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39 documents found
1: Title: Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK.
Authors: Jin, Un-Ho, .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), 2018 .
Snippet: Results of RNAseq studies indicate that omeprazole induced an AhR-dependent downregulation of several pro-invasion factors including activated leukocyte cell adhesion molecule (ALCAM), long chain fatty acid CoA-synthase (CSL4), stathmin 3 (STMN3) and neuropillin 2 (NRP2), and the specific functions of these genes are currently being investigated.
Affiliation: Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA. Human Genomic Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA. Electronic address: .
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2: Title: Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci.
Authors: Labreche, Karim, .
Journal: Acta neuropathologica (Acta Neuropathol), 2018 .
Snippet: To link risk SNPs to target candidate genes we analysed Hi-C and gene expression data, highlighting the potential role of IDH1 at 2q33.3, MYC at 8q24.21 and STMN3 at 20q13.33.
Affiliation: Sorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, 75013, Paris, France. Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK. Service de neurologie 2-Mazarin, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. University of Pavia and C. Mondino National Institute of Neurology, Pavia, Italy. Univ. Lille, Inserm, Institut Pasteur de Lille, U1167-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, 59000, Lille, France. Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK. .
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3: Title: Overexpression of SCLIP promotes growth and motility in glioblastoma cells.
Authors: Zhang, Yanmin, .
Journal: Cancer biology & therapy (Cancer Biol Ther), Vol. 16 (1): 97-105, 2015 .
Snippet: Overexpression of SCLIP dramatically stimulated tumor cell migration and invasion as well as proliferation and downregulation of SCLIP showed opposite effects, establishing an important oncogenic role for this gene.
Affiliation: a Key Laboratory of the Ministry of Education for Experimental Teratology; Department of Histology and Embryology ; Shandong University School of Medicine ; Jinan , China. .
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4: Title: Both genes and lncRNAs can be used as biomarkers of prostate cancer by using high throughput sequencing data.
Authors: Cheng, W-S, .
Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci), Vol. 18 (22): 3504-10, 2014 .
Snippet: RESULTS: A total of 7112 DEGs were screened, such as ZNF512B, UCKL1, STMN3, GMEB2, and PTK6.
Affiliation: Department of Urology, Taizhou Municipal Hospital, Taizhou, Zhejiang, China. .
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5: Title: Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner.
Authors: Nair, Sajitha, .
Journal: Molecular cancer (Mol Cancer), Vol. 13, 2014 .
Snippet: RESULTS: A microarray analysis showed multiple genes are affected by the depletion of ID1; we focused on two of them: Stathmin-like3 (STMN3), a microtubule destabilizing protein, and GSPT1, a protein involved in translation termination; these proteins were induced by both nicotine and EGF in an ID1 dependent fashion.
Affiliation: Department of Tumor Biology, H, Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA. .
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6: Title: Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members.
Authors: Yip, Yan Y, .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 446 (1): 248-54, 2014 .
Snippet: Moreover, although the JNK-binding motif identified in STMN and SCG10 was not conserved in SCLIP, JNK phosphorylation of SCLIP was inhibited by a substrate competitive peptide (TI-JIP) highlighting kinase-substrate interaction as required for JNK targeting.
Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria, Australia. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria, Australia. Electronic address: .
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7: Title: Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.
Authors: Xie, Xuemei, .
Journal: Molecular cancer therapeutics (Mol Cancer Ther), Vol. 12 (6): 1099-111, 2013 .
Snippet: PEA-15 (phosphoprotein enriched in astrocytes-15 kDa) regulates cell proliferation, autophagy, apoptosis, and glucose metabolism and also mediates AKT-dependent chemoresistance in breast cancer.
Affiliation: Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. .
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8: Title: Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion.
Authors: Hill, Matthew J, .
Journal: Human molecular genetics (Hum Mol Genet), Vol. 21 (5): 1018-24, 2012 .
Snippet: Most consistent gene expression changes were seen for C2ORF80, a gene of as-yet-unknown function, and STMN3, a gene involved in neurite outgrowth and axonal and dendritic branching.
Affiliation: Department of Neuroscience, Institute of Psychiatry, King’s College London, London, UK. .
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9: Title: Annotation and analysis of expressed sequence tags (ESTs) from Chinese sturgeon (Acipenser sinensis) pituitary cDNA library.
Authors: Ma, Jing, .
Journal: Marine genomics (Mar Genomics), Vol. 4 (3): 173-9, 2011 .
Snippet: We performed five hormone related genes including GnRHRI (gonadotropin-releasing hormone receptor I), cpH (carboxypeptidase H), ppiB (peptidylprolyl isomerase B), stmn3 (stathmin-like 3), 7B2 (neuroendocrine protein 7B2), and four novel genes (contig 192, 177, 170 and 168) a semi-quantitative RT-PCR on different tissues from Chinese sturgeon.
Affiliation: School of Life Science, East China Normal University, Shanghai 200062, PR China. .
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10: Title: Position-dependent effect of a neural-restrictive silencer-like element present in the promoter downstream of the SCG10-like protein gene.
Authors: Sone, Kiyoaki, .
Journal: Journal of biochemistry (J Biochem), Vol. 150 (4): 451-60, 2011 .
Snippet: The Neural-restrictive silencer was located downstream of the transcription start site, and showed a position-dependent repressing activity.
Affiliation: Department of Molecular Genetics, National Institute for Longevity Sciences (NILS), Gengo 36-3, Morioka, Oobu, Aichi 474-8522, Japan. .
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11: Title: Increased glycogen synthase kinase-3β mRNA level in the hippocampus of patients with major depression: a study using the stanley neuropathology consortium integrative database.
Authors: Oh, Dong Hoon, .
Journal: Psychiatry investigation (Psychiatry Investig), Vol. 7 (3): 202-7, 2010 .
Snippet: p<0.0001) and stathmin-like 3 (STMN3)(ρ=0.70,
Affiliation: Department of Neuropsychiatry, College of Medicine and Institute of Mental Health, Hanyang University, Seoul, Korea. .
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12: Title: Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10.
Authors: Xu, Hua, .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 285 (6): 3548-53, 2010 .
Snippet: Results show that JLP (Spag9) negatively regulates NGF-induced neurite outgrowth by decreasing the level of phosphorylated SCG10.
Affiliation: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. .
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13: Title: SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells.
Authors: Ng, Dominic C H, .
Journal: The Biochemical journal (Biochem J), Vol. 425 (1): 95-105, 2010 .
Snippet: STAT (signal transducer and activator of transcription) 3 is a key contributor to cancer cell migration and invasion, with excessive STAT3 activity promoting growth arrest, cell-cell dissociation and increased migration of breast cancer epithelial cells.
Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, VIC, Australia 3010. .
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14: Title: Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer.
Authors: Singer, Stephan, .
Journal: Cancer research (Cancer Res), Vol. 69 (6): 2234-43, 2009 .
Snippet: Both stathmin and stathmin-like 3 (SCLIP) were overexpressed in adenocarcinoma as well as squamous cell carcinoma (SCC) tissues and induced tumor cell proliferation, migration, and matrix invasion in respective cell lines.
Affiliation: Institute of Pathology, University of Heidelberg, Thoraxklinik Heidelberg, University of Heidelberg, Germany. .
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15: Title: Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer.
Authors: Fang, Feng, .
Journal: The American journal of pathology (Am J Pathol), Vol. 174 (1): 297-308, 2009 .
Snippet: Real-time PCR confirmed that STMN3, S100A4, S100A6, c-Myb, estrogen receptor alpha, growth hormone receptor, and progesterone receptor were all down-regulated in si-CypB cells.
Affiliation: Breast Cancer Program, Robert H. Lurie Comprehensive Cancer Center & Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA. .
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16: Title: Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis.
Authors: Lips, Esther H, .
Journal: BMC cancer, Vol. 8, 2008 .
Snippet: CONCLUSION: On basis of integrative analysis this study identified one well known CRC gene (SMAD2) and several other genes (EFNA1, BOP1, TGIF2 and STMN3) that possibly could be used for rectal cancer characterization.
Affiliation: Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. .
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17: Title: [Differentially expressed genes in adrenal gland of H22 liver cancer mice with different syndromes and in different stages].
Authors: Pan, Zhi-qiang, .
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao), Vol. 6 (8): 843-51, 2008 .
Snippet: Down-regulated coincident genes included nervous system function-related genes such as Plp1, Mbp, Aldh1a1, Cck, Atn1, genes associated with electrolyte metabolism such as Aldh1a1 and Slc22a17, genes related to signal transduction such as Cxcr4, Spag5 and Stmn3, etc, and genes related to transcriptional control and protein biosynthesis such as Hspa1a, Dnajb1, Thra, Hhex and so on.
Affiliation: School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. .
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18: Title: SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor.
Authors: Poulain, Fabienne E, .
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), Vol. 28 (29): 7387-98, 2008 .
Snippet: In this study, we explored the biological properties and functions of SCLIP, a protein of the stathmin family, in Purkinje cell dendritic differentiation and cerebellum development.
Affiliation: Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 839, UMR7102-Neurobiologie des Processus Adaptatifs, Université Pierre et Marie Curie, Université Paris 06, F-75005 Paris, France. .
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19: Title: The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion.
Authors: Mahapatra, Nitish R, .
Journal: Biochemistry, Vol. 47 (27): 7167-78, 2008 .
Snippet: We then focused on the trans-Golgi protein SCLIP (STMN3) and its stathmin paralog SCG10 (STMN2) for functional study.
Affiliation: Department of Medicine, Center for Human Genetics and Genomics, University of California at San Diego, La Jolla, California 92093-0838, USA. .
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20: Title: Palmitoylation of stathmin family proteins domain A controls Golgi versus mitochondrial subcellular targeting.
Authors: Chauvin, Stéphanie, .
Journal: Biology of the cell / under the auspices of the European Cell Biology Organization (Biol Cell), Vol. 100 (10): 577-89, 2008 .
Snippet: Using palmitoylation-deficient GFP (green fluorescent protein) fusion mutants, we demonstrate that domains A of stathmin proteins have the particular ability to control protein targeting to either Golgi or mitochondria, depending on their palmitoylation.
Affiliation: Inserm, U839, 75005 Paris, France. .
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