refine search
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
54 documents found
1: Title: Efficient Gene Editing of Human Induced Pluripotent Stem Cells Using CRISPR/Cas9.
Authors: Yumlu, Saniye, et.al. .
Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol), Vol. 1961, 2019 .
Snippet: The generation of such mutants in human induced pluripotent stem cells (iPSCs) is of an utmost importance as these cells carry the potential to be differentiated into any cell lineage.
Affiliation: Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany. Berlin Institute of Health, Berlin, Germany. Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany. ralf.kuehn@mdc-berlin.de. Berlin Institute of Health, Berlin, Germany. ralf.kuehn@mdc-berlin.de. .
Related Products: order online
2: Title: Structural insights into the duplex DNA processing of TREX2.
Authors: Cheng, Hiu-Lo, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 46 (22): 12166-12176, 2018 .
Snippet: The three prime repair exonuclease 2 (TREX2) is an essential 3'-to-5' exonuclease that functions in cell proliferation, genome integrity and skin homeostasis maintenance.
Affiliation: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan 30050, ROC. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan 30068, ROC. Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, ROC. Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan 70101, ROC. Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, Taiwan 30068, ROC. .
Related Products: order online
3: Title: Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1.
Authors: Kweon, Jiyeon, et.al. .
Journal: Nature communications (Nat Commun), Vol. 8 (1): 1723, 2017 .
Snippet: Furthermore, we demonstrate that fgRNAs can be used in multiplex genome editing and orthogonal genome manipulation with two types of Cas proteins.
Affiliation: Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 05505, Republic of Korea. Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea. Center for Genome Engineering, Institute for Basic Science, Seoul, 08826, Republic of Korea. Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 05505, Republic of Korea. yongsub1.kim@gmail.com. .
Related Products: order online
4: Title: Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.
Authors: Manils, Joan, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 11902, 2017 .
Snippet: Here we report that lack of Trex2 results in the accumulation of DNA fragments in the cytoplasm of cornifying lingual keratinocytes and co-deletion of DNase1L2 and Trex2 causes massive accumulation of DNA fragments throughout the cornified layers of the tongue epithelium.
Affiliation: Departament de Patologia i Terapèutica Experimental, Facultat de Medicina i Ciències de la Salut, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. The Francis Crick Institute-Mill Hill Laboratory, London, NW7 1AA, United Kingdom. Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria. Unit of Pathology of Laboratory Animals, University of Veterinary Medicine, Vienna, Austria. Departament d'Immunologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. Program of Predictive and Personalized Medicine of Cancer (PMPPC) - Institute Germans Trias i Pujol (IGTP), Badalona, Barcelona, Spain. Josep Carreras Leukaemia Research Institute (IJC), ICO-Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain. Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria. leopold.eckhart@meduniwien.ac.at. Departament de Patologia i Terapèutica Experimental, Facultat de Medicina i Ciències de la Salut, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. concepciosoler@ub.edu. .
Related Products: order online
5: Title: A Multipurpose Toolkit to Enable Advanced Genome Engineering in Plants.
Authors: Čermák, Tomáš, et.al. .
Journal: The Plant cell (Plant Cell), Vol. 29 (6): 1196-1217, 2017 .
Snippet: Mutagenesis can be further enhanced 2.5-fold by incorporating the Trex2 exonuclease.
Affiliation: Department of Genetics, Cell Biology, and Development and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455. Department of Plant Pathology, University of Minnesota, St. Paul, Minnesota 55108. Department of Agronomy and Plant Genetics, University of Minnesota, St. Paul, Minnesota 55108. Department of Plant Developmental Genetics, Institute of Biophysics of the CAS, CZ-61265 Brno, Czech Republic. Department of Genetics, Cell Biology, and Development and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455 voytas@umn.edu. .
Related Products: order online
6: Title: Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency.
Authors: Bhargava, Ragini, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 114 (4): 728-733, 2017 .
Snippet: Furthermore, ATM suppresses rearrangement formation in an experimental condition, in which C-NHEJ is the predominant EJ repair event (i.e., expression of the 3' exonuclease Trex2).
Affiliation: Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010. Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010. Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010; jstark@coh.org. .
Related Products: order online
7: Title: TREX through Cutaneous Health and Disease.
Journal: The Journal of investigative dermatology (J Invest Dermatol), Vol. 136 (12): 2337-2339, 2016 .
Snippet: The importance of these enzymes to cutaneous integrity is observed when TREX1 and TREX2 pathways become aberrant, and autoimmune or cancerous diseases ensue.
Affiliation: Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: alicia@pitt.edu. .
Related Products: order online
8: Title: The Exonuclease Trex2 Shapes Psoriatic Phenotype.
Authors: Manils, Joan, et.al. .
Journal: The Journal of investigative dermatology (J Invest Dermatol), Vol. 136 (12): 2345-2355, 2016 .
Snippet: Similarly, the imiquimod (IMQ)- and Il23-induced mouse psoriasis was associated with a substantial upregulation of Trex2, which was recruited into fragmented chromatin in keratinocytes that were undergoing impaired proliferation, differentiation, and cell death, indicating an important role in DNA processing.
Affiliation: Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. Institute for Predictive and Personalized Medicine of Cancer (IMPPC), Can Ruti Campus, Badalona, Barcelona, Spain; Josep Carreras Leukaemia Research Institute, Can Ruti Campus, Badalona, Barcelona, Spain. Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain; IDIBELL and Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain. Institute for Predictive and Personalized Medicine of Cancer (IMPPC), Can Ruti Campus, Badalona, Barcelona, Spain. Department of Dermatology, Hospital del Mar, Barcelona, Spain. Protecció Radiològica, Centres Científics i Tecnològics, Universitat de Barcelona, Barcelona, Spain. Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: concepciosoler@ub.edu. .
Related Products: order online
9: Title: Germinal Center B-Cell-Associated Nuclear Protein (GANP) Involved in RNA Metabolism for B Cell Maturation.
Authors: Sakaguchi, N, et.al. .
Journal: Advances in immunology (Adv Immunol), Vol. 131, 2016 .
Snippet: Germinal center B-cell-associated nuclear protein (GANP) is upregulated in germinal center B cells against T-cell-dependent antigens in mice and humans.
Affiliation: WPI Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan; Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. Electronic address: nobusaka@ifrec.osaka-u.ac.jp. WPI Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan; Laboratory of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. .
Related Products: order online
10: Title: Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy.
Journal: Antiviral research (Antiviral Res), Vol. 126, 2016 .
Snippet: While testing the activity of HIV pol-specific zinc finger nucleases (ZFNs) alone or in combination with three prime repair exonuclease 2 (Trex2), we identified a treatment-resistant and infectious mutant virus that was derived from a ZFN-mediated disruption of reverse transcriptase (RT).
Affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: hdesilva@fredhutch.org. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: dstone2@fredhutch.org. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Microbiology, University of Washington, Seattle, WA, USA; Department of Biochemistry, University of Washington, Seattle, WA, USA. Electronic address: harlan.pietz@nih.gov. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: proychou@fredhutch.org. Department of Laboratory Medicine, University of Washington, Seattle, WA, USA. Electronic address: agrening@uw.edu. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: jschiffe@fredhutch.org. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: maubert@fredhutch.org. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA; Department of Microbiology, University of Washington, Seattle, WA, USA. Electronic address: kjerome@fredhutch.org. .
Related Products: order online
11: Title: 1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex.
Authors: Valkov, Eugene, et.al. .
Journal: Acta crystallographica. Section F, Structural biology communications (Acta Crystallogr Sect F Struct Biol Commun), Vol. 71 (Pt 10): 1318-21, 2015 .
Snippet: The duplex shows C-A, U-U and C-C noncanonical base pairings together with canonical Watson-Crick A-U and G-C pairs and a G-U wobble.
Affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England. .
Related Products: order online
12: Title: Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.
Authors: Manils, Joan, et.al. .
Journal: Oncotarget, Vol. 6 (26): 22375-96, 2015 .
Snippet: Notably, TREX2 was recruited to low-density nuclear chromatin and micronuclei, where it interacted with phosphorylated H2AX histone, which is a critical player in both DNA repair and cell death.
Affiliation: Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria. Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Dermatology Departament, Hospital del Mar, Barcelona, Spain. Department of Otolaryngology, Hospital Universitario Central de Asturias, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain. Plataforma de Recerca Aplicada en Animal de Laboratori, Parc Científic de Barcelona, Barcelona, Spain. Protecció Radiològica, Universitat de Barcelona, Barcelona, Spain. Institute of Predictive and Personalized Medicine of Cancer, Badalona, Barcelona, Spain. .
Related Products: order online
13: Title: BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.
Authors: Bhatia, Vaibhav, et.al. .
Journal: Nature, Vol. 511 (7509): 362-5, 2014 .
Snippet: It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and export of messenger ribonucleoprotein (mRNP) also induce DNA damage and genome instability.
Affiliation: Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain. .
Related Products: order online
14: Title: Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export.
Authors: Jani, Divyang, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 42 (10): 6686-97, 2014 .
Snippet: The conserved Sac3:Thp1:Sem1:Sus1:Cdc31 (TREX2) complex binds to nuclear pore complexes (NPCs) and, in addition to integrating mRNA nuclear export with preceding steps in the gene expression pathway, facilitates re-positioning of highly regulated actively transcribing genes (such as GAL1) to NPCs.
Affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK ms@mrc-lmb.cam.ac.uk. .
Related Products: order online
15: Title: In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease.
Authors: Aubert, Martine, et.al. .
Journal: Molecular therapy. Nucleic acids (Mol Ther Nucleic Acids), Vol. 3, 2014 .
Snippet: Exposure to histone deacetylase inhibitors prior to HSV1m5/Trex2 treatment increased mutagenesis frequencies of latent HSV genomes another two- to fivefold, suggesting that chromatin modification may be a useful adjunct to gene-targeting approaches.
Affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA. 1] Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA [2] Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA. Cellectis Therapeutics, Paris, France. 1] Department of Pediatrics, University of Washington, Seattle, Washington, USA [2] Department of Immunology, University of Washington, Seattle, Washington, USA [3] Seattle Children's Research Institute, Seattle, Washington, USA. 1] Cellectis Therapeutics, Paris, France [2] Department of Pediatrics, University of Washington, Seattle, Washington, USA [3] Department of Immunology, University of Washington, Seattle, Washington, USA [4] Seattle Children's Research Institute, Seattle, Washington, USA. .
Related Products: order online
16: Title: Human TREX2 components PCID2 and centrin 2, but not ENY2, have distinct functions in protein export and co-localize to the centrosome.
Authors: Cunningham, Corey N, et.al. .
Journal: Experimental cell research (Exp Cell Res), Vol. 320 (2): 209-18, 2014 .
Snippet: Furthermore, the presence of PCID2 at the centrosome is prevalent throughout the cell cycle as determined by co-staining with cyclins E, A and B. PCID2 but not ENY2 is also involved in protein export.
Affiliation: Westminster College, Department of Biology, 319 South Market Street, New Wilmington, PA 16172, USA. Section of Cell and Developmental Biology, Division of Biological Sciences, University of California - San Diego, 9500 Gilman Drive, #0347, La Jolla, CA 92093-0347, USA. Westminster College, Department of Biology, 319 South Market Street, New Wilmington, PA 16172, USA. Electronic address: resendkk@westminster.edu. .
Related Products: order online
17: Title: Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes.
Authors: Hu, Lingchuan, et.al. .
Journal: Nature, Vol. 501 (7468): 569-72, 2013 .
Snippet: TREX2 associated with UBC13 and enhanced PCNA ubiquitination in response to ultraviolet light, consistent with it being a novel member of EF-PRR.
Affiliation: Department of Molecular Medicine/Institute of Biotechnology, The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245-3207, USA. .
Related Products: order online
18: Title: The human TREX-2 complex is stably associated with the nuclear pore basket.
Authors: Umlauf, David, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 126 (Pt 12): 2656-67, 2013 .
Snippet: The THO/TREX complex couples transcription to mRNA export and recruits the mRNA export receptor NXF1 for the transport of messenger ribonucleoprotein particles (mRNP) to the NPC.
Affiliation: Cellular Signaling and Nuclear Dynamics Program, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U964, Université de Strasbourg, BP 10142 - 67404 ILLKIRCH Cedex, CU de Strasbourg, France. .
Related Products: order online
19: Title: Exome resequencing identifies potential tumor-suppressor genes that predispose to colorectal cancer.
Authors: Smith, Christopher G, et.al. .
Journal: Human mutation (Hum Mutat), Vol. 34 (7): 1026-34, 2013 .
Snippet: We sought somatic mutations in the corresponding genes in the CRCs of the patients harboring the germline lesions and found biallelic inactivation of FANCM, LAMB4, PTCHD3, LAMC3, and TREX2, potentially implicating these genes as tumor suppressors.
Affiliation: Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK. .
Related Products: order online
20: Title: Sus1/ENY2: a multitasking protein in eukaryotic gene expression.
Authors: Galán, Amparo, et.al. .
Journal: Critical reviews in biochemistry and molecular biology (Crit Rev Biochem Mol Biol), Vol. 47 (6): 556-68, 2012 Nov-Dec .
Snippet: Sus1 is necessary for histone H2B deubiquitination, mRNA export and gene gating.
Affiliation: Centro de Investigación Príncipe Felipe, CIPF. Gene Expression coupled to RNA Transport Laboratory, Eduardo Primo Yúfera, Valencia, Spain. .
Related Products: order online
Page 1 2 3 
Documents per page: 20 | 50 | 100