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10 documents found
1: Title: Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Authors: Vatakuti, Suresh, et.al. .
Journal: Chemical research in toxicology (Chem Res Toxicol), Vol. 29 (3): 342-51, 2016 .
Snippet: The consensus list of markers includes endoplasmic reticulum stress genes, such as C2ORF30, DNAJB9, DNAJC12, SRP72, TMED7, and UBA5, and a sodium/bile acid cotransporter (SLC10A7).
Affiliation: National Institute for Public Health and the Environment , Bilthoven, The Netherlands. .
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2: Title: The Golgi-Associated Plant Pathogenesis-Related Protein GAPR-1 Enhances Type I Interferon Signaling Pathway in Response to Toll-Like Receptor 4.
Authors: Zhou, Qing, et.al. .
Journal: Inflammation, Vol. 39 (2): 706-17, 2016 .
Snippet: The phosphorylation of GAPR-1 promoted its interaction with TRAM-TRIF dependent inhibitor TMED7, and impaired TMED7-mediated disruption of the TRAM-TRIF complex to trigger IFN-β and the IL10 secretion.
Affiliation: Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, China. Institute of Cancer Stem Cell, Dalian Medical University, Dalian, 116044, China. haolu19860813@126.com. Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, China. pony8980@163.com. Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, China. caizhiming2000@163.com. .
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3: Title: Compartmentalization of membrane trafficking, glucose transport, glycolysis, actin, tubulin and the proteasome in the cytoplasmic droplet/Hermes body of epididymal sperm.
Authors: Au, Catherine E, et.al. .
Journal: Open biology (Open Biol), Vol. 5 (8), 2015 .
Snippet: By electron microscope gold antibody labelling, the Golgi trafficking protein TMED7/p27 localized to unstacked flattened cisternae of the Hermes body, as did GLUT-3, the most abundant protein.
Affiliation: Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 0C7 Department of Medicine, McGill University Health Centre Research Institute, 1001 Decarie Blvd, Montreal, Quebec, Canada H4A 3J1. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 0C7. Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada H3A 1A1. Centre for Cellular Imaging, Sahlgrenska Academy at the University of Gothenburg, PO Box 435, 40530 Gothenburg, Sweden. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 0C7 Department of Medicine, McGill University Health Centre Research Institute, 1001 Decarie Blvd, Montreal, Quebec, Canada H4A 3J1 Royal Victoria Hospital, Center for Translational Biology, RI-MUHC, Glen Site, 1001 Decarie Blvd, Bloc E, Room E02.7210, Montreal, Quebec, Canada H4A 3J1 john.bergeron@mcgill.ca. .
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4: Title: Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance.
Authors: Yu, Shiyan, et.al. .
Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci), Vol. 72 (17): 3343-53, 2015 .
Snippet: Cell biology aspects of TLR function have been intensively studied in professional immune cells, in particular the macrophages and dendritic cells, but not well explored in other specialized epithelial cell types.
Affiliation: Department of Biological Sciences, Rutgers University, Room 206, 195 University Ave., Newark, NJ, 07102, USA. .
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5: Title: Expression, sorting, and segregation of Golgi proteins during germ cell differentiation in the testis.
Authors: Au, Catherine E, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 26 (22): 4015-32, 2015 .
Snippet: During acrosome formation, several Golgi proteins (GBF1, GPP34, GRASP55) localize to both the acrosome and Golgi, while GL54D, TM9SF3, and the Golgi trafficking protein TMED7/p27 are segregated from the acrosome.
Affiliation: Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada Division of Endocrinology and Metabolism, McGill University Health Centre Research Institute, Montreal, QC H3A 1A1, Canada. Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada. Department of Biomedical Engineering Department, McGill University, Montreal, QC H3A 2B4, Canada. Centre for Cellular Imaging, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. Division of Endocrinology and Metabolism, McGill University Health Centre Research Institute, Montreal, QC H3A 1A1, Canada. .
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6: Title: The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.
Journal: Science signaling (Sci Signal), Vol. 7 (336): ra70, 2014 .
Snippet: We found that the p24 family protein TMED7 (transmembrane emp24 protein transport domain containing 7) is required for the trafficking of TLR4 from the endoplasmic reticulum to the cell surface through the Golgi.
Affiliation: Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK. Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. njg11@cam.ac.uk. .
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7: Title: Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma.
Authors: Brodtkorb, Marianne, et.al. .
Journal: Blood, Vol. 123 (7): 1051-4, 2014 .
Snippet: The scores for 6 of the cis-associated NFκB pathway genes (BTK, IGBP1, IRAK1, ROCK1, TMED7-TICAM2, and TRIM37) were significantly associated with transformation.
Affiliation: Centre for Cancer Biomedicine, Oslo University Hospital, Oslo, Norway; .
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8: Title: The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.
Authors: Doyle, Sarah L, et.al. .
Journal: Nature communications (Nat Commun), Vol. 3, 2012 .
Snippet: TMED7 is essential for TAG-mediated disruption of the TRAM/TRIF complex and the degradation of toll-like receptor 4. A TMED homologue, logjam, has a negative role in the Toll and IMD pathways in Drosophila melanogaster; therefore, TMEDs may have a conserved role in the regulation of innate immunity.
Affiliation: Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland. .
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9: Title: The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.
Journal: Developmental biology (Dev Biol), Vol. 341 (1): 154-66, 2010 .
Snippet: We find that Tmed2/p24beta(1) is normally expressed in tissues showing morphological defects in 99J mutant embryos and that these affected tissues lack the TMED2/p24beta(1) oligomerization partners, TMED7/p24gamma(3) and TMED10/p24delta(1).
Affiliation: Department of Pediatrics, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada. loydie.majewska@mcgill.ca .
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10: Title: Identification of differentially expressed genes in metastatic and non-metastatic nasopharyngeal carcinoma cells by suppression subtractive hybridization.
Authors: Yang, Xu-Yu, et.al. .
Journal: Cellular oncology : the official journal of the International Society for Cellular Oncology (Cell Oncol), Vol. 27 (4): 215-23, 2005 .
Snippet: Among these 20 clones, 16 were previously identified genes (flotilin-2, ezrin, pim-3, fli-1, mel, neugrin, znf216, ASB1, raly, UBE2A, keratin6A, TMED7, EIF3S9, FTL, two ribosomal proteins RPL21 and RPL16), two were predicted genes (c9orf74 and MDS006), and two sequences shared no homology with known genes listed in GenBank and may represent novel genes.
Affiliation: Cancer Research Institute of Central South University, Changsha, Hunan 410078, PR China. .
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