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40 documents found
1: Title: A new mechanism of interferon's antiviral action: Induction of autophagy, essential for paramyxovirus replication, is inhibited by the interferon stimulated gene, TDRD7.
Authors: Subramanian, Gayatri, et.al. .
Journal: PLoS pathogens (Plos Pathog), Vol. 14 (1): e1006877, 2018 .
Snippet: Mechanistic investigation revealed that TDRD7 interfered with the activation of AMP-dependent kinase (AMPK), an enzyme required for initiating autophagy.
Affiliation: Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, OH, United States of America. Department of Immunology, Lerner Research Institute, Cleveland, OH, United States of America. Department of Surgery, University of Toledo College of Medicine, Toledo, OH, United States of America. .
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2: Title: Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans.
Authors: Tan, Yue-Qiu, et.al. .
Journal: Genetics in medicine : official journal of the American College of Medical Genetics (Genet Med), 2017 .
Snippet: Histological analysis was performed for the biopsied testicle sample in one patient, and knockout mice were constructed to verify the phenotype of the mutation in TDRD7.ResultsTwo novel loss-of-function mutations (c.324_325insA (T110Nfs*30) and c.688_689insA (p.Y230X), respectively) of TDRD7 were found in the affected patients from the two unrelated consanguineous families.
Affiliation: Institute of Reproductive and Stem Cell Engineering, College of Basic of Medicine, Central South University, Changsha, China. Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. Key Laboratory of Reproductive and Stem Cell Engineering, National Health and Family Planning Commission, Changsha, China. Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada. Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. .
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3: Title: Biased Duplications and Loss of Members in Tdrd Family in Teleost Fish.
Authors: Chen, Feng, et.al. .
Journal: Journal of experimental zoology. Part B, Molecular and developmental evolution (J Exp Zoolog B Mol Dev Evol), 2017 .
Snippet: Both tdrd6 and tdrd7 were duplicated in the teleost fish, whereas tdrd8 was lost from the original locus.
Affiliation: Hubei Key Laboratory of Cell Homeostasis, Laboratory of Molecular and Developmental Genetics, College of Life Sciences, Wuhan University, Wuhan, P. R. China. .
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4: Title: The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage.
Authors: Jeske, Mandy, et.al. .
Journal: Genes & development (Genes Dev), Vol. 31 (9): 939-952, 2017 .
Snippet: Here, we show that LOTUS (Limkain, Oskar, and Tudor containing proteins 5 and 7) domains present in the germline proteins Oskar, TDRD5 (Tudor domain-containing 5), and TDRD7 bind and stimulate the germline-specific DEAD-box RNA helicase Vasa.
Affiliation: Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. .
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5: Title: Molecular Genetic Analysis of Pakistani Families With Autosomal Recessive Congenital Cataracts by Homozygosity Screening.
Authors: Chen, Jianjun, et.al. .
Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci), Vol. 58 (4): 2207-2217, 2017 .
Snippet: These included five missense, one nonsense, two frame shift, and one splice site mutations, eight of which were novel, in EPHA2, FOXE3, FYCO1, TDRD7, MIP, GALK1, and CRYBA4.
Affiliation: Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States 2Department of Ophthalmology, Shanghai Tenth People's Hospital, and Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States 3State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China. Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States. National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan. Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan. Layton Rahmatulla Benevolent Trust Hospital, Lahore, Pakistan. National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan 5Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan 7National Centre for Genetic Diseases, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan. Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan 7National Centre for Genetic Diseases, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan. The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States 9McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States. .
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6: Title: DND protein functions as a translation repressor during zebrafish embryogenesis.
Authors: Kobayashi, Manami, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 484 (2): 235-240, 2017 .
Snippet: An RNA-binding protein, DND, has been reported to relieve the miR-430-mediated repression of some germ plasm mRNAs such as nanos3 and tdrd7 in primordial germ cells (PGCs).
Affiliation: Department of Biology, Graduate School of Science, Kobe University, Kobe 657-8501, Japan. Department of Biology, Graduate School of Science, Kobe University, Kobe 657-8501, Japan; Organization for Advanced and Integrated Research, Kobe University, Kobe 657-8501, Japan. Department of Biology, Graduate School of Science, Kobe University, Kobe 657-8501, Japan. Electronic address: kunio@kobe-u.ac.jp. .
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7: Title: Comparative analysis of secretory factors from permanent- and deciduous-teeth periodontal ligament cells.
Authors: Kim, Kirim, et.al. .
Journal: Archives of oral biology (Arch Oral Biol), Vol. 71, 2016 .
Snippet: Vasorin (VASN) was expressed more strongly in P-PDL-CM, but tudor domain containing 7 (TDRD7) was expressed more strongly in D-PDL-CM in Western blot analysis.
Affiliation: Department of Pediatric Dentistry, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Republic of Korea. Department of Pediatric Dentistry, College of Dentistry, Kyunghee University, Seoul, Republic of Korea. Department of Periodontics, College of Dentistry, Dankook University, Cheonan, Republic of Korea. Department of Oral Biology, College of Dentistry, Yonsei University, Seoul, Republic of Korea. Department of Pediatric Dentistry, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Republic of Korea. Electronic address: songjs@yuhs.ac. .
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8: Title: RNA-binding proteins in eye development and disease: implication of conserved RNA granule components.
Authors: Dash, Soma, et.al. .
Journal: Wiley interdisciplinary reviews. RNA (Wires Rna), Vol. 7 (4): 527-57, 2016 .
Snippet: In support of these hypotheses, three RBPs and RNP/RNA granule components Tdrd7, Caprin2, and Stau2 are linked to ocular developmental defects such as congenital cataract, Peters anomaly, and microphthalmia in human patients or animal models.
Affiliation: Department of Biological Sciences, University of Delaware, Newark, DE, USA. Department of Biohealth Informatics, School of Informatics and Computing, Indiana University & Purdue University Indianapolis, Indianapolis, IN, USA. Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA. Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA. .
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9: Title: Systems biology of lens development: A paradigm for disease gene discovery in the eye.
Authors: Anand, Deepti, et.al. .
Journal: Experimental eye research (Exp Eye Res), Vol. 156, 2017 .
Snippet: In particular, we now have a functional understanding of regulators such as Pax6, Six3, Sox2, Oct1 (Pou2f1), Meis1, Pnox1, Zeb2 (Sip1), Mab21l1, Foxe3, Tfap2a (Ap2-alpha), Pitx3, Sox11, Prox1, Sox1, c-Maf, Mafg, Mafk, Hsf4, Fgfrs, Bmp7, and Tdrd7 in this tissue.
Affiliation: Department of Biological Sciences, University of Delaware, Newark, DE, USA. Department of Biological Sciences, University of Delaware, Newark, DE, USA; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA. Electronic address: salil@udel.edu. .
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10: Title: Divergent RNA Localisation Patterns of Maternal Genes Regulating Embryonic Patterning in the Butterfly Pararge aegeria.
Authors: Carter, Jean-Michel, et.al. .
Journal: PloS one, Vol. 10 (12): e0144471, 2015 .
Snippet: RNA localisation of the following key maternal effect genes were investigated: caudal (cad), orthodenticle (otd), hunchback (hb) and four nanos (nos) paralogs, as well as TDRD7 a gene containing a key functional domain (OST-HTH/LOTUS) shared with oskar.
Affiliation: Evolutionary Developmental Biology Research Group, Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Gipsy Lane, Headington, Oxford, OX3 0BP, United Kingdom. NERC Centre for Ecology & Hydrology, Maclean Building, Benson Lane, Crowmarsh Gifford, Wallingford, Oxfordshire, OX10 8BB, United Kingdom. .
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11: Title: Deficiency of the RNA binding protein caprin2 causes lens defects and features of peters anomaly.
Authors: Dash, Soma, et.al. .
Journal: Developmental dynamics : an official publication of the American Association of Anatomists (Dev Dyn), Vol. 244 (10): 1313-27, 2015 .
Snippet: BACKGROUND: It was recently demonstrated that deficiency of a conserved RNA binding protein (RBP) and RNA granule (RG) component Tdrd7 causes ocular defects including cataracts in human, mouse and chicken, indicating the importance of posttranscriptional regulation in eye development.
Affiliation: Department of Biological Sciences, University of Delaware, Newark, Delaware. Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, Missouri. Center for Bioinformatics & Computational Biology, University of Delaware, Newark, Delaware. .
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12: Title: Maternal dazap2 Regulates Germ Granules by Counteracting Dynein in Zebrafish Primordial Germ Cells.
Authors: Forbes, Meredyth M, et.al. .
Journal: Cell reports (Cell Rep), Vol. 12 (1): 49-57, 2015 .
Snippet: Through molecular epistasis analyses, we show that MDazap2 is epistatic to Tdrd7 and maintains germ granules in the embryonic germline by counteracting Dynein activity.
Affiliation: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA; Department of Genetics, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA; Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. Electronic address: florence.marlow@einstein.yu.edu. .
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13: Title: Bioinformatics Analysis of Potential Candidates for Therapy of TDRD7 Deficiency-Induced Congenital Cataract.
Authors: Shao, De-Wang, et.al. .
Journal: Ophthalmic research (Ophthalmic Res), Vol. 54 (1): 10-7, 2015 .
Snippet: CONCLUSION: HSPB1, NRAS, immune response, defense response and the related genes LY86, C1QA/C1QB/C1QC may play an important role in the development of congenital cataract induced by TDRD7 deficiency.
Affiliation: Department of Ophthalmology, Air Force General Hospital of PLA, Beijing, China. .
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14: Title: Gonad specific genes in Atlantic salmon (Salmon salar L.): characterization of tdrd7-2, dazl-2, piwil1 and tdrd1 genes.
Authors: Kleppe, Lene, et.al. .
Journal: Gene, Vol. 560 (2): 217-25, 2015 .
Snippet: Expression of tdrd7-2, dazl-2, piwil1 and tdrd1 was detected exclusively in the testis and ovary of juvenile salmon, and transcripts of tdrd7-2, dazl-2 and piwil1 were localized within male and female germ cells.
Affiliation: Institute of Marine Research, P. O. Box 1870 Nordnes, 5817 Bergen, Norway. Electronic address: lene.kleppe@imr.no. Institute of Marine Research, P. O. Box 1870 Nordnes, 5817 Bergen, Norway. Electronic address: anna.wargelius@imr.no. Nofima, Muninbakken 9-13, N-9291 Tromsø, Norway. Electronic address: hanne.johnsen@nofima.no. Institute of Marine Research, P. O. Box 1870 Nordnes, 5817 Bergen, Norway. Electronic address: eva.andersson@imr.no. Institute of Marine Research, P. O. Box 1870 Nordnes, 5817 Bergen, Norway. Electronic address: rolf.brudvik.edvardsen@imr.no. .
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15: Title: Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genes.
Authors: Terrell, Anne M, et.al. .
Journal: Experimental eye research (Exp Eye Res), Vol. 131, 2015 .
Snippet: In addition to these genes, all three LECs also express key lens- and cataract-associated genes, namely Dkk3, Epha2, Hsf4, Jag1, Mab21l1, Meis1, Pknox1, Pou2f1, Sfrp1, Sparc, Tdrd7 and Trpm3.
Affiliation: Department of Biological Sciences, University of Delaware, Newark, DE, USA. Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, MO, USA. Department of Biological Sciences, University of Delaware, Newark, DE, USA; Center for Bioinformatics & Computational Biology, University of Delaware, Newark, DE, USA. Electronic address: salil@udel.edu. .
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16: Title: Pax6- and Six3-mediated induction of lens cell fate in mouse and human ES cells.
Authors: Anchan, Raymond M, et.al. .
Journal: PloS one, Vol. 9 (12): e115106, 2014 .
Snippet: RT-PCR and immunostaining revealed induction of additional lens epithelial or fiber cell differentiation markers including Foxe3, Prox1, α- and β-crystallins, and Tdrd7.
Affiliation: Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, United States of America; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, United States of America. Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, United States of America; Department of Biological Sciences, Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, 9716, United States of America. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, United States of America. Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, United States of America. .
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17: Title: The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster.
Authors: Patil, Veena S, et.al. .
Journal: BMC biology (Bmc Biol), Vol. 12, 2014 .
Snippet: RESULTS: In the current study, we identified the paralog of the Drosophila tej gene, tapas (tap), which is an ortholog of vertebrate Tdrd7.
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18: Title: Comparative quantification of plasma TDRD7 mRNA in cataract patients by real-time polymerase chain reaction.
Authors: Kim, Seong Taeck, et.al. .
Journal: Korean journal of ophthalmology : KJO (Korean J Ophthalmol), Vol. 28 (4): 343-50, 2014 .
Snippet: CONCLUSIONS: Human cataracts and the TDRD7 gene loss-of-function mutations are strongly causally related, as the expression level of plasma TDRD7 mRNA in patients with cataracts was statistically significantly lower than in the normal control group.
Affiliation: Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea. Department of Laboratory Medicine, Chosun University College of Medicine, Gwangju, Korea. .
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19: Title: RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract.
Authors: Zheng, Can, et.al. .
Journal: The Journal of international medical research (J Int Med Res), Vol. 42 (1): 153-63, 2014 .
Snippet: Five single nucleotide polymorphisms (SNPs) within the TDRD7 gene, rs1462091, rs11793735, rs10981985, rs2045732 and rs1462089, were genotyped using a SNaPshot® Multiplex Kit.
Affiliation: Department of Ophthalmology, Research Institute of Field Surgery, Da Ping Hospital, Third Military Medical University, Chongqing, China. .
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20: Title: Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.
Authors: Chapman, Karen M, et.al. .
Journal: Molecular & cellular proteomics : MCP (Mol Cell Proteomics), Vol. 12 (11): 3221-36, 2013 .
Snippet: Mass-spectral analysis of 2D gel protein spots enriched >3-fold in each fraction revealed a heterogeneous RNA binding proteome (hnRNPA2/b1, hnRNPA3, hnRPDL, hnRNPK, hnRNPL, hnRNPM, PABPC1, PABPC4, PCBP1, PCBP3, PTBP2, PSIP1, RGSL1, RUVBL2, SARNP2, TDRD6, TDRD7) abundantly expressed in round spermatids prior to their elongation.
Affiliation: Departments of Pharmacology. .
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