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11 documents found
1: Title: Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases.
Authors: Sundstrom, Jeffrey M, et.al. .
Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci), Vol. 59 (6): 2264-2274, 2018 .
Snippet: Pathway analysis revealed that "Neuroprotective Role of THOP1 in Alzheimer's Disease" and "Unfolded Protein Response" pathways were uniquely enriched in control retinas.
Affiliation: Penn State Hershey Eye Center, Penn State College of Medicine, Hershey, Pennsylvania, United States. Institut de Recerca Hospital Universitari Vall d'Hebron (VHIR), Barcelona, Spain. Instituto de Salud Carlos III (CIBERDEM), Barcelona, Spain. University of Technology, Sydney Australia. Proteomics and Mass Spectrometry Core Facility, Penn State University, Pennsylvania, United States. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Michigan, United States. .
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2: Title: Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.
Authors: Shchetynsky, Klementy, et.al. .
Journal: Arthritis research & therapy (Arthritis Res Ther), Vol. 19 (1): 19, 2017 .
Snippet: THOP1 expression profile was successfully replicated in RNA-seq data from peripheral blood mononuclear cells from healthy controls and non-treated patients with RA, in an independent collection of samples.
Affiliation: Rheumatology Unit, Department of Medicine Centre of Molecular Medicine, CMM:L8:04, Karolinska Institutet/Karolinska University Hospital Solna, 171 61, Stockholm, Sweden. klementy.shchetynsky@ki.se. Rheumatology Unit, Department of Medicine Centre of Molecular Medicine, CMM:L8:04, Karolinska Institutet/Karolinska University Hospital Solna, 171 61, Stockholm, Sweden. .
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3: Title: Local bone marrow renin-angiotensin system in the genesis of leukemia and other malignancies.
Authors: Haznedaroglu, I C, et.al. .
Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci), Vol. 20 (19): 4089-4111, 2016 .
Snippet: Most of the RAS molecules including ACE, ACE2, AGT, AGTR1, AGTR2, AKR1C4, AKR1D1, ANPEP, ATP6AP2, CMA1, CPA3, CTSA, CTSD, CTSG, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, DPP3, EGFR, ENPEP, GPER, HSD11B1, HSD11B2, IGF2R, KLK1, LNPEP, MAS1, MME, NR3C1, NR3C2, PREP, REN, RNPEP, and THOP1 are locally present in the BM microenvironment.
Affiliation: Department of Hematology, Hacettepe University School of Medicine, Ankara, Turkey. ichaznedaroglu@gmail.com. .
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4: Title: The rat placental renin-angiotensin system - a gestational gene expression study.
Authors: Vaswani, Kanchan, et.al. .
Journal: Reproductive biology and endocrinology : RB&E (Reprod Biol Endocrinol), Vol. 13, 2015 .
Snippet: Gene expression of four genes (Angiotensin converting enzyme (Ace), angiotensin converting enzyme 2 (Ace2), membrane metalloendopeptidase (Mme) and angiotensin II receptor 1A (Agtr1a)) were significantly upregulated at E20 whereas two others (Thimet oligopeptidase 1 (Thop1) and Alanyl aminopeptidase (Anpep)) were downregulated at E20 prior to the onset of labour.
Affiliation: Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital Campus, Building 71/918, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. k.vaswani@uq.edu.au. Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital Campus, Building 71/918, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. h.chan4@uq.edu.au. Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital Campus, Building 71/918, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. paliverma@gmail.com. Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital Campus, Building 71/918, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. m.dekker@uq.edu.au. Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital Campus, Building 71/918, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. h.peiris@uq.edu.au. Department of Anatomy & Developmental Biology Monash University, Clayton, VIC, 3800, Australia. r.woodbradley@deakin.edu.au. School of Medicine (Optometry), Deakin University, Pigdons Road, Waurn Ponds, VIC, 3800, Australia. r.woodbradley@deakin.edu.au. Department of Anatomy & Developmental Biology Monash University, Clayton, VIC, 3800, Australia. James.Armitage@bakeridi.edu.au. School of Medicine (Optometry), Deakin University, Pigdons Road, Waurn Ponds, VIC, 3800, Australia. James.Armitage@bakeridi.edu.au. Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital Campus, Building 71/918, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. g.rice@uq.edu.au. Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital Campus, Building 71/918, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. murray.mitchell@uq.edu.au. .
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5: Title: Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer.
Authors: Qi, Lei, et.al. .
Journal: PloS one, Vol. 9 (9): e106665, 2014 .
Snippet: Real-Time PCR and western blotting showed that NSCLC specimens had decreased THOP1 mRNA and protein expression compared to corresponding normal tissues.
Affiliation: Department of Thoracic Surgery, Qi Lu Hospital, Shandong University, Jinan, Shandong Province, China. .
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6: Title: Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis.
Authors: Nomoto, Shuji, et.al. .
Journal: Annals of surgical oncology (Ann Surg Oncol), Vol. 21 Suppl 3, 2014 .
Snippet: We studied THOP1 gene expression by real-time reverse transcriptase polymerase chain reaction.
Affiliation: Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan, snomoto@med.nagoya-u.ac.jp. .
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7: Title: Protein and steroid profiles in follicular fluid after ovarian hyperstimulation as potential biomarkers of IVF outcome.
Authors: Kushnir, Mark M, et.al. .
Journal: Journal of proteome research (J Proteome Res), Vol. 11 (10): 5090-100, 2012 .
Snippet: Identified proteins were associated with the acute response signaling, coagulation system, intrinsic and extrinsic prothrombin activation, complement system, neuroprotective role of THOP1, FXR/RXR activation, role of tissue factor, and growth hormone pathways.
Affiliation: ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, United States. kushnmm@aruplab.com .
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8: Title: Effects of levosimendan on cardiac gene expression profile and post-infarct cardiac remodelling in diabetic Goto-Kakizaki rats.
Authors: Vahtola, Erik, et.al. .
Journal: Basic & clinical pharmacology & toxicology (Basic Clin Pharmacol Toxicol), Vol. 109 (5): 387-97, 2011 .
Snippet: Levosimendan up-regulated 3 genes in the renin-angiotensin system pathway [angiotensin receptor 1 (Agtr1), chymase 1 (Cma1) and thimet oligopeptidase 1 (Thop1)] and down-regulated 3 genes in the glycerolipid metabolism pathway [diacylglycerol kinase gamma (Dgkg), carboxyl ester lipase (Cel) and Diacylglycerol kinase iota].
Affiliation: Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland. .
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9: Title: Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity.
Authors: Pollio, Giuseppe, et.al. .
Journal: Neurobiology of disease (Neurobiol Dis), Vol. 31 (1): 145-58, 2008 .
Snippet: In a comprehensive proteomics study aiming at the identification of proteins associated with amyloid-beta (Abeta)-mediated toxicity in cultured cortical neurons, we have identified Thimet oligopeptidase (THOP1).
Affiliation: Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100 Siena, Italy. .
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10: Title: Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease.
Authors: Torres, M P, et.al. .
Journal: Genomics, Vol. 53 (2): 239-40, 1998 .
Snippet: The mapping position of human endopeptidase 24.15 (THOP1) has previously been reported to be within the linkage region for the late-onset Alzheimer disease AD2 locus on chromosome 19q13.3.
Affiliation: Biology and Biotechnology Program, Lawrence Livermore National Laboratory, Livermore, California, 94550, USA. mtorres@genelogic.com .
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11: Title: Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus.
Authors: Meckelein, B, et.al. .
Journal: Genomics, Vol. 31 (2): 246-9, 1996 .
Snippet: Hybridization to DNA from human-rodent somatic cell hybrids assigned the human gene to chromosome 19.
Affiliation: Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA. .
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