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11 documents found
1: Title: Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma.
Authors: Kwon, Ryuk-Jun, et.al. .
Journal: PloS one, Vol. 12 (2): e0171036, 2017 .
Snippet: Zinc fingers and homeoboxes (ZHX) is a transcription repressor family that contains three members; ZHX1, ZHX2, and ZHX3.
Affiliation: Departments of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea. Gene & Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan, Republic of Korea. Department of Statistics, Korea University, Seongbuk-gu, Seoul, Republic of Korea. Departments of Physiology, School of Medicine, Pusan National University, Yangsan, Republic of Korea. .
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2: Title: Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages.
Authors: Chang, Isabelle, et.al. .
Journal: Gene expression patterns : GEP (Gene Expr Patterns), Vol. 21 (2): 69-80, 2016 .
Snippet: We identified 11 homeobox genes (Dlx3, Dlx4, Emx2, Lhx2, Meis1, Pbx3, Pknox2, Pou6f1, Tshz2, Zhx1, Zhx3) that were expressed exclusively in neurons; 4 homeobox genes (Pax6, Six1, Tgif1, Zfhx3) that were expressed in all non-neuronal cell populations, with Pax6, Six1 and Tgif1 also expressed in some neuronal progenitors and precursors; 12 homeobox genes (Adnp, Cux1, Dlx5, Dlx6, Meis2, Pbx2, Pknox1, Pou2f1, Satb1, Tshz1, Tshz3, Zhx2) with expression in both neuronal and non-neuronal cell populations; and one homeobox gene (Hopx) that was exclusively expressed in the non-sensory epithelium.
Affiliation: Max Planck Research Unit for Neurogenetics, Max-von-Laue-Strasse 4, 60438, Frankfurt, Germany. Electronic address: isabelle.chang@gen.mpg.de. Max Planck Research Unit for Neurogenetics, Max-von-Laue-Strasse 4, 60438, Frankfurt, Germany. .
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3: Title: [Effect of echinacoside-containing serum in promoting mesenchymal stem cell osteogenic differentiation and ZHX₃ expression in rats].
Authors: Tian, Yuan, et.al. .
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi), Vol. 40 (20): 4052-7, 2015 .
Snippet: In conclusion, 10% echinacoside-containing serum can promote the differentiation of the bone marrow mesenchymal stem cells cultured in vitro.
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4: Title: Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
Authors: Mahajan, Anubha, et.al. .
Journal: PLoS genetics (Plos Genet), Vol. 11 (1): e1004876, 2015 .
Snippet: Coding variant associations for glycemic traits in GWAS signals highlight PCSK1, RREB1, and ZHX3 as likely effector transcripts.
Affiliation: Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America. Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Health Studies, Biostatistics Laboratory, The University of Chicago, Chicago, Illinois, United States of America. School of Computer Science, McGill University, Montreal, Quebec, Canada; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden. High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom. Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, United States of America. Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America. Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America. Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. Blood Systems Research Institute, San Francisco, California, United States of America; Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, California, United States of America. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America. Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark. Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark. Foundation for Research in Health, Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, United Kingdom. Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden. Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark. Department of Social Services and Health Care, Jakobstad, Finland; Folkhälsan Research Centre, Helsinki, Finland. Folkhälsan Research Centre, Helsinki, Finland; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland. Steno Diabetes Center, Gentofte, Denmark. Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark; Faculty of Medicine, University of Aalborg, Aalborg, Denmark. Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland; Kuopio University Hospital, Kuopio, Finland. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. National Institute for Health and Welfare, Helsinki, Finland. Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, United Kingdom. Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, United Kingdom. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, United States of America. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia; Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain; Center for Vascular Prevention, Danube University Krems, Krems, Austria; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom. National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, United Kingdom. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom; Estonian Genome Centre, University of Tartu, Tartu, Estonia. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. General Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, United Kingdom. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America. .
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5: Title: Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia.
Journal: Circulation. Cardiovascular genetics (Circ Cardiovasc Genet), Vol. 5 (1): 66-72, 2012 .
Snippet: METHODS AND RESULTS: We resequenced protein coding regions of 3 genes with established roles (APOC2, GPIHBP1, LMF1) and 2 genes recently implicated (CREB3L3 and ZHX3) in TG metabolism.
Affiliation: Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada. .
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6: Title: Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation.
Authors: Suehiro, Fumio, et.al. .
Journal: Stem cells and development (Stem Cells Dev), Vol. 20 (9): 1539-47, 2011 .
Snippet: We propose zinc fingers and homeoboxes 3 (ZHX3) as new osteogenic markers for mesenchymal stem cells (MSC).
Affiliation: Department of Prosthetic Dentistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. .
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7: Title: The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension.
Authors: Wienk, Hans, et.al. .
Journal: Biochemistry, Vol. 48 (21): 4431-9, 2009 .
Snippet: The high degree of sequence conservation among ZHX family members permitted us to prepare homology models for ZHX2 and ZHX3, revealing distinct surface characteristics for each family member.
Affiliation: Bijvoet Center for Biomolecular Research, NMR Spectroscopy Research Group, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. .
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8: Title: ZHX2 and ZHX3 repress cancer markers in normal hepatocytes.
Authors: Yamada, Kazuya, et.al. .
Journal: Frontiers in bioscience (Landmark edition) (Front Biosci), Vol. 14, 2009 .
Snippet: Upon the reporter gene analysis utilizing the promoter region of these genes, ZHX3 repressed the transcription of the reporter luciferase gene from both promoters while ZHX2 only repressed that from HK II promoter.
Affiliation: Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan. kazuya.yamada@matsu.ac.jp .
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9: Title: ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.
Authors: Liu, Gang, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 281 (51): 39681-92, 2006 .
Snippet: While studying mechanisms of glomerular disease, rat ZHX3 was cloned from a down-regulated gene fragment; its cellular localization, DNA binding, and transcriptional repressor properties were characterized; and its ability to influence podocyte gene expression directly or via ZHX1 and ZHX2 was studied.
Affiliation: Division of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. .
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10: Title: The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3.
Authors: Kawata, Hiroko, et.al. .
Journal: Gene, Vol. 323, 2003 .
Snippet: The cloning of mouse ZHX2 and ZHX3 cDNAs and the corresponding genes from a 129 mouse genomic library are reported, along with an analysis of the heterodimerization of ZHX2 with ZHX3.
Affiliation: CREST, JST (Japan Science and Technology), 910-1193, Fukui, Japan. .
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11: Title: Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.
Authors: Yamada, Kazuya, et.al. .
Journal: The Biochemical journal (Biochem J), Vol. 373 (Pt 1): 167-78, 2003 .
Snippet: ZHX3 not only dimerizes with both ZHX1 and ZHX3, but also interacts with the activation domain of the NF-YA.
Affiliation: Department of Biochemistry, Fukui Medical University, and Japan and CREST, Japan Science and Technology, Fukui 910-1193, Japan. kazuya@fmsrsa.fukui-med.ac.jp .
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