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10 documents found
1: Title: Novel Heparin Receptor Transmembrane Protein 184a Regulates Angiogenesis in the Adult Zebrafish Caudal Fin.
Authors: Farwell, Sara Lynn N, et.al. .
Journal: Frontiers in physiology (Front Physiol), Vol. 8, 2017 .
Snippet: Collectively, our study suggests that Tmem184a is a novel regulator of angiogenesis.
Affiliation: Department of Biological Sciences, Lehigh UniversityBethlehem, PA, United States. .
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2: Title: Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.
Authors: Larder, Rachel, et.al. .
Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A), Vol. 114 (35): 9421-9426, 2017 .
Snippet: Our data support the hypothesis that TMEM18 itself, acting within the central nervous system, is a plausible mediator of the impact of adjacent genetic variation on human adiposity.
Affiliation: University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom. Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0QQ, United Kingdom. Center of Animal Biotechnology and Gene Therapy and Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, 08193 Bellaterra, Spain. Wellcome Genome Campus, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom. University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; so104@medschl.cam.ac.uk apc36@cam.ac.uk. .
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3: Title: Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity.
Authors: Farwell, Sara Lynn N, et.al. .
Journal: Journal of visualized experiments : JoVE (J Vis Exp), 2017 .
Snippet: The present report presents a range of experimental protocols based on the GFP-TMEM184A construct expressed in vascular cells that could easily be adapted for other novel proteins.
Affiliation: Department of Biological Sciences, Lehigh University. Department of Natural Science, DeSales University. Department of Biological Sciences, Lehigh University; ljl0@lehigh.edu. .
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4: Title: Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin.
Authors: Pugh, Raymond J, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 291 (10): 5326-41, 2016 .
Snippet: Commercial antibodies against three separate regions of the TMEM184A human protein were used to identify the TMEM184A protein in vascular smooth muscle cells and endothelial cells.
Affiliation: Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015. From the Departments of Biological Sciences and the Department of Natural Sciences, DeSales University, Center Valley, Pennsylvania 18034. From the Departments of Biological Sciences and. the Department of Chemistry, Lebanon Valley College, Annville, Pennsylvania 17003, and. From the Departments of Biological Sciences and ljl0@lehigh.edu. .
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5: Title: Heparin Decreases in Tumor Necrosis Factor α (TNFα)-induced Endothelial Stress Responses Require Transmembrane Protein 184A and Induction of Dual Specificity Phosphatase 1.
Authors: Farwell, Sara Lynn N, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 291 (10): 5342-54, 2016 .
Snippet: Therefore, TMEM184A functions as a heparin receptor and mediates anti-inflammatory responses of ECs involving decreased JNK and p38 activity.
Affiliation: From the Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015. From the Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, the Department of Chemistry, Lehigh University, Allentown, Pennsylvania 18103. From the Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, the Department of Natural Sciences, DeSales University, Center Valley, Pennsylvania 18034. the Department of Surgery, Lehigh Valley Hospital Center, Allentown, Pennsylvania 18103, and. From the Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, LJL0@lehigh.edu. .
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6: Title: An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.
Authors: Ogaki, Soichiro, et.al. .
Journal: BMC developmental biology (Bmc Dev Biol), Vol. 11, 2011 .
Snippet: Genes, such as Parm1, Tmem184a, Hipk2 and Sox4 were reported to be expressed during early pancreatic development.
Affiliation: Department of Stem Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2-2-1, Kumamoto, Japan. .
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7: Title: Ex vivo magnetofection: a novel strategy for the study of gene function in mouse organogenesis.
Authors: Svingen, Terje, et.al. .
Journal: Developmental dynamics : an official publication of the American Association of Anatomists (Dev Dynam), Vol. 238 (4): 956-64, 2009 .
Snippet: Furthermore, ectopic expression of Tmem184a, a gene of unknown function, in female genital ridges, resulted in failure of gonocytes to enter meiosis.
Affiliation: Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. .
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8: Title: Sdmg1 is a component of secretory granules in mouse secretory exocrine tissues.
Authors: Best, Diana, et.al. .
Journal: Developmental dynamics : an official publication of the American Association of Anatomists (Dev Dynam), Vol. 238 (1): 223-31, 2009 .
Snippet: Furthermore, we show that Sdmg1 expression is up-regulated during pancreas development when regulated secretory granules start to appear, and that Sdmg1 colocalizes with secretory granule markers in adult pancreatic acinar cells.
Affiliation: MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, United Kingdom. .
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9: Title: Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice.
Authors: Best, Diana, et.al. .
Journal: Development (Cambridge, England) (Development), Vol. 135 (8): 1415-25, 2008 .
Snippet: Upregulation of Sdmg1 appears to be part of a larger programme of changes to membrane trafficking pathways in embryonic Sertoli cells, and perturbing secretion in male embryonic gonads in organ culture causes male-to-female germ cell sex reversal.
Affiliation: MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. .
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10: Title: Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation.
Authors: Svingen, Terje, et.al. .
Journal: Reproduction (Cambridge, England) (Reproduction), Vol. 133 (5): 983-9, 2007 .
Snippet: In this study, we investigated the expression of Tmem184a, a novel gene encoding a protein of unknown function, but with predicted kinase activity, during mouse embryogenesis.
Affiliation: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. .
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