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20 documents found
1: Title: Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders.
Authors: Blaner, William S .
Journal: Pharmacology & therapeutics (Pharmacol Ther), 2019 .
Snippet: The primary focus of the review will be on the effects that vitamin A per se and proteins involved in vitamin A metabolism have on adipocytes, adipose tissue biology, and adipose-related disease, as well as on early stage liver disease, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
Affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032. Electronic address: wsb2@cumc.columbia.edu. .
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2: Title: Transcriptomic signature predicts the distant relapse in patients with ER+ breast cancer treated with tamoxifen for five years.
Authors: Zhou, Hao, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 17 (2): 3152-3157, 2018 .
Snippet: The expression levels of 10 genes were included in the model: CCNB2, CCNA2, FOXD1, WSB2, RBPMS, CTDSP1, BIN3, SLBP, EPRS, FTO.
Affiliation: Department of General Surgery, The First Affiliated Hospital of SooChow University, Suzhou, Jiangsu 215006, P.R. China. .
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3: Title: The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation.
Authors: Ayodele, Babatunde A, et.al. .
Journal: Bone reports (Bone Rep), Vol. 7, 2017 .
Snippet: Twelve genes (ATP6V0D2, BAK1, DDX5, GNB1, PIP4K2A, RAP1B, RPS7, SRSF3, SUB1, TMSB4, TPI1 and WSB2) were found to be more highly expressed in the zone of hypertrophic chondrocytes than in the reserve or proliferative zones, whereas FOXA3 and SERPINA1 were expressed at lower levels in the hypertrophic zone than in the reserve zone.
Affiliation: Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia. .
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4: Title: Acyl-CoA wax alcohol acyltransferase 2: its regulation and actions in support of color vision.
Journal: Journal of lipid research (J Lipid Res), Vol. 58 (4): 633-635, 2017 .
No Abstract available.
Affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032 wsb2@columbia.edu. .
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5: Title: Vitamin A Absorption, Storage and Mobilization.
Authors: Blaner, William S, et.al. .
Journal: Sub-cellular biochemistry (Subcell Biochem), Vol. 81, 2016 .
Snippet: It is well established that chylomicron remnant (dietary) vitamin A is taken up from the circulation by hepatocytes, but more than 80 % of the vitamin A in the liver is stored in hepatic stellate cells (HSC).
Affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, 650 W 168th St., New York, NY, 10032, USA. wsb2@columbia.edu. Department of Medicine, College of Physicians and Surgeons, Columbia University, 650 W 168th St., New York, NY, 10032, USA. .
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6: Title: Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice.
Authors: Lee, Seung-Ah, et.al. .
Journal: Hepatology (Baltimore, Md.) (Hepatology), Vol. 64 (5): 1534-1546, 2016 .
Snippet: We obtained no evidence that elevated hepatic triglyceride levels arise from increased hepatic de novo lipogenesis, decreased hepatic free fatty acid oxidation, or decreased very-low-density lipoprotein secretion.
Affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY. wsb2@cumc.columbia.edu. .
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7: Title: Lipocalin 2, a Regulator of Retinoid Homeostasis and Retinoid-mediated Thermogenic Activation in Adipose Tissue.
Authors: Guo, Hong, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 291 (21): 11216-29, 2016 .
Snippet: Lcn2 KO mice exhibited a blunted effect of all-trans-retinoic acid (ATRA) on body weight and fat mass, lipid metabolism, and retinoic acid signaling pathway activation in adipose tissue under the high fat diet-induced obese condition.
Affiliation: From the Departments of Food Science and Nutrition and. Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Twin Cities, Minnesota 55108 and. the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032. the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032 wsb2@columbia.edu. Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Twin Cities, Minnesota 55108 and BERNL001@umn.edu. From the Departments of Food Science and Nutrition and xlchen@umn.edu. .
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8: Title: Major Quantitative Trait Loci and Putative Candidate Genes for Powdery Mildew Resistance and Fruit-Related Traits Revealed by an Intraspecific Genetic Map for Watermelon (Citrullus lanatus var. lanatus).
Authors: Kim, Kwang-Hwan, et.al. .
Journal: PloS one, Vol. 10 (12): e0145665, 2015 .
Snippet: The ss2.1, located close to pmr2.1 and CAPS marker wsb2-13 (1.00 cM) on Chr02, explained 92.3% of the phenotypic variation (LOD = 68.78).
Affiliation: Department of Horticultural Bioscience, Pusan National University, Miryang, Republic of Korea. Department of Plant Science, Seoul National University, Seoul, Republic of Korea. Department of Genetics, University of Georgia, Athens, Georgia, United States of America. Partner Seed, Ansung, Republic of Korea. Department of Integrative Plant Science, College of Biotechnology and Natural Resources, Chung-Ang University, Ansung, Republic of Korea. Department of Plant Bioscience, Pusan National University, Miryang, Republic of Korea. Life and Industry Convergence Research Institute, Pusan National University, Miryang, Republic Korea. .
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9: Title: Evaluation of housekeeping genes for normalizing real-time quantitative PCR assays in pig skeletal muscle at multiple developmental stages.
Authors: Wang, Yueying, et.al. .
Journal: Gene, Vol. 565 (2): 235-41, 2015 .
Snippet: Our results indicated that DRAP1 and RNF7 were the most appropriate combination to normalize gene expression in the Yorkshire samples, the combination of DRAP1 and WSB2 were appropriate in the Tongcheng samples, H3F3A and DRAP1 in prenatal periods, DRAP1 and RNF7 in postnatal periods, and the combination of DRAP1 and WSB2 was most suitable for accurate normalization in whole samples.
Affiliation: Key Lab of Swine Genetics and Breeding of Ministry of Agriculture, Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong (Central China) Agricultural University, Wuhan, Hubei, PR China. Department of Animal Science, Michigan State University, East Lansing, MI, United States. China Education Ministry's Key Laboratory in Agricultural Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China. Key Lab of Swine Genetics and Breeding of Ministry of Agriculture, Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong (Central China) Agricultural University, Wuhan, Hubei, PR China. Electronic address: leimg@mail.hzau.edu.cn. .
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10: Title: Actions of β-apo-carotenoids in differentiating cells: differential effects in P19 cells and 3T3-L1 adipocytes.
Authors: Wang, Cynthia X, et.al. .
Journal: Archives of biochemistry and biophysics (Arch Biochem Biophys), Vol. 572, 2015 .
Snippet: We also investigated the effects of two β-apo-carotenoids on 3T3-L1 adipocyte marker gene expression during adipocyte differentiation.
Affiliation: Columbia College, Columbia University, New York, NY 10032, United States. College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States. College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States; Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, United States. College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States. Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, United States. College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States. Electronic address: wsb2@columbia.edu. .
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11: Title: Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.
Authors: Brun, Pierre-Jacques, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 29 (2): 671-83, 2015 .
Snippet: atRA signaling was ablated in β-cells by overexpressing a dominant-negative retinoic acid receptor (RAR)-α mutant (RARdn) using an inducible Cre-Lox system under the control of the pancreas duodenal homeobox gene promoter.
Affiliation: Departments of *Medicine and Pediatrics and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY USA; Department of Medicine, The University of Kansas Medical Center, Kansas City, KS, USA; Research Foundation Itsuu Laboratory, Tokyo, Japan; and Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan. Departments of *Medicine and Pediatrics and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY USA; Department of Medicine, The University of Kansas Medical Center, Kansas City, KS, USA; Research Foundation Itsuu Laboratory, Tokyo, Japan; and Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan wsb2@columbia.edu. .
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12: Title: Cardiac dysfunction in β-carotene-15,15'-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism.
Authors: Lee, Seung-Ah, et.al. .
Journal: American journal of physiology. Heart and circulatory physiology (Am J Physiol Heart Circ Physiol), Vol. 307 (11): H1675-84, 2014 .
Snippet: These lipid changes were accompanied by elevations in levels of genes important to retinoid metabolism, specifically retinol dehydrogenase 10 and retinol-binding protein 4, as well as genes involved in lipid metabolism, including peroxisome proliferator-activated receptor-γ, lipoprotein lipase, Cd36, stearoyl-CoA desaturase 1, and fatty acid synthase.
Affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York; College of Pharmacy, The Ohio State University, Columbus, Ohio; and Department of Human Nutrition, The Ohio State University, Columbus, Ohio. College of Pharmacy, The Ohio State University, Columbus, Ohio; and. Department of Human Nutrition, The Ohio State University, Columbus, Ohio. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York; wsb2@columbia.edu. .
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13: Title: Differential oncogene-related gene expressions in myeloma cells resistant to prednisone and vincristine.
Authors: Mutlu, Pelin, et.al. .
Journal: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie (Biomed Pharmacother), Vol. 66 (7): 506-11, 2012 .
Snippet: Different types of interleukin gene expressions were seen to be altered in resistant MM sublines whereas suppressors of cytokine signalling genes such as SOCS2, SOCS4 and WSB2 were all downregulated.
Affiliation: Middle East Technical University, Central Laboratory, Molecular Biology and Biotechnology R&D Center, Ankara, Turkey. pelinkaya78@yahoo.com .
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14: Title: The cardiovascular response to underwater pedaling at different intensities: a comparison of 4 different water stationary bikes.
Authors: Giacomini, F, et.al. .
Journal: The Journal of sports medicine and physical fitness (J Sport Med Phys Fit), Vol. 49 (4): 432-9, 2009 .
Snippet: Sixteen of them, 8 males (age 31.5 + or - 8.2 years) and 8 females (age 31.9 + or - 5.8 years) with the same level of peak oxygen consumption (VO(2peak)) were chosen and submitted, in random order, to four incremental testing sessions performed with four different models of WSB, one with no resistance (WSB1), two with resistance added to the bottom bracket axle (WSB2 and WSB3), one with resistance added to the pedals (WSB4).
Affiliation: Istituto di Ricerca sull'Attività Motoria, Carlo Bo University of Urbino, Urbino, Italy. .
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15: Title: Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage.
Authors: Blaner, William S, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1791 (6): 467-73, 2009 .
Snippet: The majority of retinoid (vitamin A and its metabolites) present in the body of a healthy vertebrate is contained within lipid droplets present in the cytoplasm of hepatic stellate cells (HSCs).
Affiliation: Department of Medicine, Columbia University, 630 W. 168th St., New York, NY 10032, USA. wsb2@columbia.edu .
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16: Title: Retinoids and the metabolic syndrome.
Authors: O'Byrne, Sheila M, et.al. .
Journal: Expert review of endocrinology & metabolism (Expert Rev Endocrinol Metab), Vol. 3 (5): 539-541, 2008 .
No Abstract available.
Affiliation: a Division of Preventive Medicine and Nutrition, Department of Medicine, College of Physicians and Surgeons, Columbia University, 650 West 168th Street, New York, NY 10032, USA. so2017@columbia.edu. b Division of Preventive Medicine and Nutrition, Department of Medicine, College of Physicians and Surgeons, Columbia University, 650 West 168th Street, New York, NY 10032, USA. wsb2@columbia.edu. .
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17: Title: Retinoid inactivation: survival factor for male germ cells.
Authors: Blaner, William S, et.al. .
Journal: Endocrinology, Vol. 148 (10): 4557-9, 2007 .
No Abstract available.
Affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA. wsb2@columbia.edu .
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18: Title: Expression of Wsb2 in the developing and adult mouse testis.
Authors: Sarraj, M A, et.al. .
Journal: Reproduction (Cambridge, England) (Reproduction), Vol. 133 (4): 753-61, 2007 .
Snippet: Real-time analysis of adult mouse testis tubules cultured in the presence of the Hedgehog signalling inhibitor, cyclopamine, showed a downregulation of Wsb2 mRNA after treatment which suggests that Wsb2 may be a target of Hedgehog signalling.
Affiliation: The ARC Centre of Excellence in Biotechnology and Development, Murdoch Children's Research Institute and the Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria, Australia. .
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19: Title: STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens.
Journal: Cell metabolism (Cell Metab), Vol. 5 (3): 164-6, 2007 .
Snippet: How retinol (vitamin A) is taken up by cells has been an area of active research since the first report of a cell-surface receptor for retinol-binding protein (RBP) in the mid-1970s.
Affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. wsb2@columbia.edu .
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20: Title: Cellular metabolism and actions of 13-cis-retinoic acid.
Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol), Vol. 45 (5): S129-35, 2001 .
Snippet: The gene regulatory activities of retinoids are mediated primarily by the all-trans and 9-cis isomers of retinoic acid.
Affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, 701 W 168th St., New York, NY 10032, USA. wsb2@columbia.edu .
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