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42 documents found
1: Title: Elevated expression of NFE2L3 predicts the poor prognosis of pancreatic cancer patients.
Authors: Wang, Hui, et.al. .
Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle), Vol. 17 (17): 2164-2174, 2018 .
Snippet: ABBREVIATIONS: NFE2L3: NF-E2-related factor 3; UHMK1: U2AF homology motif kinase 1; VEGFA: vascular endothelial growth factor A; GEO: gene expression omnibus; TCGA: The Cancer Genome Atlas; HPDE: human pancreas duct cells; OS: overall survival; IHC: immunohistochemistry; FFPE: formalin-fixed and paraffin-embedded; SEM: standard error of mean.
Affiliation: a Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai , China. b The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital , Shanghai Jiaotong University School of Medicine , Shanghai , China. c Department of Pathology, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai , China. .
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2: Title: Molecular pathogenesis of pancreatic ductal adenocarcinoma: impact of passenger strand of pre-miR-148a on gene regulation.
Authors: Idichi, Tetsuya, et.al. .
Journal: Cancer science (Cancer Sci), 2018 .
Snippet: High expression of miR-148a-5p targets (PHLDA2, LPCAT2 and AP1S3) and miR-148a-3p targets (SMA, ENDOD1 and UHMK1) was associated with poor prognosis of patients with PDAC.
Affiliation: Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, Kagoshima, Japan. Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan. .
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3: Title: The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation.
Authors: Barbutti, Isabella, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1864 (3): 959-966, 2018 .
Snippet: UHMK1 (KIS) is a nuclear serine/threonine kinase that possesses a U2AF homology motif and phosphorylates and regulates the activity of the splicing factors SF1 and SF3b155.
Affiliation: Hematology and Transfusion Medicine Center, State University of Campinas (UNICAMP), Carlos Chagas 480, 13083-878 Campinas, SP, Brazil. Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Hematology and Transfusion Medicine Center, State University of Campinas (UNICAMP), Carlos Chagas 480, 13083-878 Campinas, SP, Brazil; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address: leticiafa@fmrp.usp.br. .
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4: Title: Exome-Wide Association Study of Pancreatic Cancer Risk.
Authors: Grant, Robert C, et.al. .
Journal: Gastroenterology, 2017 .
Snippet: 6 genes were enriched for rare damaging variants (UHMK1, AP1G2, DNTA, CHST6, FGFR3, and EPHA1) and 7 genes had associations with pancreatic cancer risk, based on the sequence-kernel association test.
Affiliation: Ontario Institute for Cancer Research, Toronto, Canada. Ontario Pancreas Cancer Study, Toronto, Canada. Princess Margaret Genomics Centre, Toronto, Canada. Research Institute of the McGill University Health Centre, Montreal, Canada. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland. Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland. Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom. Ontario Institute for Cancer Research, Toronto, Canada; Ontario Pancreas Cancer Study, Toronto, Canada. Ontario Institute for Cancer Research, Toronto, Canada; Ontario Pancreas Cancer Study, Toronto, Canada. Electronic address: steven.gallinger@uhn.ca. .
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5: Title: Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 12494, 2017 .
Snippet: Finally, NRF3 mediates gene expression of the cell cycle regulator U2AF homology motif kinase 1 (UHMK1) for cell proliferation.
Affiliation: Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan. Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan. National Institutes of Advanced Industrial Science and Technology, Biological Information Research Center (JBIRC), Tokyo, Japan. Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan. akobayas@mail.doshisha.ac.jp. .
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6: Title: Systematic review: Tumor-associated antigen autoantibodies and ovarian cancer early detection.
Journal: Gynecologic oncology (Gynecol Oncol), 2017 .
Snippet: A panel of 11 AAbs (ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3) provided 45% sensitivity at 98% specificity for serous ovarian cancer, when at least 2 AAbs were above a threshold of 95% specificity.
Affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany. Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany. Electronic address: r.kaaks@dkfz.de. .
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7: Title: Autoantibody biomarkers for the detection of serous ovarian cancer.
Authors: Katchman, Benjamin A, et.al. .
Journal: Gynecologic oncology (Gynecol Oncol), Vol. 146 (1): 129-136, 2017 .
Snippet: RESULTS: We identified 11-TAAbs (ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3) that distinguished high-grade serous ovarian cancer cases from healthy controls with a combined 45% sensitivity at 98% specificity.
Affiliation: Virginia G. Piper Center for Personal Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA. Department of Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA. Virginia G. Piper Center for Personal Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA. Electronic address: Karen.Anderson.1@asu.edu. .
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8: Title: Erratum to "Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility" [Bone 91 (2016) 113-121].
Authors: Choi, Hyung Jin, et.al. .
Journal: Bone, Vol. 97, 2017 .
No Abstract available.
Affiliation: Department of Anatomy, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China. Department of Epidemiology, School of Public Health, Soochow University, Jiangsu, PR China. Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, USA. Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Cheongju, Republic of Korea. Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address: chnaha@ajou.ac.kr. .
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9: Title: SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA.
Authors: Chatrikhi, Rakesh, et.al. .
Journal: Biophysical journal (Biophys J), Vol. 111 (12): 2570-2586, 2016 .
Snippet: Here, we use isothermal titration calorimetry to demonstrate that UHMK1 phosphorylation of the SF1 SPSP motif slightly enhances specific binding of phospho-SF1 to its cognate U2AF(65) protein partner.
Affiliation: Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York. Université d'Evry-Val-d'Essonne, Evry Cedex, France. Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York. Electronic address: clara_kielkopf@urmc.rochester.edu. .
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10: Title: Corrigendum to genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene.
Authors: Choi, Hyung Jin, et.al. .
Journal: Bone, 2016 .
No Abstract available.
Affiliation: Department of Anatomy, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China. Department of Epidemiology, School of Public Health, Soochow University, Jiangsu, PR China. Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, USA. Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Cheongju, Republic of Korea. Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address: chnaha@ajou.ac.kr. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: csshin@snu.ac.kr. .
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11: Title: Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene.
Authors: Choi, Hyung Jin, et.al. .
Journal: Bone, Vol. 91, 2016 .
Snippet: Functional studies suggest a role of UHMK1 on regulation of osteoblasts and osteoclasts.
Affiliation: Department of Anatomy, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Center for Genetic Epidemiology and Genomics, School of Public Health, Soochow University, Jiangsu, PR China. Department of Epidemiology, School of Public Health, Soochow University, Jiangsu, PR China. Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, USA. Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Cheongju, Republic of Korea. Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address: chnaha@ajou.ac.kr. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: csshin@snu.ac.kr. .
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12: Title: Candidate gene networks and blood biomarkers of methamphetamine-associated psychosis: an integrative RNA-sequencing report.
Authors: Breen, M S, et.al. .
Journal: Translational psychiatry (Transl Psychiatr), Vol. 6, 2016 .
Snippet: CFG evidence validated a significant proportion of these putative MAP biomarkers in independent studies including CLN3, FBP1, TBC1D2 and ZNF821 (RNA degradation), ELK3 and SINA3 (circadian clock) and PIGF and UHMK1 (ubiquitin-mediated proteolysis).
Affiliation: Department of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. Department of Psychiatry and MRC Unit on Anxiety and Stress Disorders, Groote Schuur Hospital (J-2), University of Cape Town, Cape Town, South Africa. Department of Molecular and Cellular Biology, University of Cape Town, Cape Town, South Africa. Psychiatric Genetic Epidemiology and Neurobiology Laboratory, Departments of Psychiatry and Behavioral Sciences and Neuroscience and Physiology, Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, NY, USA. The Estonian Genome Center, University of Tartu, Tartu, Estonia. .
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13: Title: Novel genetic causes for cerebral visual impairment.
Authors: Bosch, Daniëlle G M, et.al. .
Journal: European journal of human genetics : EJHG (Eur J Hum Genet), Vol. 24 (5): 660-5, 2016 .
Snippet: In addition, in 11 patients (44%) with CVI, variants in one or more candidate genes were identified (ACP6, AMOT, ARHGEF10L, ATP6V1A, DCAF6, DLG4, GABRB2, GRIN1, GRIN2B, KCNQ3, KCTD19, RERE, SLC1A1, SLC25A16, SLC35A2, SOX5, UFSP2, UHMK1, ZFP30).
Affiliation: Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands. Bartiméus Institute for the Visually Impaired, Zeist, The Netherlands. Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands. Hubrecht Institute-KNAW, University Medical Centre Utrecht, CancerGenomics.nl, Utrecht, The Netherlands. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Texas Children's Hospital, Houston, TX, USA. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. .
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14: Title: Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation.
Authors: Chen, Xu, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Mechanistically, WDR5 regulated various functions in bladder cancer by mediating the transcription of cyclin B1, cyclin E1, cyclin E2, UHMK1, MCL1, BIRC3 and Nanog by histone H3 lysine 4 trimethylation.
Affiliation: 1] Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China [2] Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Department of Internal Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. .
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15: Title: KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling.
Authors: Pedraza, Neus, et.al. .
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), Vol. 34 (42): 13988-97, 2014 .
Snippet: Our study provides insights into the mechanisms that mediate dendritic spine morphogenesis and functional synaptic maturation, and suggests KIS as a link regulating spine cytoskeleton and postsynaptic activity in memory formation.
Affiliation: Molecular Biology Institute of Barcelona (IBMB-CSIC), 08028 Barcelona, Catalonia, Spain and. Laboratory of Neurobiology, Bellvitge Biomedical Research Institute (IDIBELL) and University of Barcelona, 08907 L'Hospitalet de Llobregat, Spain. Molecular Biology Institute of Barcelona (IBMB-CSIC), 08028 Barcelona, Catalonia, Spain and cggbmc@ibmb.csic.es. .
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16: Title: The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS).
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1833 (5): 1269-79, 2013 .
Snippet: Using CATS as a bait in a yeast two-hybrid screen we identified the Kinase Interacting Stathmin (KIS or UHMK1) protein as a CATS interacting partner.
Affiliation: Hematology and Hemotherapy Center, State University of Campinas, Campinas, Brazil. leticiaf@unicamp.br .
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17: Title: The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.
Authors: Manceau, Valérie, et.al. .
Journal: PloS one, Vol. 7 (8): e43946, 2012 .
Snippet: The brain-enriched protein kinase KIS (product of the gene UHMK1) has been shown to phosphorylate the human splicing factor SF1 in vitro.
Affiliation: INSERM, UMR-S 839, Paris, France. .
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18: Title: A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia.
Authors: Rizig, Mie A, et.al. .
Journal: Journal of psychopharmacology (Oxford, England) (J Psychopharmacol), Vol. 26 (9): 1218-30, 2012 .
Snippet: Several genes implicated genetically or functionally in schizophrenia such as frizzled homolog 3 (FZD3), U2AF homology motif kinase 1 (UHMK1), pericentriolar material 1 (PCM1) and brain-derived neurotrophic factor (BDNF) were changed by clozapine but not by haloperidol.
Affiliation: Molecular Psychiatry Laboratory, University College London, London, UK. .
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19: Title: Genetic and molecular exploration of UHMK1 in schizophrenic patients.
Authors: Dumaine, Anne, et.al. .
Journal: Psychiatric genetics (Psychiatr Genet), Vol. 21 (6): 315-8, 2011 .
Snippet: In two recent papers, polymorphisms located in U2AF homology motif kinase 1 (UHMK1) gene have been associated to schizophrenia.
Affiliation: Psychiatrie Génétique, Hôpital Henri Mondor, France. .
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20: Title: Cord blood administration induces oligodendrocyte survival through alterations in gene expression.
Authors: Rowe, D D, et.al. .
Journal: Brain research (Brain Res), Vol. 1366, 2010 .
Snippet: The microarray results were verified using quantitative RT-PCR for the following eight genes: U2AF homology motif kinase 1 (Uhmk1), insulin-induced gene 1 (Insig1), metallothionein 3 (Mt3), tetraspanin 2 (Tspan2), peroxiredoxin 4 (Prdx4), stathmin-like 2 (Stmn2), myelin oligodendrocyte glycoprotein (MOG), and versican (Vcan).
Affiliation: Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA. drowe@health.usf.edu .
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