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WNT inhibitory factor 1

WIF1, Wnt inhibitory factor-1
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: SFRP1, CAN, DKK1, SFRP2, APC
Papers on WIF1
An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.
Umar et al., Kansas City, United States. In Carcinogenesis, Feb 2016
Moreover, WIF1 (a Wnt antagonist) promoter activity increased dramatically following treatment with AR extract which phenocopied increases in WIF1 reporter activity following EZH2 knockdown.
Norcantharidin blocks Wnt/β-catenin signaling via promoter demethylation of WIF-1 in glioma.
Yang et al., Hangzhou, China. In Oncol Rep, Feb 2016
Accordingly, we aimed to investigate NCTD as an anti-neoplastic drug that inhibits the Wnt/β‑catenin pathway via promoter demethylation of Wnt inhibitory factor-1 (WIF-1) in glioma growth in vitro.
Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.
Ushijima et al., Tokyo, Japan. In Mol Carcinog, Feb 2016
Regarding individual pathways affected in ESCCs, the WNT pathway was activated potentially by aberrant methylation of its negative regulators, such as SFRP1, SFRP2, SFRP4, SFRP5, SOX17, and WIF1 (33%).
MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis.
Zheng et al., Wenzhou, China. In Oncotarget, Jan 2016
Interestingly, Sal B treatment induced the inactivation of Wnt/β-catenin pathway, with an increase in P-β-catenin and Wnt inhibitory factor 1 (WIF1).
Wnt pathway in Dupuytren disease: connecting profibrotic signals.
Bank et al., Groningen, Netherlands. In Transl Res, Dec 2015
On the contrary, the strongest downregulated genes in this study were 4 antagonists of Wnt signaling (DKK1, FRZB, SFRP1, and WIF1).
Abnormal expression of WIF1 in hepatocellular carcinoma cells and its regulating effect on invasion and metastasis factors of TIMP-3 and caveolin-1 of hepatocellular carcinoma.
Li et al., Tangshan, China. In Asian Pac J Trop Med, Nov 2015
OBJECTIVE: To discuss the abnormal expression of Wnt inhibitory factor (WIF1) in hepatocellular carcinoma cells and its regulating effect on the hepatocellular carcinoma invasion and metastasis factors of tissue inhibitor of matrix metalloproteinases-3 (TIMP-3) and caveolin-1.
The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic ductal adenocarcinoma by regulating the expression of Wnt inhibitory factor 1.
Chen et al., Guangzhou, China. In Tumour Biol, Nov 2015
Furthermore, the correlation between HOTAIR and Wnt inhibitory factor 1 (WIF-1) expression in PDAC cell lines and tissues was studied to assess the role of HOTAIR and WIF-1 in the radiosensitivity of PDAC.
The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance.
Tang et al., Kunming, China. In Acta Biochim Biophys Sin (shanghai), 2014
miR-331-3p, miR-130a, miR-7, miR-141, HER2, c-MYC, WIF-1, RBM38, PTEN, and Col-1 are involved in the HOTAIR regulation network.
Extracellular modulators of Wnt signalling.
Jones et al., United States. In Curr Opin Struct Biol, 2014
Structures include Wnt in complex with the cysteine-rich domain (CRD) of Frizzled, extracellular fragments of Wnt co-receptor LRP6, LRP6-binding antagonists Dickkopf and Sclerostin, antagonists 5T4/WAIF1 and Wnt inhibitory factor 1 (WIF-1), as well as Frizzled-ubiquitin ligases ZNRF3/RNF43 (in isolation and in complexes with Wnt signalling promoters R-spondins and LGR5).
Wnt signaling pathway in non-small cell lung cancer.
Stewart, Ottawa, Canada. In J Natl Cancer Inst, 2014
Downregulation of Wnt inhibitors (eg, by hypermethylation) is common in NSCLC tumor cell lines and resected samples; may be associated with high stage, dedifferentiation, and poor prognosis; and has been reported for AXIN, sFRPs 1-5, WIF-1, Dkk-1, Dkk-3, HDPR1, RUNX3, APC, CDX2, DACT2, TMEM88, Chibby, NKD1, EMX2, ING4, and miR-487b.
Hematopoietic stem cell fate decisions are regulated by Wnt antagonists: comparisons and current controversies.
Manilay et al., Merced, United States. In Exp Hematol, 2013
Secreted frizzled related proteins-1 and -2, Wnt inhibitory factor-1, Dickkopf-1, and Sclerostin are Wnt antagonists that influence hematopoietic cell fate decisions in the bone marrow niche.
Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo.
Queimado et al., Oklahoma City, United States. In Oncogene, 2012
Loss of WIF1 is associated with cervical cancer.
The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity.
Stock et al., Erlangen, Germany. In J Cell Physiol, 2012
Data show that Wif-1 can interfere with CTGF-dependent induction of gene expression in primary murine chondrocytes, and indicate that Wif-1 may be a multifunctional modulator of signalling pathways in the cartilage compartment.
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium et al., Seattle, United States. In Nat Genet, 2012
In two additional samples (n = 2,318), associations were replicated at 12q14 within MSRB3-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10(-11)) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 × 10(-11)).
Smad1 and WIF1 genes are downregulated during saccular stage of lung development in the nitrofen rat model.
Puri et al., Dublin, Ireland. In Pediatr Surg Int, 2012
downregulation of Smad1/Wif1 gene expression may contribute to pulmonary hypoplasia in the nitrofen CDH model by retardation of lung development during saccular stage.
Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants.
Gong et al., Singapore, Singapore. In Biochim Biophys Acta, 2012
Data describe the importance of proper level of Wnt signaling for normal development of swimbladder in Wif1 morphant zebrafish.
[Study of WIF-1 promoter methylation with expressions of β-catenin in acute leukemia].
Hou et al., Jinan, China. In Zhonghua Yi Xue Za Zhi, 2011
The methylation of WIF-1 gene promoter and beta-catenin may be involved in the abnormal activation of Wnt/beta-catenin signal in acute leukemia.
[Research progress of Wif1 in development of nervous system].
Zhao et al., Nanjing, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010
Wnt inhibitor factor-1 (WIF-1) is an extracellular antagonist of Wnts secreted proteins, first characterized as an expressed sequence tag in the human retina.
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis.
Torres et al., Córdoba, Spain. In J Clin Oncol, 2005
PATIENTS AND METHODS: Methylation-specific polymerase chain reaction was used to analyze methylation of the ADAMTS-1, ADAMTS-5, APAF-1, ASPP-1, CDH1, CDH13, DAPK, DIABLO, DKK-3, LATS-1, LATS-2, NES-1, p14, p15, p16, p57, p73, PARK-2, PTEN, sFRP1/2/4/5, SHP-1, SYK, TMS-1, and WIF-1 genes in samples from 50 consecutive T-ALL patients (19 children and 31 adults).
A new secreted protein that binds to Wnt proteins and inhibits their activities.
Nathans et al., Baltimore, United States. In Nature, 1999
Here we describe Wnt-inhibitory factor-1 (WIF-1), a secreted protein that binds to Wnt proteins and inhibits their activities.
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