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10 documents found
1: Title: Endothelial Mitochondrial Preprotein Translocase Tomm7-Rac1 Signaling Axis Dominates Cerebrovascular Network Homeostasis.
Authors: Shi, Dan, et.al. .
Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol), Vol. 38 (11): 2665-2677, 2018 .
Snippet: Mechanistically, Tomm7 deficit in endothelial cells induced an increased import of Rac1 (Ras-related C3 botulinum toxin substrate 1) protein into mitochondria and facilitated the mitochondrial Rac1-coupled redox signaling, which incurred angiogenic impairment that underlies cerebrovascular network malformation.
Affiliation: From the Institute of Medical Genetics (D.S., M.Q., L.Z., X.L., L.N., C.L., T.Y., Y.W., Y.C., C.H., D.L., L.I., Y.L., J.L., Y.-H.C.), East Hospital, Tongji University School of Medicine, Shanghai. Heart Health Center (D.S., M.Q., L.Z., X.L., L.N., C.L., T.Y., Y.W., Y.C., C.H., D.L., L.I., Y.L., J.L., Y.-H.C.), East Hospital, Tongji University School of Medicine, Shanghai. Key Laboratory of Arrhythmias of the Ministry of Education of China (D.S., L.Z., X.L., L.N., T.Y., C.H., D.L., L.L., Y.L., J.L., Y.-H.C.), East Hospital, Tongji University School of Medicine, Shanghai. .
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2: Title: Investigating the therapeutic potential and mechanism of curcumin in breast cancer based on RNA sequencing and bioinformatics analysis.
Authors: Wang, Rong, et.al. .
Journal: Breast cancer (Tokyo, Japan) (Breast Cancer), 2017 .
Snippet: PPI network was constructed, and the top DEGs were FOS, VIM, FGF2, MAPK1, SPARC, TOMM7, PSMB10, TCEB2, SOCS1, COL4A1, UQCR11, SERPINE1, and ISG15.
Affiliation: National Research Institute for Health and Family Planning, Beijing, 100081, China. Core Laboratory of Translational Medicine, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China. The 88th Hospital of PLA, Tai'an, 271000, China. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Core Laboratory of Translational Medicine, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China. yinling17vip@163.com. .
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3: Title: Association between Gene Polymorphisms of Seven Newly Identified Loci and Type 2 Diabetes and the Correlate Quantitative Traits in Chinese Dong Populations.
Authors: Liu, Liya, et.al. .
Journal: Iranian journal of public health (Iran J Public Health), Vol. 43 (10): 1345-55, 2014 .
Snippet: The polymorphism of rs2240727 in TOMM7 gene was associated with T2D (odds ratio (OR) = 1.65, per copy of the risk T allele, P = 0.004).
Affiliation: 1. Dept. of Epidemiology and Health Statistics, School of Public Health, Central South University , Changsha, China . ; 2. Dept. of Medical Laboratory, Hunan University of Medicine , Huaihua, China. 1. Dept. of Epidemiology and Health Statistics, School of Public Health, Central South University , Changsha, China . 3. Medical Department of the First Affiliated Hospital of Xiangya, Central South University , Changsha, China. 4. The Institute of Clinical Pharmacology, Central South University , Changsha, China. .
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4: Title: [Association of genetic variants in TOMM7 gene and gene environment interaction with type 2 diabetes in Chinese Dong population].
Authors: Liu, Liya, et.al. .
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban), Vol. 40 (1): 31-8, 2015 .
Snippet: The polymorphism of rs2240727 in TOMM7 gene was associated with T2DM (OR=1.50, per copy of the risk T allele, P=0.004).
Affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078; Department of Medical Laboratory, Hunan University of Medicine, Huaihua Hunan 418000, China. .
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5: Title: High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Authors: Hasson, Samuel A, et.al. .
Journal: Nature, Vol. 504 (7479): 291-5, 2013 .
Snippet: This led to characterization of TOMM7 as essential for stabilizing PINK1 on the outer mitochondrial membrane following mitochondrial damage.
Affiliation: 1] Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA [2] Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, USA [3]. 1] Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA [2]. Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, USA. NIH Center for Regenerative Medicine, Bethesda, Maryland 20892, USA. .
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6: Title: Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
Authors: Below, J E, et.al. .
Journal: Diabetologia, Vol. 54 (8): 2047-55, 2011 .
Snippet: RESULT: The top signals (unadjusted p value <1 × 10(-5)) included 49 single nucleotide polymorphisms (SNPs) in eight gene regions (PER3, PARD3B, EPHA4, TOMM7, PTPRD, HNT [also known as RREB1], LOC729993 and IL34) and six intergenic regions.
Affiliation: Department of Human Genetics, University of Chicago, Chicago, IL, USA. .
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7: Title: [Study on invasion and metastasis-associated genes of lung cancer related with NM23-H1 gene].
Authors: Cai, Chun-ji, et.al. .
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban), Vol. 41 (6): 941-5, 2010 .
Snippet: After real-time quantitative PCR evaluation, we found that the mRNA of 8 genes including PSMA7, SBDS, ODC1, YARS, CSDA, PTP4A1, SHPRH and TOMM7 was up-regulated in the cell line of L9981 after transfected with NM23-H1 gene, whereas the mRNA of PKM2 and GMNN was down-regulated.
Affiliation: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. .
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8: Title: Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane.
Authors: Kato, Hiroki, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 369 (3): 958-63, 2008 .
Snippet: The fungal preprotein translocase of the mitochondrial outer membrane (TOM complex) comprises import receptors Tom70, Tom20, and Tom22, import channel Tom40, and small Tom proteins Tom5, Tom6, and Tom7, which regulate TOM complex assembly.
Affiliation: Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
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9: Title: Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane.
Authors: Johnston, Amelia J, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 277 (44): 42197-204, 2002 .
Snippet: Overexpression of Tom22 in HeLa cells results in the rapid assembly of Tom7 into the 380-kDa complex indicating that Tom22 is rate-limiting for TOM complex formation.
Affiliation: Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia. .
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10: Title: Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells.
Authors: Lee, J S .
Journal: DNA sequence : the journal of DNA sequencing and mapping (Dna Sequence), Vol. 10 (3): 195-8, 1999 .
Snippet: It has 1 site (-SQ-) for DNA-dependent protein kinase (DNA-PK) phosphorylation and 2 sites of myristilation.
Affiliation: Institute for Molecular Biology and Genetics, Seoul National University, South Korea. jslee2@plazal.snu.ac.kr .
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