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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Zinc finger, matrin-type 3

Wig-1, PAG608, p53-activated gene 608
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, CAN, Bax, p21, mdm2
Papers on Wig-1
[Influence of interference of WIG-1 on the multi-drug resistance in small cell lung cancer].
Lan et al., Chengdu, China. In Zhonghua Zhong Liu Za Zhi, 2014
OBJECTIVE: To investigate the role of wild-type p53-induced gene 1 (WIG-1) on the regulation of multi-drug resistance in small cell lung cancer.
Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma.
Andersson et al., Stockholm, Sweden. In Plos One, 2013
The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplified in human tumors, including cervical cancer.
Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta.
Rotter et al., Israel. In Plos One, 2012
IFN╬▓ on the other hand, reduced mutant p53 RNA levels by restricting its RNA stabilizer, WIG1.
Effect of altered WIG-1 expression on DDP sensitivity in a DDP-resistant esophageal squamous cancer cell line.
Guo et al., Chongqing, China. In Curr Cancer Drug Targets, 2012
The wide-type p53 induced gene 1 (WIG-1) is a p53-regulated transcription factor.
Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth.
Wiman et al., Stockholm, Sweden. In Cell Death Dis, 2011
Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc.
Genomic analysis of wig-1 pathways.
Monia et al., Carlsbad, United States. In Plos One, 2011
BACKGROUND: Wig-1 is a transcription factor regulated by p53 that can interact with hnRNP A2/B1, RNA Helicase A, and dsRNAs, which plays an important role in RNA and protein stabilization. in vitro studies have shown that wig-1 binds p53 mRNA and stabilizes it by protecting it from deadenylation.
Zinc induces cell cycle arrest and apoptosis by upregulation of WIG-1 in esophageal squamous cancer cell line EC109.
Ma et al., Chongqing, China. In Tumour Biol, 2011
WIG-1 might be involved in the zinc-induced cell cycle arrest and apoptosis of human esophageal squamous cell carcinoma cells
The alphaherpesvirus US3/ORF66 protein kinases direct phosphorylation of the nuclear matrix protein matrin 3.
Kinchington et al., Pittsburgh, United States. In J Virol, 2011
The cellular distribution of the nuclear matrix protein matrin 3 is altered by novel phosphorylation induced by the alphaherpesvirus US3 kinase family.
Preparation of a novel monoclonal antibody specific for WIG-1 and detection of its expression pattern in human esophageal carcinoma.
Ma et al., Chongqing, China. In Hybridoma (larchmt), 2010
WIG-1 might be a novel modifier in esophageal carcinogenesis, and the WIG-1 MAb should be useful in further study of the mechanism in WIG-1-related physiological reactions.
Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene.
Abe et al., Okayama, Japan. In J Neurosci Res, 2010
The activated form of p53 also increased and translocated to the nuclei of spinal motor neurons, followed by increased expression of p53-activated gene 608 (PAG608).
The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.
Wiman et al., Stockholm, Sweden. In Proc Natl Acad Sci U S A, 2009
the p53 target Wig-1 is a previously undescribed AU-rich element-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response
Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells.
Pastor-Anglada et al., Barcelona, Spain. In Haematologica, 2008
RESULTS: Sixteen of the twenty genes (DDB2, GADD45A, TYMS, BAX, TIGAR, FAS, TNFSF7, TNFSF9, CCNG1, CDKN1A, MDM2, SESN1, MAP4K4, PPM1D, OSBPL3 and WIG1) correlated with the ex vivo sensitivity of chronic lymphocytic leukemia cells to fludarabine, TIGAR (TP53-induced glycolysis and apoptosis regulator) being the gene that showed the strongest correlation (p<0.0001;
Specific induction of PAG608 in cranial and spinal motor neurons of L-DOPA-treated parkinsonian rats.
Ogawa et al., Okayama, Japan. In Neurosci Res, 2008
The specific induction of PAG608 6-48h after L-DOPA injection in the extrapyramidal tracts, pyramidal tracts and corresponding lower motor neurons of the spinal cords suggests its involvement in molecular events in stimulated motor neurons.
Suppression of p53-activated gene, PAG608, attenuates methamphetamine-induced neurotoxicity.
Ogawa et al., Okayama, Japan. In Neurosci Lett, 2007
Methamphetamine neurotoxicity in monoaminergic cells is related, at least in part, to induction of PAG608 expression.
MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.
Gil et al., Barcelona, Spain. In Blood, 2006
Nutlin-3 stabilized p53 and induced p53 target genes, including MDM2, p21(CIP1), PUMA, BAX, PIG3, and WIG1.
Erythropoietin in thyroid cancer.
Francis et al., Bethesda, United States. In J Endocrinol Invest, 2006
Importantly, however, administration of Epo to NPA but not WRO cells resulted in significant alterations in the expression of several mitogenic genes including cyclooxygenase-2 (COX-2), beta-casein (CSN2), wild type p53-induced gene-1 (WIG1) and cathepsin D (CTSD).
Differential gene expression between Zucker Fatty rats and Zucker Diabetic Fatty rats: a potential role for the immediate-early gene Egr-1 in regulation of beta cell proliferation.
Boam et al., Manchester, United Kingdom. In J Mol Endocrinol, 2005
Thus a subset of those with no role yet defined in the beta-cell was selected for further study namely the immediate-early gene Egr-1, PAG608, rCGR19 and mSin3b.
Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression.
Recio et al., United States. In Stem Cells, 2003
Males exposed to benzene exhibited higher mRNA levels for xpc, ku80, ccng, and wig1.
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