast cancer cell lines.
Ozturk et al., Ankara, Turkey. In Oncol Rep, 2006
We noticed that most breast cancer cell lines overexpressed WNT3A, WNT4, WNT6, WNT8B, WNT9A and WNT10B.
The zic1 gene is an activator of Wnt signaling.
Sive et al., Cambridge, United States. In Int J Dev Biol, 2005
Consistent with this result, Zic1 induces expression of several wnt genes, including wnt1, wnt4 and wnt8b.
Epithelial-mesenchymal transition in gastric cancer (Review).
Katoh, Tokyo, Japan. In Int J Oncol, 2005
Amplification of ERBB2, MET, FGFR2, PIK3CA, AKT1 genes, up-regulation of WNT2, WNT2B, WNT8B, and down-regulation of SFRP1 lead to EMT in gastric cancer through GSK3beta inhibition and following SNAIL-mediated CDH1 repression.
Homologous feeder cells support undifferentiated growth and pluripotency in monkey embryonic stem cells.
Ji et al., Kunming, China. In Stem Cells, 2005
Additionally, all monkey feeder cell lines expressed Dkk1 and LRP6, antagonists of the WNT signaling pathway, but not WNT1, WNT8B, or Dkk2.
Comparative genomics on Wnt8a and Wnt8b genes.
Katoh et al., Japan. In Int J Oncol, 2005
WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT8A, WNT8B, WNT10A and WNT10B are canonical WNTs to activate WNT - beta-catenin pathway.
Identification and characterization of rat Wnt6 and Wnt10a genes in silico.
Katoh et al., Japan. In Int J Mol Med, 2005
Xenopus aristaless-related homeobox (xARX) gene product functions as both a transcriptional activator and repressor in forebrain development.
El-Hodiri et al., Columbus, United States. In Dev Dyn, 2005
However, expression of some markers, dlx5 and wnt8b, was enhanced in xArx-injected embryos.
Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain.
Lekven et al., College Station, United States. In Dev Dyn, 2004
Several wnt genes (wnt1, wnt3a, wnt8b, and wnt10b) show elevated expression at rhombomere boundaries, whereas several delta genes (dlA, dlB, and dlD) are expressed in transverse stripes flanking rhombomere boundaries.
nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development.
Moon et al., Seattle, United States. In Development, 2004
Inhibition of nlk using morpholino oligos reveals essential roles in regulating ventrolateral mesoderm formation in conjunction with wnt8, and in patterning of the midbrain, possibly functioning with wnt8b.
Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
WNT3A, WNT8A, WNT8B, WNT10B and WNT11 are down-regulated in NT2 cells after ATRA treatment, while WNT2, WNT7B and WNT14B are up-regulated.
Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish.
Huh et al., Taegu, South Korea. In Development, 2002
Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish.
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