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34 documents found
1: Title: WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer.
Authors: Poujade, Flore-Anne, et.al. .
Journal: British journal of cancer (Br J Cancer), 2018 .
Snippet: In silico analyses were used to determine the impact of WSB-1 expression on distant metastasis-free survival (DMFS) in patients, and correlation between WSB1 expression and hypoxia gene expression signatures.
Affiliation: School of Life Sciences, University of Hull, Hull, UK. Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, The University of Oxford, Oxford, UK. Positron Emission Tomography Research Centre, University of Hull, Hull, UK. School of Life Sciences, University of Hull, Hull, UK. i.pires@hull.ac.uk. .
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2: Title: Biallelic Dicer1 loss mediated by aP2-Cre drives angiosarcoma.
Authors: Hanna, Jason A, et.al. .
Journal: Cancer research (Cancer Res), 2017 .
Snippet: MicroRNA-23 target genes including the oncogenes Ccnd1 as well as Adam19, Plau, and Wsb1 that promote invasiveness and metastasis were enriched in mouse and human angiosarcoma.
Affiliation: Oncology, St. Jude Children's Research Hospital. Computational Biology, St. Jude Children's Research Hospital. Dept of Pathology, St Jude Children's Research Hosp. Oncology, St. Jude Children's Research Hospital mark.hatley@stjude.org. .
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3: Title: Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer.
Authors: Chen, Meng-Chuan, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 5376, 2017 .
Snippet: Treatment with AE-AS markedly decreased the protein accumulation and transcriptional activity of HIF-1α, vascular endothelial growth factor (VEGF) expression/secretion, and VEGFR2 phosphorylation in hypoxic human bladder cancer (T24) cells and tumor tissues accompanied by a reduction of tumor growth.
Affiliation: School of Dentistry, Graduated Institute of Dental Science, National Defense Medical Center, Taipei, Taiwan. School of Medicine, Tzu Chi University, Hualien, Taiwan. Department of Radiation Oncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. chou195966@gmail.com. Department of Biotechnology, Asia University, Taichung, Taiwan. chou195966@gmail.com. China Medical University Hospital, China Medical University, Taichung, Taiwan. chou195966@gmail.com. .
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4: Title: WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation.
Authors: Kim, Jung Jin, et.al. .
Journal: Cell research (Cell Res), Vol. 27 (2): 274-293, 2017 .
Snippet: Here, we show that the E3 ubiquitin ligase WD repeat and SOCS box-containing protein 1 (WSB1) plays a role in overcoming OIS.
Affiliation: Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA. Department of Medical Education, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon 404834, Republic of Korea. Department of Surgery, School of Medicine, Kyung Hee University, Seoul 130872, Republic of Korea. Department of Family Medicine, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon 404834, Republic of Korea. Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul 130872, Republic of Korea. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. .
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5: Title: WSB1: from homeostasis to hypoxia.
Authors: Haque, Moinul, et.al. .
Journal: Journal of biomedical science (J Biomed Sci), Vol. 23 (1): 61, 2016 .
Snippet: The major expressed isoform, WSB1 protein, is a substrate recognition protein within an E3 ubiquitin ligase, with the capability to bind diverse targets and mediate ubiquitinylation and proteolytic degradation.
Affiliation: Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. Department of Oncology, University of Calgary, Calgary, AB, T2N 4N1, Canada. Department of Medical Biochemistry, University of Calgary, Calgary, AB, T2N 4N1, Canada. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. demetric@ucalgary.ca. Department of Oncology, University of Calgary, Calgary, AB, T2N 4N1, Canada. demetric@ucalgary.ca. Department of Medical Biochemistry, University of Calgary, Calgary, AB, T2N 4N1, Canada. demetric@ucalgary.ca. Calgary Laboratory Services, Room 302, HMRB, 3330 Hospital Dr. N.W., Calgary, AB, T2N 4N1, Canada. demetric@ucalgary.ca. .
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6: Title: Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.
Journal: Nature communications (Nat Commun), Vol. 7, 2016 .
Snippet: WSB1 ubiquitinates LRRK2 through K27 and K29 linkage chains, leading to LRRK2 aggregation and neuronal protection in primary neurons and a Drosophila model of G2019S LRRK2.
Affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. Danone Nutricia Research, 30 Biopolis Street, Matrix Building, #05-01B, Singapore 138671, Singapore. Department of Molecular Pharmacology, Rappaport Institute of Medical Research, Technion-Israel Institute of Technology, Haifa 31096, Israel. Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA. Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA. Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA. Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA. Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685, USA. Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore. Department of Physiology, National University of Singapore, Singapore 117543, Singapore. .
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7: Title: miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth.
Authors: Jia, Yan-Yan, et.al. .
Journal: Oncotarget, Vol. 7 (23): 35257-69, 2016 .
Snippet: We further showed that miR-592 directly binds to the 3'-UTR of the WSB1 gene, thus disrupting hypoxia inducible factor-1α (HIF-1α) protein stabilization.
Affiliation: Department of Pharmacy, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, Guangdong, P. R. China. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, P. R. China. Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, P. R. China. .
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8: Title: Analysis of miRNA in Normal Appearing White Matter to Identify Altered CNS Pathways in Multiple Sclerosis.
Journal: Journal of autoimmune disorders (Unknown Journal), Vol. 1 (1), 2015 .
Snippet: Using target predication and mRNA analysis, an inverse relationship was found between miR-191 and BDNF, SOX4, FZD5 and WSB1.
Affiliation: Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Biomedical Sciences Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Department of Neurology, Yale School of Medicine, New Haven, CT.; Department of Neurology, The Ohio State University Wexner MedicalCenter, Columbus, OH, USA. Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Neurology, The Ohio State University Wexner MedicalCenter, Columbus, OH, USA. Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA. .
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9: Title: WSB1 promotes tumor metastasis by inducing pVHL degradation.
Authors: Kim, Jung Jin, et.al. .
Journal: Genes & development (Genes Dev), Vol. 29 (21): 2244-57, 2015 .
Snippet: Here we show that WD repeat and SOCS box-containing protein 1 (WSB1) is a negative regulator of pVHL through WSB1's E3 ligase activity.
Affiliation: Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA; Division of Pulmonary and Critical Care Medicine, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA; Department of Pathology, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon 404-834, Republic of Korea; Department of Family Medicine, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon 404-834, Republic of Korea; Department of Surgery, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA; Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA; Mayo Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA; Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, Republic of Korea; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA. .
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10: Title: Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells.
Authors: Cao, Ji, et.al. .
Journal: Cancer research (Cancer Res), Vol. 75 (22): 4839-51, 2015 .
Snippet: Quantitative proteomic and functional analyses revealed that WSB1 ubiquitylates the Rho-binding protein RhoGDI2 and promotes its proteasomal degradation, thereby activating Rac1 to stimulate tumor cell motility and invasion.
Affiliation: Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China. Zhejiang Province Key Laboratory of Medical Molecular Imaging, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China. Institute for Individualized Medicine, Hangzhou First People's Hospital, Hangzhou, China. Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand. Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. yang924@zju.edu.cn. .
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11: Title: Multiplex Ligation-dependent Probe Amplification Can Clarify HER2 Status in Gastric Cancers with "Polysomy 17".
Authors: Wang, Tao, et.al. .
Journal: Journal of Cancer (J Cancer), Vol. 6 (5): 403-8, 2015 .
Snippet: Overall, 9 of 13 polyCEP17 cases had amplification of the peri-centromeric gene WSB1, compared to 1 of 8 non-polyCEP17 controls (p=0.02).
Affiliation: 1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; 2. Genomics Core Facilities, Sunnybrook Research Institute, Toronto, Canada; 1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; ; 3. Department of Pathology, Toronto East General Hospital, Toronto, Canada; 1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; ; 2. Genomics Core Facilities, Sunnybrook Research Institute, Toronto, Canada; ; 4. Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, Canada. 1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; ; 4. Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, Canada. .
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12: Title: Identification of Target Genes Regulated by KSHV miRNAs in KSHV-Infected Lymphoma Cells.
Authors: Quan, Liangliang, et.al. .
Journal: Pathology oncology research : POR (Pathol Oncol Res), Vol. 21 (4): 875-80, 2015 .
Snippet: Totally, 7 KSHV-related genes regulated by KSHV miRNAs were identified, including IPO5, EDA, NT5C3, WSB1, KCNS1, PRAM1 and MTRNR2L6.
Affiliation: Department of Plastic Surgery, General Hospital of Shenyang Military Area Command, PLA, No. 83 Wenhua Road, Shenhe District, Shenyang, 110016, Liaoning Province, China. .
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13: Title: Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.
Journal: The Journal of clinical investigation (J Clin Invest), Vol. 125 (2): 769-81, 2015 .
Snippet: In vivo studies in mice harboring an astrocyte-specific Wsb1 deletion as well as in vitro analysis of D2 ubiquitination driven by different tissue extracts indicated that D2 ubiquitination in the hypothalamus is relatively less.
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14: Title: Minimal requirements for ubiquitination-mediated regulation of thyroid hormone activation.
Authors: Egri, Péter, et.al. .
Journal: Journal of molecular endocrinology (J Mol Endocrinol), Vol. 53 (2): 217-26, 2014 .
Snippet: In conclusion, insertion of the instability loop and ubiquitin carrier lysines in combination with direction to the ER are sufficient and required to govern WSB1-mediated ubiquitination of an activating deiodinase enzyme.
Affiliation: Department of Endocrine NeurobiologyInstitute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, Budapest H-1083, HungaryJános Szentágothai PhD School of NeurosciencesSemmelweis University, Budapest H-1085, Hungary Department of Endocrine NeurobiologyInstitute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, Budapest H-1083, HungaryJános Szentágothai PhD School of NeurosciencesSemmelweis University, Budapest H-1085, Hungary. Department of Endocrine NeurobiologyInstitute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, Budapest H-1083, HungaryJános Szentágothai PhD School of NeurosciencesSemmelweis University, Budapest H-1085, Hungary gereben.balazs@koki.mta.hu. .
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15: Title: Potential role of WSB1 isoforms in growth and survival of neuroblastoma cells.
Authors: Shichrur, Keren, et.al. .
Journal: Pediatric research (Pediatr Res), Vol. 75 (4): 482-6, 2014 .
Snippet: Effective WSB1 small interfering RNAs were transfected into cultured NB cell lines, and cell viability was analyzed using XTT assay and flow cytometry.
Affiliation: 1] Molecular Oncology, Felsenstein Medical Research Center, Petah Tikva, Israel [2] Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Pediatric Hematology Oncology Center, Schneider Children's Medical Center of Israel, Petah Tikva, Israel. 1] Molecular Oncology, Felsenstein Medical Research Center, Petah Tikva, Israel [2] Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel [3] Pediatric Hematology Oncology Center, Schneider Children's Medical Center of Israel, Petah Tikva, Israel. .
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16: Title: HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells.
Authors: Tong, Ying, et.al. .
Journal: FEBS letters (Febs Lett), Vol. 587 (16): 2530-5, 2013 .
Snippet: WSB-1 is involved in DNA damage response by targeting homeodomain-interacting protein kinase 2 (HIPK2) for ubiquitination and degradation.
Affiliation: Department of Liver Surgery, Renji Hospital, Medical College of Shanghai Jiaotong University, China. .
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17: Title: A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
Authors: Kim, Dong Hwan Dennis, et.al. .
Journal: Blood, Vol. 117 (25): 6906-11, 2011 .
Snippet: Candidate genes in those regions include RMND1, AKAP12, ZBTB2, and WSB1.
Affiliation: Department of Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. .
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18: Title: Identification of a novel candidate gene for non-syndromic autosomal recessive intellectual disability: the WASH complex member SWIP.
Authors: Ropers, Fabienne, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 20 (13): 2585-90, 2011 .
Snippet: After appropriate single-nucleotide polymorphism filtering, only two molecular changes remained, including a non-synonymous sequence change in the SWIP [Strumpellin and WASH (Wiskott-Aldrich syndrome protein and scar homolog)-interacting protein] gene, a member of the recently discovered WASH complex, which is involved in actin polymerization and multiple endosomal transport processes.
Affiliation: Department of Pediatrics and Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburgerplatz 1, Berlin, Germany. fabienne.ropers@charite.de .
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19: Title: WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor.
Authors: Nara, Hidetoshi, et.al. .
Journal: Cellular immunology (Cell Immunol), Vol. 269 (1): 54-9, 2011 .
Snippet: IL-21 binds with its cognate receptor complex, which consists of the IL-21 receptor (IL-21R) and the common gamma chain.
Affiliation: Department of Immunology, Yamagata University, Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. .
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20: Title: Differential regulation of proliferation, cell cycle control and gene expression in cultured human aortic and pulmonary artery endothelial cells by resveratrol.
Authors: Hsieh, Tze-Chen, et.al. .
Journal: International journal of molecular medicine (Int J Mol Med), Vol. 26 (5): 743-9, 2010 .
Snippet: In addition, treatment by resveratrol also resulted in attenuated expression of bcl-xl, fibronectin-1, HIP, mdm2, PIG3 and WSB1/SWIP-1 in HAECs, and CDX1, engrailed homolog 1, FASN, fibronectin-1, forkhead box A2, Hoxa-1, hsp27, PIG3, ELAM-1/E-selectin and WSB1/SWIP-1 in HPAECs.
Affiliation: Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA. .
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