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Wingless-type MMTV integration site family, member 2B

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternatively spliced transcript variants. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: Wnt5a, DM2, ACID, Frizzled, TCF
Papers on WNT2B
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
Numerous frizzled receptors (fzd1, fzd2, fzd3, fzd4, fzd6, fzd7, fzd8, and fzd10) and wnt ligands (wnt2b.a,
Downregulation of the Canonical WNT Signaling Pathway by TGFβ1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics.
Limb et al., London, United Kingdom. In Stem Cells Dev, Feb 2016
Culture of hMSC with a combination of factors that induce photoreceptor differentiation of hMSC (FGF2, taurine, retinoic acid, and insulin-like growth factor type1; FTRI), markedly upregulated the expression of components of the canonical Wnt signaling pathway, including WNT2B, DKK1, and active β-CATENIN.
[Analysis of gastric cancer tissues genome methylation by DNA methylation chip].
Li et al., Zhangjiakou, China. In Zhonghua Wei Chang Wai Ke Za Zhi, Nov 2015
In the CpG islands, 123 significantly different methylated genes were identified in gastric cancer tissues, such as WNT2B, JAK2 and TPT1, while 139 significantly different methylated genes were identified in their matched adjacent tissues, such as TNFRSF4, HOXC8 and NFYA.
Beta-catenin in schizophrenia: Possibly deleterious novel mutation.
Malashichev et al., Saint Petersburg, Russia. In Psychiatry Res, Sep 2015
The gene list included CTNNB1 (beta-catenin), GSK3B, WNT2B and WNT7B.
Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle.
Price et al., Saint-Hyacinthe, Canada. In Mol Cell Endocrinol, Apr 2015
Cells cultured in serum-free medium expressed mRNA encoding WNT2B, WNT5B and WNT5A.
miR-185-3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro.
Qiu et al., Changsha, China. In Cancer Sci, 2014
A negative correlation between miR-185-3p and WNT2B expression was observed in NPC cells and tissues.
Interaction of Wnt pathway related variants with type 2 diabetes in a Chinese Han population.
Lu et al., Beijing, China. In Peerj, 2014
rs2273368(C) in WNT2B, p = 4.46∗10(-3), OR = 1.23, 95% CI [1.11-1.32],
Antitumor effects of WNT2B silencing in GLUT1 overexpressing cisplatin resistant head and neck squamous cell carcinoma.
Qian et al., Shanghai, China. In Am J Cancer Res, 2014
And WNT2B overexpression is thought to be involved in tumor progression.
[The expression and significance of miRNA-324-3p and WNT2B in nasopharyngeal carcinoma].
Qiu et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2014
OBJECTIVE: To investigate the expression and significance of miRNA-324-3p and its target gene WNT2B in tissue specimens of nasopharyngeal carcinoma (NPC) specimens.
Canonical Wnt signaling activity in early stages of chick lung development.
Correia-Pinto et al., Braga, Portugal. In Plos One, 2013
The present work characterizes, for the first time, the expression pattern of several Wnt signaling members, such as wnt-1, wnt-2b, wnt-3a, wnt-5a, wnt-7b, wnt-8b, wnt-9a, lrp5, lrp6, sfrp1, dkk1, β-catenin and axin2 at early stages of chick lung development.
Silencing Wnt2B by siRNA interference inhibits metastasis and enhances chemotherapy sensitivity in ovarian cancer.
Huang et al., Wuhan, China. In Int J Gynecol Cancer, 2012
High Wnt2B overexpression is associated with ovarian cancer metastasis and drug resistance.
Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.
Tanaka et al., Kumamoto, Japan. In Proc Natl Acad Sci U S A, 2011
targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Katoh et al., Japan. In Curr Mol Med, 2009
Hedgehog signals directly upregulate JAG2, indirectly upregulate mesenchymal BMP4 via FOXF1 or FOXL1, and also upregulate WNT2B and WNT5A.
Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals.
Katoh et al., Japan. In Int J Oncol, 2009
Hedgehog signals and bHLH transcription factors are involved in WNT2B upregulation, which is counteracted by BMP, WNT and Notch signals.
[Identification of heplipin inducing apoptosis-related genes in KG-1 human leukemia cells by differential display RT-PCR].
Wang et al., Dalian, China. In Zhonghua Xue Ye Xue Za Zhi, 2007
Heplipin induced KG-1 cell apoptosis is related with Wntl3 and ATPase3.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
Mesodermal Wnt2b signalling positively regulates liver specification.
Stainier et al., San Francisco, United States. In Nature, 2006
data reveal an unexpected positive role for Wnt signalling in liver specification, and indicate a possible common theme for the localized formation of endodermal organs along the gut tube
WNT2B: comparative integromics and clinical applications (Review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2005
REVIEW: Anti-WNT2B monoclonal antibodies, WNT2B RNAi compounds, or small molecule WNT2B inhibitors could be developed as novel therapeutic agents for gastric cancer and esophageal cancer in the field of clinical oncology.
Epithelial-mesenchymal transition in gastric cancer (Review).
Katoh, Tokyo, Japan. In Int J Oncol, 2005
Amplification of ERBB2, MET, FGFR2, PIK3CA, AKT1 genes, up-regulation of WNT2, WNT2B, WNT8B, and down-regulation of SFRP1 lead to EMT in gastric cancer through GSK3beta inhibition and following SNAIL-mediated CDH1 repression.
WNT2 and human gastrointestinal cancer (review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2003
WNT2 gene on human chromosome 7q31 is a paralog of the WNT2B gene on human chromosome 1p13.
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