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11 documents found
1: Title: Correction: Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington's Disease.
Journal: PLoS currents (Plos Curr), Vol. 8, 2016 .
Snippet: [This corrects the article DOI: 10.1371/currents.hd.b966ec2eca8e2d89d2bb4d020be4351e.].
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2: Title: Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington's Disease.
Authors: Fox, Jonathan, et.al. .
Journal: PLoS currents (Plos Curr), Vol. 7, 2015 .
Snippet: Huntington's disease (HD) is caused by a trinucleotide CAG repeat in the huntingtin gene (HTT) that results in expression of a polyglutamine-expanded mutant huntingtin protein (mHTT).
Affiliation: Neuroscience Graduate Program, Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming, USA. .
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3: Title: Extracellular Thiol Isomerases and Their Role in Thrombus Formation.
Authors: Schulman, Sol, et.al. .
Journal: Antioxidants & redox signaling (Antioxid Redox Signal), Vol. 24 (1): 1-15, 2016 .
Snippet: The vascular thiol isomerases are those PDI family members secreted from platelets and/or endothelium (40): PDI, ERp57, ERp5, ERp72, ERp44, ERp29, and TMX3.
Affiliation: Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, Massachusetts. .
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4: Title: Protein disulfide isomerases: Impact of thapsigargin treatment on their expression in melanoma cell lines.
Authors: Silva, Zélia, et.al. .
Journal: International journal of biological macromolecules (Int J Biol Macromol), Vol. 79, 2015 .
Snippet: While SK-MEL-30 PDIs' expression is not THG dose-dependent, an increase in glucose related protein 78 (GRP78), PDIA5, PDIA6, and thioredoxin-related-transmembrane proteins' (TMX3 and TMX4) expression, in response to higher drug concentrations, was observed in MNT-1.
Affiliation: CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade Ciências Médicas da Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal. CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade Ciências Médicas da Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal; Departamentio das Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade Ciências Médicas da Universidade Nova de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal; UEI Parasitologia Médica, Instituto de Higiene e Medicina Tropical da Universidade NOVA de Lisboa, Rua da Junqueira 100, 1349-008 Lisboa, Portugal. Electronic address: cnovo@ihmt.unl.pt. .
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5: Title: Trichinella spiralis: genome database searches for the presence and immunolocalization of protein disulphide isomerase family members.
Authors: Freitas, C P, et.al. .
Journal: Journal of helminthology (J Helminthol), Vol. 90 (1): 62-7, 2016 .
Snippet: In addition to a previously described PDI (PDIA2), endoplasmic reticulum protein (ERp57/PDIA3), ERp72/PDIA4, and the molecular chaperones calreticulin (CRT), calnexin (CNX) and immunoglobulin-binding protein/glucose-regulated protein (BIP/GRP78), we identified orthologues of the human thioredoxin-related-transmembrane proteins (TMX1, TMX2 and TMX3) in the genome protein database, as well as ERp44 (PDIA10) and endoplasmic reticulum disulphide reductase (ERdj5/PDIA19).
Affiliation: Centro Hospitalar de Lisboa Central, EPE - Serviço de Anatomia Patológica,Rua José António Serrano,1150-199Lisboa,Portugal. Unidade de Parasitologia Médica,Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa,Rua da Junqueira 100,1349-008,Portugal. .
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6: Title: Palmitoylated TMX and calnexin target to the mitochondria-associated membrane.
Authors: Lynes, Emily M, et.al. .
Journal: The EMBO journal (Embo J), Vol. 31 (2): 457-70, 2012 .
Snippet: Calnexin shuttles between the rough ER and the mitochondria-associated membrane depending on its palmitoylation status.
Affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. .
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7: Title: Disulphide production by Ero1α-PDI relay is rapid and effectively regulated.
Journal: The EMBO journal (Embo J), Vol. 29 (19): 3318-29, 2010 .
Snippet: We find PDI to be the main substrate of Ero1α, and mixed-disulphide complexes of Ero1 primarily form with PDI, to a lesser extent with the PDI-family members ERp57 and ERp72, but are not detectable with another homologue TMX3.
Affiliation: Department of Biology, University of Copenhagen, Copenhagen, Denmark. .
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8: Title: A male with unilateral microphthalmia reveals a role for TMX3 in eye development.
Authors: Chao, Ryan, et.al. .
Journal: PloS one, Vol. 5 (5): e10565, 2010 .
Snippet: We re-sequenced TMX3 in 162 patients with anophthalmia or microphthalmia, and found two missense substitutions in unrelated patients: c.116G>A, predicting p.Arg39Gln, in a male with unilateral microphthalmia and retinal coloboma, and c.322G>A, predicting p.Asp108Asn, in a female with unilateral microphthalmia and severe micrognathia.
Affiliation: Division of Genetics, Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America. .
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9: Title: Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation.
Authors: Holbrook, Lisa-Marie, et.al. .
Journal: British journal of haematology (Br J Haematol), Vol. 148 (4): 627-37, 2010 .
Snippet: Through the use of immunoblotting, flow cytometry, cell-surface biotinylation and gene array analysis, we report the presence of five additional thiol isomerases in human and mouse platelets and megakaryocytes, namely; ERp57, ERp72, ERp44, ERp29 and TMX3.
Affiliation: Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Whiteknights, Reading, Berkshire. .
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10: Title: Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain.
Authors: Haugstetter, Johannes, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 282 (46): 33859-67, 2007 .
Snippet: We recently discovered the transmembrane protein TMX3, a thiol-disulfide oxidoreductase of the protein disulfide-isomerase family.
Affiliation: Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland. .
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11: Title: Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum.
Authors: Haugstetter, Johannes, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 280 (9): 8371-80, 2005 .
Snippet: The TMX3 gene encodes a protein of 454 amino acid residues that contains a predicted N-terminal signal sequence, a single domain with sequence similarity to thioredoxin and a CGHC active site sequence, a potential transmembrane domain, and a C-terminal KKKD tetrapeptide sequence that matches the classical KKXX-type consensus sequence for ER retrieval of type I transmembrane proteins.
Affiliation: Institute of Biochemistry, ETH Zurich, Zürich CH-8093, Switzerland. .
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