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6 documents found
1: Title: Znhit1 inhibits breast cancer by up-regulating PTEN to deactivate the PI3K/Akt/mTOR pathway.
Authors: Cui, Chunguo, et.al. .
Journal: Life sciences (Life Sci), 2019 .
Snippet: The interactions among Znhit1, PTEN and the downstream PI3K/Akt/mTOR pathway were evaluated by Western blot analysis.
Affiliation: Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun 130031, China. Department of Breast Surgery, The First Hospital of Jilin University, Changchun 130021, China. Department of Breast Surgery, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: wudi0028lby@sina.com. .
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2: Title: Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation.
Authors: Zhao, Bing, et.al. .
Journal: Nature communications (Nat Commun), Vol. 10 (1): 1071, 2019 .
Snippet: Mechanistically, Znhit1 incorporates histone variant H2A.Z into TSS region of genes involved in Lgr5+ stem cell fate determination, including Lgr5, Tgfb1 and Tgfbr2, for subsequent transcriptional regulation.
Affiliation: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. bingzhao@fudan.edu.cn. Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. bingzhao@fudan.edu.cn. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. National Laboratory of Biomacromolecules, CAS Center for Excellence in Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. xlin@fudan.edu.cn. Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA. xlin@fudan.edu.cn. .
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3: Title: Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2.
Authors: Ye, Buqing, et.al. .
Journal: Nature communications (Nat Commun), Vol. 8 (1): 1518, 2017 .
Snippet: In MPPs, Pcid2 interacts with the Zinc finger HIT-type containing 1 (ZNHIT1) to block Snf2-related CREBBP activator protein (SRCAP) activity and prevents the deposition of histone variant H2A.Z and transcription factor PU.1 to key lymphoid fate regulator genes.
Affiliation: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. University of Chinese Academy of Sciences, Beijing, 100049, China. WPI Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan. Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, 02115, USA. Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. fanz@moon.ibp.ac.cn. University of Chinese Academy of Sciences, Beijing, 100049, China. fanz@moon.ibp.ac.cn. .
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4: Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
Authors: Cuadrado, Ana, et.al. .
Journal: The EMBO journal (Embo J), Vol. 29 (12): 2014-25, 2010 .
Snippet: We show that the SRCAP subunit named ZNHIT1 or p18(Hamlet), which is a substrate of p38 MAPK, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 MAPK-dependent manner.
Affiliation: Spanish National Cancer Center (CNIO), Madrid, Spain. acuadrado@cnio.es .
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5: Title: Znhit1 causes cell cycle arrest and down-regulates CDK6 expression.
Authors: Yang, Zhengmin, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 386 (1): 146-52, 2009 .
Snippet: In this study, Znhit1, a member of a new zinc finger protein family defined by a conserved Zf-HIT domain, induced arrest in the G1-phase of the cell cycle in NIH/3T3 cells.
Affiliation: Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. .
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6: Title: p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents.
Authors: Lafarga, Vanesa, et.al. .
Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle), Vol. 6 (19): 2319-22, 2007 .
Snippet: We recently characterized a new p38alpha substrate, named p18(Hamlet) (ZNHIT1), which mediates p53-dependent responses to different genotoxic stresses.
Affiliation: CNIO (Spanish National Cancer Center), Madrid, Spain. .
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