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118 documents found
1: Title: Overexpression of adiponectin alleviates intracerebral hemorrhage-induced brain injury in rats via suppression of oxidative stress.
Authors: Wang, Shaohua, et.al. .
Journal: Neuroscience letters (Neurosci Lett), Vol. 681, 2018 .
Snippet: Furthermore, tetrabromocinnamic acid (TBCA, a NADPH oxidase activator) blocked the effect of APN on cerebral protection and antioxidant activity.
Affiliation: Department of Pathology, The Affiliated hospital of Southwest Medical University, 646000, Luzhou, People's Republic of China; Medical experiment research center, The Affiliated hospital of Southwest Medical University, 646000, Luzhou, People's Republic of China. Department of Pathology, The Affiliated hospital of Southwest Medical University, 646000, Luzhou, People's Republic of China; Medical experiment research center, The Affiliated hospital of Southwest Medical University, 646000, Luzhou, People's Republic of China. Electronic address: yangbo2017@foxmail.com. .
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2: Title: Neuroprotection by aripiprazole against β-amyloid-induced toxicity by P-CK2α activation via inhibition of GSK-3β.
Authors: Park, So Youn, et.al. .
Journal: Oncotarget, Vol. 8 (66): 110380-110391, 2017 .
Snippet: Subsequently, Aβ1-42-induced decreased levels of phosphorylated glycogen synthase-3β at Ser9 (P-GSK-3β) and nuclear P-β-catenin (Ser675) were elevated by aripiprazole, which were inhibited by K252A (inhibitor of BDNF receptor) and tetrabromocinnamic acid (TBCA, CK2 inhibitor), indicating that BDNF and P-CK2α activation are implicated in the aripiprazole effects.
Affiliation: Department of Pharmacology, School of Medicine, Pusan National University, Gyeongsangnam-do 50612, Republic of Korea. Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do 50612, Republic of Korea. Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Gyeongsangnam-do 50612, Republic of Korea. .
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3: Title: Identification of potential pathogenic genes associated with osteoporosis.
Authors: Xia, B, et.al. .
Journal: Bone & joint research (Bone Joint Res), Vol. 6 (12): 640-648, 2017 .
Snippet: In addition, the quantitative reverse transcriptase-polymerase chain reaction result validated the expression of several genes (VPS35, FCGR2A, TBCA, HIRA, TYROBP, and JUND).
Affiliation: Attending Doctor Department of Orthopedics, Jining No. 1 People's Hospital, 272011 Shandong Province, China. Attending Doctor Department of Gynecology, Jining No. 1 People's Hospital, 272011 Shandong Province, China. Attending Doctor Department of Orthopedics, Jining No. 1 People's Hospital, 272011 Shandong Province, China fenglide12@163.com. .
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4: Title: Quantifying the need for enhanced case management for TB patients as part of TB cohort audit in the North West of England: a descriptive study.
Authors: Tucker, Angela, et.al. .
Journal: BMC public health, Vol. 17 (1): 881, 2017 .
Snippet: CONCLUSIONS: Use of TBCA to quantify different levels of need for ECM is feasible and has demonstrated that social and clinical complexity is common in the region.
Affiliation: Department of Clinical Sciences Liverpool School of Tropical Medicine, Liverpool, UK. angelatucker1@nhs.net. Centre for Epidemiology, University of Manchester, Manchester, UK. angelatucker1@nhs.net. North West Public Health England Centre, Liverpool, UK. angelatucker1@nhs.net. University of Liverpool, Liverpool, UK. Public Health England Field Epidemiology Service North West, Liverpool, UK. Department of Respiratory Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK. Department of Clinical Sciences Liverpool School of Tropical Medicine, Liverpool, UK. North West Public Health England Centre, Liverpool, UK. Department of Social Medicine, Karolinska Institutet, Stockholm, Sweden. Institute of Infection and Global Health, University of Liverpool, Liverpool, UK. Tropical and Infectious Diseases Unit, Royal Liverpool and Broadgreen University Hospitals, Liverpool, UK. Paediatric Infectious Diseases, Pennine Acute Hospitals Trust, Bury, UK. .
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5: Title: Nucleotide binding to ARL2 in the TBCD∙ARL2∙β-tubulin complex drives conformational changes in β-tubulin.
Authors: Francis, Joshua W, et.al. .
Journal: Journal of molecular biology (J Mol Biol), 2017 .
Snippet: In addition to prefoldin and the TCP-1 Ring Complex, five tubulin-specific chaperones, termed cofactors A-E (TBCA-E), and GTP are required for the folding of α- and β-tubulin subunits and assembly into heterodimers.
Affiliation: Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, United States. Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, United States. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, United States. Electronic address: rkahn@emory.edu. .
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6: Title: Proteomic alterations of fibroblasts induced by ovarian cancer cells reveal potential cancer targets.
Authors: Zhang, X Y, et.al. .
Journal: Neoplasma, 2017 .
Snippet: Our data showed that the level of CENPE, BAG2, SOD2, GDI2, CORO1C, CFL1, DSTN, CALD1, PHGDH, PDHA1, AKR1B1, TST and TBCA proteins were significantly up-regulated in the fibroblasts co-cultured with ovarian cancer cells, whereas HSPB1, P4HB and VIM were significantly down-regulated.
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7: Title: New insights on thyroid hormone mediated regulation of herpesvirus infections.
Authors: Figliozzi, Robert W, et.al. .
Journal: Cell & bioscience (Unknown Journal), Vol. 7, 2017 .
Snippet: Further studies revealed that CK2 inhibitors tetrabrominated cinnamic acid (TBCA) and 4, 5, 6, 7-tetrabromo-2H-benzotriazole (TBB) both reversed the T3-mediated repression of viral replication.
Affiliation: Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, USA. Department of Natural Sciences, School of Agriculture and Natural Sciences, University of Maryland Eastern Shore, Princess Anne, USA. .
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8: Title: Infantile neurodegenerative disorder associated with mutations in TBCD, an essential gene in the tubulin heterodimer assembly pathway.
Authors: Edvardson, Shimon, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 25 (21): 4635-4648, 2016 .
Snippet: The patients harboured homozygous missense mutations (A475T and A586V) in TBCD, a gene encoding one of five tubulin-specific chaperones (termed TBCA-E) that function in concert as a nanomachine required for the de novo assembly of the α/β tubulin heterodimer.
Affiliation: Neuropediatric Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel. Monique and Jacques Roboh Department of Genetic Research, Hadassah, Hebrew University Medical Center Jerusalem, Jerusalem, Israel. Department of Biochemistry & Molecular Pharmacology, NYU Langone Medical Center, New York, NY, USA. The Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, the University of Western Australia, Nedlands, Western Australia, Australia. Neuropediatric Unit, Shaare Zedek Medical Center; Hebrew University-Hadassah School of Medicine, Jerusalem, Israel. Department of Pediatrics and Genetics, Makassed Hospital, Al-Quds Medical School, Jerusalem. .
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9: Title: A Trimer Consisting of the Tubulin-specific Chaperone D (TBCD), Regulatory GTPase ARL2, and β-Tubulin Is Required for Maintaining the Microtubule Network.
Authors: Francis, Joshua W, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 292 (10): 4336-4349, 2017 .
Snippet: These dimers are the end result of complex folding and assembly events, requiring the TCP1 Ring Complex (TriC or CCT) chaperonin and five tubulin-specific chaperones, tubulin binding cofactors A-E (TBCA-TBCE).
Affiliation: From the Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322. From the Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 rkahn@emory.edu. .
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10: Title: Embryonic exposure to model naphthenic acids delays growth and hatching in the pond snail Lymnaea stagnalis.
Authors: Johnston, Christina U, et.al. .
Journal: Chemosphere, Vol. 168, 2017 .
Snippet: This study examines under laboratory conditions the toxicity of NAs extracted from oil sands process water (OSPW) and the low-molecular weight model NAs cyclohexylsuccinic acid (CHSA), cyclohexanebutyric acid (CHBA), and 4-tert-butylcyclohexane carboxylic acid (4-TBCA) on embryonic development of the snail Lymnaea stagnalis, a common freshwater gastropod with a broad Palearctic distribution.
Affiliation: Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, AB, T2N 1N4, Canada. Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, AB, T2N 1N4, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, AB, T2N 1N4, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, T2N 4N1, Canada. Electronic address: wilderin@ucalgary.ca. .
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11: Title: Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells.
Authors: Freitas, Sara, et.al. .
Journal: Marine drugs (Mar Drugs), Vol. 14 (9), 2016 .
Snippet: A 10-fold decrease of cytoskeleton proteins (STMN1, TBCA) provided a link to alterations of the cell cycle.
Affiliation: Interdisciplinary Center of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. freitas.srf.09@gmail.com. Interdisciplinary Center of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. mrm@estsp.ipp.pt. Health and Environmental Research Center (CISA), School of Apllied Health Sciences of Porto, Polytechnic Porto, Rua Valente Perfeito 322, 4400-330 Vila Nova de Gaia, Portugal. mrm@estsp.ipp.pt. Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Edifício FC4, 4169-007 Porto, Portugal. mrm@estsp.ipp.pt. Institute for Molecular and Cell Biology (IBMC), University of Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. mrm@estsp.ipp.pt. Interdisciplinary Center of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. costa.anamarg@gmail.com. Interdisciplinary Center of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. pleao@ciimar.up.pt. Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal. rvitorino@ua.pt. Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal. rvitorino@ua.pt. Interdisciplinary Center of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. vmvascon@fc.up.pt. Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Edifício FC4, 4169-007 Porto, Portugal. vmvascon@fc.up.pt. Interdisciplinary Center of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. rurbatzka@ciimar.up.pt. .
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12: Title: Protein Kinase CK2 Regulates Leukocyte-Endothelial Cell Interactions during Ischemia and Reperfusion in Striated Skin Muscle.
Authors: Ampofo, Emmanuel, et.al. .
Journal: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes (Eur Surg Res), Vol. 57 (1-2): 111-24, 2016 .
Snippet: Moreover, we analyzed in vivo the effect of CK2 inhibition on leukocyte-endothelial cell interactions in the dorsal skinfold chamber model of I/R injury by means of repetitive intravital fluorescence microscopy and immunohistochemistry. RESULTS: We found that TBCA and CX-4945 suppressed the activity of CK2 in HDMEC without affecting cell viability.
Affiliation: Institute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany. .
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13: Title: Health professionals' experiences of tuberculosis cohort audit in the North West of England: a qualitative study.
Authors: Wallis, Selina K, et.al. .
Journal: BMJ open, Vol. 6 (3): e010536, 2016 .
Snippet: Respondents were purposively sampled from 3 groups involved in the NW TBCA: (1) TB nurse specialists, (2) consultant physicians and (3) public health practitioners.
Affiliation: Department of Clinical Sciences and Centre for Applied Health Research & Delivery, Liverpool School of Tropical Medicine, Liverpool, Merseyside, UK. Department of Public Health and Policy, University of Liverpool, Liverpool, Merseyside, UK. Manchester Royal Infirmary, Manchester, UK. Public Health England, Liverpool, UK. Bolton NHS Trust, Bolton, UK. North Manchester General Hospital, Manchester, UK. Liverpool Community Health Trust, Liverpool, UK. Department of Clinical Sciences and Centre for Applied Health Research & Delivery, Liverpool School of Tropical Medicine, Liverpool, Merseyside, UK Liverpool Heart and Chest Hospital, Liverpool, UK. Department of Clinical Sciences and Centre for Applied Health Research & Delivery, Liverpool School of Tropical Medicine, Liverpool, Merseyside, UK Royal Liverpool University Hospital, Liverpool, UK. .
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14: Title: [Brazilian Food Composition Database (TBCA-USP): Data compilation to serve the public good].
Journal: Archivos latinoamericanos de nutrición (Arch Latinoam Nutr), Vol. 65 (3): 186-92, 2015 .
Snippet: It also indicates extension and update strategies of the TBCA-USP.
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15: Title: Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia.
Authors: Shi, Guang-Xia, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 5, 2015 .
Snippet: Furthermore, the cognitive function and production of O2(-) were determined in the presence and absence of NADPH oxidase agonist (TBCA) and antagonist (Apocynin).
Affiliation: Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China. .
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16: Title: Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.
Authors: Iniaghe, Loretta O, et.al. .
Journal: Neurobiology of disease (Neurobiol Dis), Vol. 82, 2015 .
Snippet: Again, casein kinase 2 inhibitor TBCA and MAFG siRNA abolished the effect of dimethyl fumarate on ICAM-1 and casein kinase 2. Dimethyl fumarate preserved pNrf2 and MAFG expression in the nuclear lysate after ICH and the effect of dimethyl fumarate was abolished by casein kinase 2 inhibitor TBCA and MAFG siRNA.
Affiliation: Department of Physiology and Pharmacology, Loma Linda University, USA; Department of Pharmacology and Toxicology, University of Benin, Nigeria. Department of Physiology and Pharmacology, Loma Linda University, USA; Department of Neurosurgery, Loma Linda University, Loma Linda, CA, USA. Department of Physiology and Pharmacology, Loma Linda University, USA. Department of Pharmacology and Toxicology, University of Benin, Nigeria. Department of Physiology and Pharmacology, Loma Linda University, USA; Department of Anesthesiology, Loma Linda University, Loma Linda, CA, USA. Department of Physiology and Pharmacology, Loma Linda University, USA. Electronic address: jtang@llu.edu. .
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17: Title: Transbronchial Catheter Aspiration and Transbronchial Needle Aspiration in the Diagnostic Workup of Peripheral Lung Lesions.
Authors: Franke, Karl-Josef, et.al. .
Journal: Lung, Vol. 193 (5): 767-72, 2015 .
Snippet: The aim of the present study was to evaluate the diagnostic sensitivity of transbronchial needle aspiration (TBNA) and transbronchial catheter aspiration (TBCA) in addition to transbronchial forceps biopsy (TBB) at conventional bronchoscopy.
Affiliation: Department of Pneumology and Critical Care Medicine, Helios Klinik Ambrock, Chair of Internal Medicine I, Witten/Herdecke University, Ambrocker Weg 60, 58091, Hagen, Germany. karl-josef.franke@helios-kliniken.de. Department of Pneumology and Critical Care Medicine, Helios Klinik Ambrock, Chair of Internal Medicine I, Witten/Herdecke University, Ambrocker Weg 60, 58091, Hagen, Germany. melanie.hein@helios-kliniken.de. Department of Pneumology and Critical Care Medicine, Helios Klinik Ambrock, Chair of Internal Medicine I, Witten/Herdecke University, Ambrocker Weg 60, 58091, Hagen, Germany. ulrike.domanski@helios-kliniken.de. Department of Pneumology and Critical Care Medicine, Helios Klinik Ambrock, Chair of Internal Medicine I, Witten/Herdecke University, Ambrocker Weg 60, 58091, Hagen, Germany. georg.nilius@helios-kliniken.de. Department of Pneumology and Critical Care Medicine, Helios Klinik Ambrock, Chair of Internal Medicine I, Witten/Herdecke University, Ambrocker Weg 60, 58091, Hagen, Germany. maik.schroeder@helios-kliniken.de. Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany. jeremias.wohlschlaeger@uk-essen.de. Institute of Pathology, Diakonissenkrankenhaus, Knuthstraße 1, 24939, Flensburg, Germany. jeremias.wohlschlaeger@uk-essen.de. Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany. dirk.theegarten@uk-essen.de. .
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18: Title: Abnormal Localization and Tumor Suppressor Function of Epithelial Tissue-Specific Transcription Factor ESE3 in Esophageal Squamous Cell Carcinoma.
Authors: Wang, Li, et.al. .
Journal: PloS one, Vol. 10 (5): e0126319, 2015 .
Snippet: To explore the possible mechanism of the differences in localization of ESE3 in normal esophageal cells and ESCC cells, ESCC cell lines were treated with the nuclear export inhibitor leptomycin B, transcription inhibitor actinomycin D, PKC inhibitor sphinganine, P38 MAPK inhibitor SB202190, and CK II inhibitor TBCA.
Affiliation: Department of Gastroenterology & Hepatology, Beijing Digestive Disease Center, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, China. .
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19: Title: The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly.
Authors: Barrack, Keri L, et.al. .
Journal: Acta crystallographica. Section F, Structural biology communications (Acta Crystallogr Sect F Struct Biol Commun), Vol. 71 (Pt 5): 539-46, 2015 .
Snippet: Tubulin-binding cofactor A (TBCA) participates in microtubule formation, a key process in eukaryotic biology to create the cytoskeleton.
Affiliation: Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland. .
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20: Title: The tubulin cofactor A is involved in hyphal growth, conidiation and cold sensitivity in Fusarium asiaticum.
Authors: Zhang, Xiaoping, et.al. .
Journal: BMC microbiology (Bmc Microbiol), Vol. 15, 2015 .
Snippet: Microscopic observation found that hyphae of ΔFaTBCA-3 exhibited blebbing phenotypes after shifting from 25 to 4°C for 1- or 3-day incubation and approximately 72% enlarged nodes contained several nuclei after 3-day incubation at 4°C.
Affiliation: Institute of Biotechnology, Zhejiang University, Hangzhou, China. tao910629@sina.com. Institute of Biotechnology, Zhejiang University, Hangzhou, China. 21216173@zju.edu.cn. Institute of Agriculture Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. jinhuajjh@sina.com. Institute of Biotechnology, Zhejiang University, Hangzhou, China. mhyu@zju.edu.cn. Institute of Biotechnology, Zhejiang University, Hangzhou, China. ynyin@zju.edu.cn. Institute of Biotechnology, Zhejiang University, Hangzhou, China. zhma@zju.edu.cn. .
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