refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
21 documents found
1: Title: ZDHHC3 as a Risk and Mortality Marker for Breast Cancer in African American Women.
Authors: Kinney, Nick, et.al. .
Journal: Cancer informatics (Cancer Inform), Vol. 16, 2017 .
Snippet: These are located in the 3' UTR (untranslated region) of gene ZDHHC3, an intron of transcribed pseudogene INTS4L1, an intron of ribosomal gene RNA5-8S5, and an intergenic region of chromosome 16.
Affiliation: Center for Bioinformatics and Genetics & Primary Care Research Network, Edward Via College of Osteopathic Medicine, Blacksburg, VA, USA. Gibbs Cancer Center & Research Institute, Spartanburg, SC, USA. .
Related Products: order online
2: Title: Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a.
Authors: Spinelli, Matteo, et.al. .
Journal: Nature communications (Nat Commun), Vol. 8 (1): 2009, 2017 .
Snippet: The excess of palmitic acid along with higher zDHHC3 levels causes hyper-palmitoylation of AMPA glutamate receptor subunit GluA1, hindering its activity-dependent trafficking to the plasma membrane.
Affiliation: Institute of Human Physiology, Università Cattolica Medical School, 00168, Rome, Italy. Institute of Human Physiology, Università Cattolica Medical School, 00168, Rome, Italy. salvatore.fusco@unicatt.it. San Raffaele Pisana Scientific Institute for Research, Hospitalization and Health Care, 00163, Rome, Italy. salvatore.fusco@unicatt.it. Department of Chemistry and Biology, University of Salerno, 84084, Salerno, Italy. Fondazione Policlinico Gemelli, 00168, Rome, Italy. .
Related Products: order online
3: Title: The absence of DHHC3 affects primary and latent HSV-1 infection.
Authors: Wang, Shaohui, et.al. .
Journal: Journal of virology (J Virol), 2017 .
Snippet: We reported recently that UL20 can bind to a host protein encoded by the zinc finger DHHC-type containing 3 (ZDHHC3) gene (also known as Golgi-specific DHHC zinc finger protein {GODZ}).
Affiliation: Center for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, CA. Brain Research Institute, UCLA, Los Angeles, CA. Department of Biology, Biochemistry & Molecular Biology, and Psychiatry, Pennsylvania State University, University Park, PA. Eye Program, Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, and David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA. Division of Biotechnology and Molecular Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA. Infectious Disease Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Center for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, CA ghiasih@cshs.org. .
Related Products: order online
4: Title: The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.
Authors: McMichael, Temet M, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (52): 21517-21526, 2017 .
Snippet: Unlike knock-out of individual ZDHHCs, siRNA-mediated knockdown of both ZDHHC3 and ZDHHC7 in ZDHHC20 knock-out cells decreased endogenous IFITM3 palmitoylation.
Affiliation: From the Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210 and. Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065. From the Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio 43210 and yount.37@osu.edu. .
Related Products: order online
5: Title: Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence.
Authors: Sharma, Chandan, et.al. .
Journal: Cancer research (Cancer Res), Vol. 77 (24): 6880-6890, 2017 .
Snippet: ZDHHC3-ablated tumors also showed enhanced recruitment of innate immune cells (antitumor macrophages, natural killer cells) associated with clearance of senescent tumors.
Affiliation: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts. martin_hemler@dfci.harvard.edu. .
Related Products: order online
6: Title: Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K.
Authors: Wang, Shaohui, et.al. .
Journal: Journal of virology (J Virol), Vol. 91 (19), 2017 .
Snippet: In this study, we show that (i) HSV-1 UL20 binds to GODZ (also known as DHHC3), a Golgi apparatus-specific Asp-His-His-Cys (DHHC) zinc finger protein; (ii) a GODZ dominant-negative mutant and an inhibitor of palmitoylation reduced HSV-1 titers and altered the localization of UL20 and glycoprotein K; and (iii) UL20 is palmitoylated by GODZ, and this UL20 palmitoylation is required for HSV-1 infectivity.
Affiliation: Center for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, USA. Division of Biotechnology and Molecular Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA. Department of Biology, Biochemistry & Molecular Biology, and Psychiatry, Penn State University, University Park, Pennsylvania, USA. Center for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, USA ghiasih@cshs.org. .
Related Products: order online
7: Title: Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis.
Authors: Boucher, Joshua M, et.al. .
Journal: Nature communications (Nat Commun), Vol. 8, 2017 .
Snippet: Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis.
Affiliation: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. Genetics and Molecular Biology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. .
Related Products: order online
8: Title: Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.
Authors: Greaves, Jennifer, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 114 (8): E1365-E1374, 2017 .
Snippet: This difference in selectivity was apparent even for highly related enzymes, such as zDHHC3 and zDHHC7, which displayed a marked difference in their ability to use C18:0 acyl-CoA as a substrate.
Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom. WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, United Kingdom. Biomedical Sciences Research Complex, Schools of Biology and Chemistry, University of St. Andrews, St. Andrews, Fife KY16 9ST, United Kingdom. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom; Luke.Chamberlain@strath.ac.uk. .
Related Products: order online
9: Title: Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization.
Authors: Murphy, Joseph, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 291 (44): 23036-23046, 2016 .
Snippet: Our results also suggest that zDHHC3, a palmitoyl acyltransferase (PAT), catalyzes the palmitoylation of PRCD in the Golgi compartment.
Affiliation: From the Department of Ophthalmology, West Virginia University Eye institute, Morgantown, West Virginia 26506. From the Department of Ophthalmology, West Virginia University Eye institute, Morgantown, West Virginia 26506 kolandaivelus@wvuhealthcare.com. .
Related Products: order online
10: Title: Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis.
Authors: Fang, Junshun, et.al. .
Journal: Biology of reproduction (Biol Reprod), Vol. 95 (3): 67, 2016 .
Snippet: Furthermore, we mapped ZDHHC3 palmitoylation sites in Gs alpha and showed that palmitoylation-deficient Gs alpha failed to arrest oocytes at G2.
Affiliation: State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China jianzhang84@genetics.ac.cn. State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China glxiachina@sohu.com. .
Related Products: order online
11: Title: ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.
Journal: Molecular and cellular biology (Mol Cell Biol), Vol. 36 (17): 2208-25, 2016 .
Snippet: Experiments with overexpression and pharmacological inhibition of FGF receptor (FGFR) and Src revealed that these kinases control tyrosine phosphorylation of ZDHHC3 and that ZDHHC3 is phosphorylated by endogenously expressed FGFR and Src proteins.
Affiliation: Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Verona, Italy. Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy St. Petersburg State University, St. Petersburg, Russia. Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy. Department of Cellular Neurophysiology, Hannover Medical School, Hannover, Germany. Department of Physiological Chemistry, Hannover Medical School, Hannover, Germany. Department of Cellular Neurophysiology, Hannover Medical School, Hannover, Germany ponimaskin.evgeni@mh-hannover.de alexander.dityatev@dzne.de. Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy Molecular Neuroplasticity Group, DZNE, Magdeburg, Germany Medical Faculty, Otto von Guericke University, Magdeburg, Germany Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany ponimaskin.evgeni@mh-hannover.de alexander.dityatev@dzne.de. .
Related Products: order online
12: Title: Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.
Authors: Ebersole, Brittany, et.al. .
Journal: PloS one, Vol. 10 (11): e0140661, 2015 .
Snippet: Co-immunoprecipitation analysis revealed that several other PATs, including zDHHC3 and zDHHC8, also interacted with the D2R and that each of the three PATs was capable of affecting the palmitoylation status of the D2R.
Affiliation: Department of Pharmacology, The Pennsylvania State College of Medicine, Hershey, Pennsylvania, United States of America. Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America. Center for Molecular Investigation of Neurological Disorders, The Pennsylvania State University, University Park, Pennsylvania, United States of America. .
Related Products: order online
13: Title: Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells.
Authors: Coleman, David T, et.al. .
Journal: PloS one, Vol. 10 (5): e0125399, 2015 .
Snippet: In the current study, we investigated the possibility that curcumin inhibits ITG β4 palmitoylation, a post-translational modification required for its lipid raft localization and signaling activity.
Affiliation: Department of Microbiology and FeistWeiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America. Department of Physiology and Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America; Department of Microbiology and FeistWeiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America. College of Pharmacy, Seoul National University, Seoul, South Korea. .
Related Products: order online
14: Title: The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity.
Authors: Lemonidis, Kimon, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 25 (24): 3870-83, 2014 .
Snippet: Despite this, zDHHC3/zDHHC7 could S-acylate SNAP25/CSP more efficiently than zDHHC17, whereas zDHHC13 lacked S-acylation activity toward these proteins.
Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom. ZMBP Developmental Genetics, D-72076 Tuebingen, Germany. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, United Kingdom Luke.Chamberlain@strath.ac.uk. .
Related Products: order online
15: Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Authors: Oku, Shinichiro, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 288 (27): 19816-29, 2013 .
Snippet: Of the 17 candidates, 10 proteins, including 6 synaptic proteins (Syd-1, transmembrane AMPA receptor regulatory protein (TARP) γ-2, TARP γ-8, cornichon-2, Ca(2+)/calmodulin-dependent protein kinase IIα, and neurochondrin (Ncdn)/norbin), one focal adhesion protein (zyxin), two ion channels (TRPM8 and TRPC1), and one G-protein-coupled receptor (orexin 2 receptor), were palmitoylated.
Affiliation: Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan. .
Related Products: order online
16: Title: Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis.
Authors: Greaves, Jennifer, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 287 (44): 37330-9, 2012 .
Snippet: Recently, mutations in the DNAJC5 gene encoding cysteine-string protein α (CSPα) were identified to cause the neurodegenerative disorder adult-onset neuronal ceroid lipofuscinosis.
Affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom. .
Related Products: order online
17: Title: Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner.
Authors: Lu, Dongmei, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 287 (26): 21856-65, 2012 .
Snippet: Overexpression of DHHC3 or DHHC7 increased PI4KIIα palmitoylation by >3-fold, whereas overexpression of the dominant-negative PATs or PAT silencing by RNA interference decreased PI4KIIα palmitoylation, "integral" membrane association, and Golgi localization.
Affiliation: Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. .
Related Products: order online
18: Title: Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin α6β4.
Authors: Sharma, Chandan, et.al. .
Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci), Vol. 69 (13): 2233-44, 2012 .
Snippet: Ablation of DHHC3 markedly diminished integrin-dependent cellular cable formation on Matrigel, integrin signaling through Src, and β4 phosphorylation on key diagnostic amino acids (S1356 and 1424).
Affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02215, USA. .
Related Products: order online
19: Title: Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.
Authors: Greaves, Jennifer, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 283 (36): 25014-26, 2008 .
Snippet: palmitoylation of CSP is enhanced specifically by co-expression of the Golgi-localized palmitoyl transferases DHHC3, DHHC7, DHHC15, or DHHC17
Affiliation: Centre for Integrative Physiology, School of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom. .
Related Products: order online
20: Title: [Localization of the NotI clones from human chromosome 3 on quail microchromosomes].
Authors: Kozyreva, A A, et.al. .
Journal: Genetika, Vol. 43 (6): 734-41, 2007 .
Snippet: At the same time, a suggestion on the localization of some orthologous genes in the genome of the organism under study was made: ARF4, SCN5A, PHF7, ABHD6, ZDHHC3, MAPKAPK3, ADSYNA (homolog of chicken chromosome 12), DRD2, PP2C-ETA, RAB7, CCKAR, and PKD1 (homolog of chicken chromosome 15).
Related Products: order online
Page 1 2 
Documents per page: 20 | 50 | 100