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47 documents found
1: Title: TSPAN7 promotes the migration and proliferation of lung cancer cells via epithelial-to-mesenchymal transition.
Authors: Wang, Xianguo, et.al. .
Journal: OncoTargets and therapy (Onco Targets Ther), Vol. 11, 2018 .
Snippet: Results: Our clinical data showed that among 125 patients with lung cancer, TSPAN7 was associated with lymph node status, differentiation, tumor size, and poor prognosis.
Affiliation: Thoracic and Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan, Hubei 430071, China, zrsearch@sohu.com. Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. .
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2: Title: Survival of a Male Infant with a Familial Xp11.4 Deletion Causing Ornithine Transcarbamylase Deficiency.
Authors: McPheron, Molly, et.al. .
Journal: JIMD reports (Jimd Rep), Vol. 45, 2019 .
Snippet: We describe two male newborns and their mother who all have a 1.5-Mb deletion of Xp11.4 encompassing the genes TSPAN7, OTC, and part of RPGR.
Affiliation: Indiana University School of Medicine, Indianapolis, IN, USA. mmcphero@iupui.edu. Indiana University School of Medicine, Indianapolis, IN, USA. .
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3: Title: Tetraspanin Assemblies in Virus Infection.
Authors: Florin, Luise, et.al. .
Journal: Frontiers in immunology (Front Immunol), Vol. 9, 2018 .
Snippet: It appears that Tspans, such as CD151, CD82, CD81, CD63, CD9, Tspan9, and Tspan7, coordinate these associations by concentrating the interacting partners into Tspan platforms.
Affiliation: Department of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. Department of Membrane Biochemistry, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany. .
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4: Title: Assessment of de novo copy-number variations in Italian patients with schizophrenia: Detection of putative mutations involving regulatory enhancer elements.
Authors: Piluso, Giulio, et.al. .
Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (World J Biol Psychiatry), 2017 .
Snippet: De novo CNVs encompass genes (CNTNAP2, MAGI1, TSPAN7 and MET) involved in brain development, while that involving the enhancer element hs1043, also includes ZIC1, which plays a role in neural development and is responsible of behavioural abnormalities in Zic mutant mice.
Affiliation: a Department of Biochemistry, Biophysics and General Pathology , University of Campania "Luigi Vanvitelli" , Naples , Italy. b Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Section of Neuroscience , University of Salerno , Salerno , Italy. c Department of Psychiatry , University of Campania "Luigi Vanvitelli" , Naples , Italy. d Department of Neurological and Psychiatric Sciences , University of Bari , Bari , Italy. e Department of Neuroscience, Section of Psychiatry , University of Turin , Turin , Italy. f Department of Biotechnological and Applied Clinical Sciences, Section of Psychiatry , University of L'Aquila , L'Aquila , Italy. g Department of Clinical and Molecular Biomedicine, Psychiatry Unit , University of Catania , Catania , Italy. h Department of Medical Sciences, Psychiatry Unit , University of Foggia , Foggia , Italy. i Department of Neurosciences, Mental Health and Sensory Organs , S. Andrea Hospital, Sapienza University of Rome , Rome , Italy. j Department of Neuroscience and Imaging, Chair of Psychiatry , G. D'Annunzio University , Chieti , Italy. k Department of Molecular Medicine and Clinical Department of Mental Health , University of Siena , Siena , Italy. l Department of Neuroscience, Psychiatry Unit , University of Parma , Parma , Italy. m Department of Life, Health and Environmental Sciences, Unit of Psychiatry , University of L'Aquila , L'Aquila , Italy. n Psychiatric Unit, School of Medicine, Department of Mental Health , University of Brescia and Spedali Civili Hospital , Brescia , Italy. o Psychiatric Clinic, Department of Neurosciences , University of Padua , Padua , Italy. p Department of Systems Medicine, Chair of Psychiatry , Tor Vergata University of Rome , Rome , Italy. q Department of Psychiatry , University of Perugia , Perugia , Italy. .
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5: Title: Chromosomal Context Affects the Molecular Evolution of Sex-linked Genes and Their Autosomal Counterparts in Turtles and Other Vertebrates.
Authors: Radhakrishnan, Srihari, et.al. .
Journal: The Journal of heredity (J Hered), Vol. 108 (7): 720-730, 2017 .
Snippet: Notably, results revealed a putative selective sweep around two turtle genes involved in vertebrate gonadogenesis (Pelodiscus-Z-linked Nf2 and Chrysemys-autosomal Tspan7).
Affiliation: Bioinformatics and Computational Biology Program, Iowa State University, Ames, IA 50011. Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA 50011. .
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6: Title: Pharmacological Modulation of AMPAR Rescues Intellectual Disability-Like Phenotype in Tm4sf2-/y Mice.
Authors: Murru, Luca, et.al. .
Journal: Cerebral cortex (New York, N.Y. : 1991) (Cereb Cortex), 2017 .
Snippet: We previously reported that, in cultured neurons, shRNA-mediated down-regulation of TSPAN7 affects AMPAR trafficking by enhancing PICK1-GluA2 interaction, thereby increasing the intracellular retention of AMPAR.
Affiliation: CNR Institute of Neuroscience, 20129 Milano, Italy. Department of Medical Biotechnology and Translational Medicine, Università degli studi di Milano, Via Vanvitelli 32, 20129 Milano, Italy. Department of Pharmacological and Biomolecular Sciences (DiSFeB), Università di Milano, Via Balzaretti 9, 20133 Milano, Italy. Department of Biosciences and Centre for Stem Cell Research, University of Milan and Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi" Milan, Italy. Fondazione Umberto Veronesi, Piazza Velasca 5, 20122 Milan, Italy. Biological and Environmental Sciences and Engineering Division, King Abdullah University for Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia. Division of Neuroscience, IRCSS San Raffaele Scientific Institute, 20132 Milan, Italy. Department of Medical Biotechnology and Translational Medicine, Università degli studi di Milano,Via Vanvitelli 32, 20129 Milano,Italy. .
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7: Title: TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells.
Journal: Biochemical Society transactions (Biochem Soc Trans), Vol. 45 (3): 703-708, 2017 .
Snippet: While studying the function of TSPAN7 in the control of actin nucleation, we also discovered the existence in DCs of two opposing forces at the plasma membrane: actin nucleation, a protrusive force which seems to counterbalance actomyosin contraction.
Affiliation: Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, U.S.A. mickael.menager@institutimagine.org. .
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8: Title: Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.
Authors: Lee, Seol-Ae, et.al. .
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (Faseb J), Vol. 31 (6): 2301-2313, 2017 .
Snippet: Immunocytochemical analysis revealed that TSPAN7 that resides in the plasma membrane and early and late endosomes promoted internalization of DRD2 and its localization to endosomal compartments of the endocytic pathway.
Affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, South Korea. Department of Life Sciences, Pohang University of Science and Technology, Pohang, South Korea skpark@postech.ac.kr. .
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9: Title: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.
Authors: Salas, Isabel H, et.al. .
Journal: PloS one, Vol. 12 (2): e0171968, 2017 .
Snippet: Interestingly, mutations in Tspan7, highly homologous to Tspan6, are associated with X-linked intellectual disability, suggesting that these two proteins are important for cognition.
Affiliation: VIB Center for Biology of Disease - VIB, Leuven, Belgium. Center of Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), KU Leuven, Leuven, Gasthuisberg O&N4, Belgium. Laboratory of Biological Psychology, KU Leuven, Leuven, Belgium. Centro de Biologıa Molecular 'Severo Ochoa' (CSIC/UAM), Madrid, Spain. .
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10: Title: Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Authors: Seipold, Lisa, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1864 (1): 217-230, 2017 .
Snippet: Despite existing knowledge about the role of the A Disintegrin and Metalloproteinase 10 (ADAM10) as the α-secretase involved in the non-amyloidogenic processing of the amyloid precursor protein (APP) and Notch signalling we have only limited information about its regulation.
Affiliation: Institut für Biochemie, Christian-Albrechts-Universität zu Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany. Czech Centre for Phenogenomics and Laboratory of Transgenic Models of Diseases, Division BIOCEV, Institute of Molecular Genetics of the CAS, v. v. i., Vestec, Czech Republic. Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Biomedical Center, Ludwig-Maximilians-University, 81337 Munich, Germany. Department of Pharmacology and Therapeutics, School of Medicine, University College Cork, Cork, Ireland. Institut für Biochemie, Christian-Albrechts-Universität zu Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany. Electronic address: psaftig@biochem.uni-kiel.de. .
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11: Title: Tetraspanin 7 regulates sealing zone formation and the bone-resorbing activity of osteoclasts.
Authors: Kwon, Jun-Oh, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 477 (4): 1078-84, 2016 .
Snippet: Decreases in acetylated microtubules and levels of phosphorylated Src and Pyk2 in Tspan7 knock-down cells supported the involvement of Tspan7 in cytoskeletal rearrangement signaling in osteoclasts.
Affiliation: Department of Cell and Developmental Biology, BK21 Program and DRI, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea. Department of Cell and Developmental Biology, BK21 Program and DRI, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea. Electronic address: hhbkim@snu.ac.kr. .
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12: Title: The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis.
Authors: Usardi, Alessia, et.al. .
Journal: Developmental neurobiology (Dev Neurobiol), Vol. 77 (1): 75-92, 2017 .
Snippet: Biochemical experiments demonstrate that, in the developing brain, IGSF3 is in a complex with the tetraspanin TSPAN7, a membrane protein mutated in several forms of X-linked intellectual disabilities.
Affiliation: Team Mice, Molecules and Synapse Formation, CIRB, Collège de France, CNRS, INSERM, PSL* Research University, Paris, France, 75231, Cedex 05. .
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13: Title: A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes.
Authors: Krishnan, Neeraja M, et.al. .
Journal: Molecular cancer research : MCR (Mol Cancer Res), Vol. 14 (9): 805-19, 2016 .
Snippet: Finally, differential methylation in FUT3, TRIM5, TSPAN7, MAP3K8, RPS6KA2, SLC9A9, and NPAS3 genes was found to be predictive of certain clinical and epidemiologic parameters.
Affiliation: Ganit Labs, Bio-IT Centre, Institute of Bioinformatics and Applied Biotechnology, Bangalore, India. Integrated Head and Neck Oncology Program, Mazumdar Shaw Centre for Translational Research, Bangalore, India. Head and Neck Oncology, Mazumdar Shaw Medical Centre, Bangalore, India. Integrated Head and Neck Oncology Program, Mazumdar Shaw Centre for Translational Research, Bangalore, India. Head and Neck Oncology, Mazumdar Shaw Medical Centre, Bangalore, India. Ganit Labs, Bio-IT Centre, Institute of Bioinformatics and Applied Biotechnology, Bangalore, India. Strand Life Sciences, Bangalore, India. binay@ganitlabs.in. .
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14: Title: Tetraspanin 7 autoantibodies in type 1 diabetes.
Authors: Walther, Denise, et.al. .
Journal: Diabetologia, Vol. 59 (9): 1973-6, 2016 .
Snippet: METHODS: Full length and external domain fragments of tetraspanin 7 were expressed as luciferase-tagged fusion proteins and used in immunoprecipitation assays to measure autoantibodies in samples from 363 patients with type 1 diabetes at onset of disease, 503 beta cell autoantibody negative first-degree relatives of patients, and 212 relatives with autoantibodies to insulin, glutamic acid decarboxylase, insulinoma antigen 2 or zinc transporter 8. RESULTS: Antibody binding was observed against the full length and external domains of tetraspanin 7, and was strongest against the full length protein.
Affiliation: DFG Research Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Fetscherstrasse 105, 01307, Dresden, Germany. Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Neuherberg, Germany. Forschergruppe Diabetes e.V., Neuherberg, Germany. Institute of Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany. DFG Research Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Fetscherstrasse 105, 01307, Dresden, Germany. ezio.bonifacio@crt-dresden.de. Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Technische Universität Dresden, Dresden, Germany. ezio.bonifacio@crt-dresden.de. .
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15: Title: Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells.
Authors: Ménager, Mickaël M, et.al. .
Journal: Cell, Vol. 164 (4): 695-709, 2016 .
Snippet: We identified TSPAN7 and DNM2, which control actin nucleation and stabilization, as having important and distinct roles in limiting HIV-1 endocytosis and in maintaining virus particles on dendrites, which is required for efficient transfer to T lymphocytes.
Affiliation: Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: mickael.menager@med.nyu.edu. Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute. Electronic address: dan.littman@med.nyu.edu. .
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16: Title: X-linked intellectual disability related genes disrupted by balanced X-autosome translocations.
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet), Vol. 168 (8): 669-77, 2015 .
Snippet: While gene expression analysis showed absence of TSPAN7 and KIAA2022 expression in the patients, the unexpected expression of IL1RAPL1 suggested a fusion transcript ZNF611-IL1RAPL1 under the control of the ZNF611 promoter, gene disrupted at the autosomal breakpoint.
Affiliation: Department of Morphology and Genetics, Genetics Division, Universidade Federal de São Paulo, São Paulo, Brazil. Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany. Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil. Departament of Genetics, Instituto de Biocincias de Botucatu, Universidade Estadual de São Paulo, São Paulo, Brazil. .
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17: Title: PADPIN: protein-protein interaction networks of angiogenesis, arteriogenesis, and inflammation in peripheral arterial disease.
Authors: Chu, Liang-Hui, et.al. .
Journal: Physiological genomics (Physiol Genomics), Vol. 47 (8): 331-43, 2015 .
Snippet: Our bioinformatics analysis identified several genes that are differentially expressed between the two mouse strains with known functions in PAD including TLR4, THBS1, and PRKAA2 and several genes with unknown functions in PAD including EphA4, TSPAN7, SLC22A4, and EIF2a.
Affiliation: Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland; chulianghui@gmail.com. Cardiovascular Medicine, Department of Medicine, and the Robert M. Berne Cardiovascular Research Center University of Virginia School of Medicine, Charlottesville, Virginia; and. Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland; High-Throughput Biology Center, Johns Hopkins University, Baltimore, Maryland. Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland; .
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18: Title: Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo.
Authors: Cheong, Chee Man, et.al. .
Journal: Experimental cell research (Exp Cell Res), Vol. 332 (1): 24-38, 2015 .
Snippet: While TSPAN7 overexpression did not affect cell proliferation in vitro, TSPAN7 increased 5TGM1 cell adhesion to BM stromal cells and transendothelial migration.
Affiliation: Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA, Australia. Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA, Australia; Department of Haematology, SA Pathology, Adelaide 5000, SA, Australia. Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA, Australia; School of Medicine, University of Adelaide, Adelaide 5005, SA, Australia. Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA, Australia; Department of Haematology, SA Pathology, Adelaide 5000, SA, Australia; School of Medicine, University of Adelaide, Adelaide 5005, SA, Australia. Department of Haematology, SA Pathology, Adelaide 5000, SA, Australia. Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA, Australia; Department of Haematology, SA Pathology, Adelaide 5000, SA, Australia; School of Medicine, University of Adelaide, Adelaide 5005, SA, Australia; Centre for Cancer Biology and Hanson Institute, SA Pathology, Adelaide 5000, SA, Australia; Centre for Personalised Cancer Medicine, University of Adelaide, Adelaide 5000SA, Australia. Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, and South Australian Health and Medical Research Institute (SAHMRI), Adelaide 5000, SA, Australia; Department of Haematology, SA Pathology, Adelaide 5000, SA, Australia; School of Medicine, University of Adelaide, Adelaide 5005, SA, Australia. Electronic address: kate.vandyke@health.sa.gov.au. .
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19: Title: Systematic evaluation of the prognostic impact and intratumour heterogeneity of clear cell renal cell carcinoma biomarkers.
Authors: Gulati, Sakshi, et.al. .
Journal: European urology (Eur Urol), Vol. 66 (5): 936-48, 2014 .
Snippet: and 20 and deletions of 4p, 9p, 9p21.3p24.1, and 22q; low EDNRB and TSPAN7 expression and six gene expression signatures) were validated as predictors of poor CSS in univariate analysis.
Affiliation: Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, London, UK. Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute, London, UK. Centre for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark. The Royal Marsden Hospital, London, UK. Centre for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA. Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, London, UK. Electronic address: paul.batest@cancer.org.uk. Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute, London, UK; UCL Cancer Institute, London, UK. Electronic address: charles.swanton@cancer.org.uk. Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute, London, UK; Present address: Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. .
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20: Title: Identification of novel sphingolipid-binding motifs in mammalian membrane proteins.
Authors: Björkholm, Patrik, et.al. .
Journal: Biochimica et biophysica acta (Biochim Biophys Acta), Vol. 1838 (8): 2066-70, 2014 .
Snippet: From these motif-containing candidate proteins, four with different numbers of transmembrane helices were selected for experimental study: i) major histocompatibility complex II Q alpha chain subtype (DQA1), ii) GPI-attachment protein 1 (GAA1), iii) tetraspanin-7 TSN7, and iv), metabotropic glutamate receptor 2 (GRM2).
Affiliation: Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden; Science for Life Laboratory, Stockholm University, SE-171 21 Solna, Sweden. Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany. .
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