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13 documents found
1: Title: TM9SF4 levels determine sorting of transmembrane domains in the early secretory pathway.
Authors: Vernay, Alexandre, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 131 (21), 2018 .
Snippet: In human embryonic kidney (HEK) cells, a TMD carrying a positively charged residue (T-R1) or a negatively charged residue (T-D1) was localized to the endoplasmic reticulum (ER), but partially relocated to the Golgi complex upon overexpression of TM9SF4.
Affiliation: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland. Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland pierre.cosson@unige.ch. .
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2: Title: TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation.
Authors: Sun, Lei, et.al. .
Journal: Cell death and differentiation (Cell Death Differ), Vol. 25 (2): 368-379, 2018 .
Snippet: Knockdown of TM9SF4 with TM9SF4-shRNAs markedly reduced the starvation-induced autophagy in HEK293 cells, the effect of which persisted in the presence of bafilomycin A1.
Affiliation: Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China. Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China. School of Life Sciences, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China. .
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3: Title: A nonmainstream approach against cancer.
Journal: Journal of enzyme inhibition and medicinal chemistry (J Enzyme Inhib Med Chem), Vol. 31 (6): 882-9, 2016 .
Snippet: This finding led to the discovery of a new oncogene TM9SF4 that human malignant cell shares with amoebas.
Affiliation: a Anti-tumor Drug Section, Department of Therapeutic Research, Medicines Evaluation Istituto Superiore di Sanità (National Institute of Health) , Rome , Italy. .
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4: Title: Cancer Cell Cannibalism: A Primeval Option to Survive.
Authors: Lozupone, F, et.al. .
Journal: Current molecular medicine (Curr Mol Med), Vol. 15 (9): 836-41, 2015 .
Snippet: In fact, we discovered that metastatic melanoma cells share with amoebas a transmembrane protein TM9SF4, indeed related to the cannibal behavior of these cells.
Affiliation: Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità (National Institute of Health), Viale Regina Elena, 299, 00161 - Rome, Italy. stefano.fais@iss.it. .
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5: Title: TM9 family proteins control surface targeting of glycine-rich transmembrane domains.
Authors: Perrin, Jackie, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 128 (13): 2269-77, 2015 .
Snippet: In human cells, genetic inactivation of TM9SF4 resulted in an increased retention of glycine-rich TMDs in the endoplasmic reticulum, whereas TM9SF4 overexpression enhanced their surface localization.
Affiliation: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, 1 rue Michel Servet, Geneva 4 CH-1211, Switzerland. Department of Biochemistry, Sciences II, University of Geneva, 30 quai Ernest-Ansermet, Geneva 4 CH-1211, Switzerland. Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, 1 rue Michel Servet, Geneva 4 CH-1211, Switzerland Pierre.Cosson@unige.ch. .
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6: Title: Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells.
Authors: Paolillo, Rosa, et.al. .
Journal: PloS one, Vol. 10 (5): e0126968, 2015 .
Snippet: PURPOSE AND RESULTS: In this study, we first analyzed the expression and regulation of TM9SF4 in normal and leukemic cells and identified TM9SF4 as a gene highly expressed in human quiescent CD34+ hematopoietic progenitor cells (HPCs), regulated during monocytic and granulocytic differentiation of HPCs, both lineages giving rise to mature myeloid cells involved in adhesion, phagocytosis and immunity.
Affiliation: Department of Hematology, Oncology and Molecular Medicine of Istituto Superiore di Sanità, 00161, Rome, Italy. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy; Fondazione Santa Lucia, Rome, Italy. .
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7: Title: TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.
Authors: Lozupone, F, et.al. .
Journal: Oncogene, Vol. 34 (40): 5163-74, 2015 .
Snippet: Here, we demonstrate that TM9SF4 represents a novel V-ATPase-associated protein involved in V-ATPase activation.
Affiliation: Therapeutic Research and Medicines Evaluation Department, Istituto Superiore di Sanità, Rome, Italy. Infectious, Parasitic and Immune-Mediated Diseases Department, Istituto Superiore di Sanità, Rome, Italy. Technology and Health Department, Istituto Superiore di Sanità, Rome, Italy. .
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8: Title: The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila.
Authors: Perrin, Jackie, et.al. .
Journal: Journal of innate immunity (J Innate Immun), Vol. 7 (1): 37-46, 2015 .
Snippet: Here, we show that TM9SF4 and TM9SF2 co-immunoprecipitate with the peptidoglycan recognition protein (PGRP)-LC, which triggers the Drosophila immune response to bacterial infection.
Affiliation: Université Grenoble Alpes, Grenoble, France. .
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9: Title: TM9 and cannibalism: how to learn more about cancer by studying amoebae and invertebrates.
Authors: Fais, Stefano, et.al. .
Journal: Trends in molecular medicine (Trends Mol Med), Vol. 18 (1): 4-5, 2012 .
Snippet: The TM9 protein TM9SF4, important in canonical phagocytosis, is involved in this cannibalism by metastatic cells and may represent a novel therapeutic target.
Affiliation: Anti-Tumour Drugs Section, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità (Italian National Institute of Health), Rome, Italy. .
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10: Title: Comparative analysis of nonaspanin protein sequences and expression studies in zebrafish.
Authors: Pruvot, Benoist, et.al. .
Journal: Immunogenetics, Vol. 62 (10): 681-99, 2010 .
Snippet: Genetic studies in Dictyostelium and Drosophila have shown that TM9SF members are required for adhesion and phagocytosis in innate immune response, furthermore, human TM9SF1 plays a role in the regulation of autophagy and human TM9SF4 in tumor cannibalism.
Affiliation: Faculty of Biology, Dijon, Inserm UMR866, University of Burgundy, Dijon 21000, France. .
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11: Title: The paradox of 20q11.21 amplification in a subset of cases of myeloid malignancy with chromosome 20 deletion.
Authors: Mackinnon, Ruth N, et.al. .
Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer), Vol. 49 (11): 998-1013, 2010 .
Snippet: region contained the complete HCK, TM9SF4, PLAGL2, and POFUT1 genes.
Affiliation: Victorian Cancer Cytogenetics Service, St Vincent's Hospital, Melbourne, Australia. ruth.mackinnon@svhm.org.au .
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12: Title: The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells.
Authors: Lozupone, Francesco, et.al. .
Journal: EMBO reports (Embo Rep), Vol. 10 (12): 1348-54, 2009 .
Snippet: TM9SF4 is predominantly expressed in acidic vesicles of melanoma cells, in which it co-localizes with the early endosome antigens Rab5 and early endosome antigen 1. TM9SF4 silencing induced marked inhibition of cannibal activity, which is consistent with a derangement of intracellular pH gradients, with alkalinization of acidic vesicles and acidification of the cell cytosol.
Affiliation: Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy. francesco.lozupone@iss.it .
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13: Title: TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis.
Authors: Bergeret, Evelyne, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 121 (Pt 20): 3325-34, 2008 .
Snippet: Our study highlights the contribution of phagocytes to host defence in an organism possessing a complex innate immune response and suggests an evolutionarily conserved function of TM9SF4 in eukaryotic phagocytes.
Affiliation: CEA, iRTSV, LTS, 38054 Grenoble, France. .
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