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Wingless-related MMTV integration site 7B

This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008] (from NCBI)
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Top mentioned proteins: Wnt5a, WNT2B, Wnt3a, Wnt3, WNT10A
Papers on Wnt7b
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the ligands and receptors of the Wnt signaling pathway.
Further evidence of the involvement of the Wnt signaling pathway in Dupuytren's disease.
Werker et al., Groningen, Netherlands. In J Cell Commun Signal, Jan 2016
A genome-wide association study (GWAS) showed that nine loci are associated with the disease, six of which contain genes that are involved in Wnt signaling (WNT2, WNT4, WNT7B, RSPO2, SFRP4, SULF1).
Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts.
Sannes et al., Raleigh, United States. In J Histochem Cytochem, Dec 2015
Further, isolated lung fibroblasts from normal or IPF human lungs, adenovirally transduced for the overexpression or silencing of Wnt7B or treated with TGF-β1 or its inhibitor, were analyzed for Wnt5A protein expression.
Beta-catenin in schizophrenia: Possibly deleterious novel mutation.
Malashichev et al., Saint Petersburg, Russia. In Psychiatry Res, Sep 2015
The gene list included CTNNB1 (beta-catenin), GSK3B, WNT2B and WNT7B.
GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.
St Croix et al., Frederick, United States. In Cell Rep, Feb 2015
Similar developmental defects were observed following dual deletion of Wnt7a/Wnt7b or deletion of β-catenin in endothelial cells, suggesting a possible relationship between GPR124 and canonical WNT signaling.
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.
Yoshimura et al., Kyoto, Japan. In Nat Commun, 2014
We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9
High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells.
van Wijnen et al., Rochester, United States. In J Cell Biochem, 2014
Strikingly, AMSCs modulate expression of WNT signaling components and switch production of WNT ligands (from WNT5A/WNT5B/WNT7B to WNT2/WNT2B), while upregulating WNT-related genes (WISP2, SFRP2, and SFRP4).
Up-regulation of fibroblast growth factor (FGF) 9 expression and FGF-WNT/β-catenin signaling in laser-induced wound healing.
Cho et al., Yanji, China. In Wound Repair Regen, 2014
Control NHEKs constitutively expressed FGF9, WNT7b, WNT2, and β-catenin, but did not show Snail or FGF receptor (FGFR) 2 expression.
Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer.
Lang et al., Edinburgh, United Kingdom. In Cancer Res, 2014
Interrogation of the Oncomine database revealed that 52 of 53 human breast carcinomas showed substantial upregulation of WNT family ligand WNT7B.
Canonical Wnt signaling activity in early stages of chick lung development.
Correia-Pinto et al., Braga, Portugal. In Plos One, 2013
The present work characterizes, for the first time, the expression pattern of several Wnt signaling members, such as wnt-1, wnt-2b, wnt-3a, wnt-5a, wnt-7b, wnt-8b, wnt-9a, lrp5, lrp6, sfrp1, dkk1, β-catenin and axin2 at early stages of chick lung development.
Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.
Kispert et al., Hannover, Germany. In Development, 2012
Epithelial Wnt7b and Wnt9b as possible ligands of Fzd1-mediated beta-catenin (Ctnnb1)-dependent (canonical) Wnt signaling in the undifferentiated ureteric mesenchyme.
c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease.
Kreidberg et al., Boston, United States. In J Am Soc Nephrol, 2012
Hyperactivated c-Met led to increased NF-kappaB signaling, which in turn, drove de novo expression of Wnt7a and overexpression of Wnt7b in Pkd1(-/-) mouse kidneys.
Wnt signaling and Dupuytren's disease.
BSSH-GODD Consortium et al., Groningen, Netherlands. In N Engl J Med, 2011
odds ratio, 0.72), and WNT7B (rs6519955) (P=3.2×10(-33);
Targeting androgen receptor in estrogen receptor-negative breast cancer.
Brown et al., Boston, United States. In Cancer Cell, 2011
Through analysis of the AR cistrome and androgen-regulated gene expression in ER-/HER2+ breast cancers we find that AR mediates ligand-dependent activation of Wnt and HER2 signaling pathways through direct transcriptional induction of WNT7B and HER3.
Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling.
Vainio et al., Oulu, Finland. In Dev Biol, 2011
Dkk1 controls the degree of Wnt-7b signalling in the papilla to coordinate kidney organogenesis.
Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem.
Pasterkamp et al., San Diego, United States. In J Neurosci, 2010
Both Wnt5a and Wnt7b are expressed in gradients along the anterior-posterior axis of the brainstem, consistent with their role as directional cues.
Macrophage Wnt7b is critical for kidney repair and regeneration.
Duffield et al., Boston, United States. In Proc Natl Acad Sci U S A, 2010
Because Wnt7b is known to stimulate epithelial responses during kidney development, these findings suggest that macrophages are able to rapidly invade an injured tissue and reestablish a developmental program that is beneficial for repair and regeneration
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature.
Lang et al., Cincinnati, United States. In Nature, 2005
macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye
Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
WNT3A, WNT8A, WNT8B, WNT10B and WNT11 are down-regulated in NT2 cells after ATRA treatment, while WNT2, WNT7B and WNT14B are up-regulated.
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